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5-CHLORO-1H-INDOLE-2-CARBALDEHYDE

5-CHLORO-1H-INDOLE-2-CARBALDEHYDE Structure
5-CHLORO-1H-INDOLE-2-CARBALDEHYDE structure
CAS No.
53590-49-1
Chemical Name:
5-CHLORO-1H-INDOLE-2-CARBALDEHYDE
Synonyms
5-chloro-indole-2-carbaldehyde;5-CHLORO-1H-INDOLE-2-CARBALDEHYDE;1H-Indole-2-carboxaldehyde, 5-chloro-
CBNumber:
CB5166145
Molecular Formula:
C9H6ClNO
Molecular Weight:
179.6
MDL Number:
MFCD06800428
MOL File:
53590-49-1.mol
MSDS File:
SDS
Last updated:2025-07-24 18:13:51
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5-CHLORO-1H-INDOLE-2-CARBALDEHYDE Properties

Melting point 204-206 °C
Boiling point 373.4±22.0 °C(Predicted)
Density 1.431±0.06 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
pka 14.14±0.30(Predicted)
Appearance Off-white to brown Solid

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H319
Precautionary statements  P305+P351+P338
Hazard Codes  Xi
Risk Statements  36-20/21/22
Safety Statements  26-36/37
HazardClass  IRRITANT
HS Code  29339900

5-CHLORO-1H-INDOLE-2-CARBALDEHYDE price More Price(15)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC C588215 5-Chloro-1H-indole-2-carbaldehyde 53590-49-1 100mg $130 2021-12-16 Buy
TRC C588215 5-Chloro-1H-indole-2-carbaldehyde 53590-49-1 10mg $45 2021-12-16 Buy
Apolloscientific OR930619 5-Chloro-1H-indole-2-carbaldehyde 95% 53590-49-1 250mg $215 2021-12-16 Buy
AK Scientific Z2968 5-Chloroindole-2-carboxaldehyde 53590-49-1 250mg $172 2021-12-16 Buy
Matrix Scientific 016207 5-Chloro-1H-indole-2-carbaldehyde 53590-49-1 500mg $184 2021-12-16 Buy
Product number Packaging Price Buy
C588215 100mg $130 Buy
C588215 10mg $45 Buy
OR930619 250mg $215 Buy
Z2968 250mg $172 Buy
016207 500mg $184 Buy

5-CHLORO-1H-INDOLE-2-CARBALDEHYDE Chemical Properties,Uses,Production

Chemical Properties

Light yellow solid

Synthesis

(5-chloro-1H-indol-2-yl)methanol

53590-47-9

5-CHLORO-1H-INDOLE-2-CARBALDEHYDE

53590-49-1

General procedure for the synthesis of 5-chloro-1H-indole-2-carboxaldehyde from (5-chloro-1H-indol-2-yl)methanol: (5-chloro-1H-indol-2-yl)methanol (1 eq.) was dissolved in tetrahydrofuran (THF, 0.5 M), manganese dioxide (3 eq.) was added, the reaction was stirred for 1.5 hr. at room temperature, and the progress of the reaction was monitored by thin layer chromatography (TLC) until the complete conversion of the feedstock. After completion of the reaction, the mixture was filtered through a diatomaceous earth pad, the filtrate was dried with anhydrous magnesium sulfate and concentrated under reduced pressure to remove the solvent to give the crude 5-chloro-1H-indole-2-carbaldehyde in 82% yield.

References

[1] Synlett, 2007, # 11, p. 1707 - 1710
[2] Chemical Communications, 2013, vol. 49, # 28, p. 2894 - 2896
[3] Patent: US2008/9485, 2008, A1. Location in patent: Page/Page column 41
[4] European Journal of Medicinal Chemistry, 2016, vol. 121, p. 561 - 577
[5] Bioorganic and Medicinal Chemistry, 2017, vol. 25, # 6, p. 1889 - 1900

5-CHLORO-1H-INDOLE-2-CARBALDEHYDE Preparation Products And Raw materials

Raw materials

4-Chlorophenylhydrazine hydrochloride Ethanol Ethyl pyruvate Manganese dioxide Polyphosphoric acid
Tetrahydrofuran Lithium Aluminum Hydride (5-chloro-1H-indol-2-yl)methanol

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Preparation Products

5-CHLORO-1H-INDOLE-2-CARBALDEHYDE Suppliers

Global( 58)Suppliers
Supplier Tel Email Country ProdList Advantage
Changzhou Ansciep Chemical Co., Ltd. 		+86 519 86305871 sales@ansciepchem.com CHINA 4241 58
Dayang Chem (Hangzhou) Co.,Ltd. 		+86-0571-88938639 +8617705817739 info@dycnchem.com China 52846 58
PT CHEM GROUP LIMITED 		+86-85511178; peter68@ptchemgroup.com China 35425 58
GIHI CHEMICALS CO.,LIMITED 		+8618058761490 info@gihichemicals.com China 49983 58
Aladdin Scientific 		tp@aladdinsci.com United States 57505 58
Amadis Chemical Company Limited 		571-89925085 sales@amadischem.com China 131957 58
Gihi Chemicals Co., Limited +86-0571-86217390 +8618058761490 info@gihichem.com China 998 58
J & K SCIENTIFIC LTD. 18210857532 jkinfo@jkchemical.com China 96815 76
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35896 56
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42956 64
Supplier Advantage
Changzhou Ansciep Chemical Co., Ltd. 		58
Dayang Chem (Hangzhou) Co.,Ltd. 		58
PT CHEM GROUP LIMITED 		58
GIHI CHEMICALS CO.,LIMITED 		58
Aladdin Scientific 		58
Amadis Chemical Company Limited 		58
Gihi Chemicals Co., Limited 58
J & K SCIENTIFIC LTD. 76
Wuhan Chemwish Technology Co., Ltd 56
Shanghai Hanhong Scientific Co.,Ltd. 64

5-CHLORO-1H-INDOLE-2-CARBALDEHYDE Spectrum

5-CHLORO-1H-INDOLE-2-CARBALDEHYDE(53590-49-1)1HNMR

53590-49-1(5-CHLORO-1H-INDOLE-2-CARBALDEHYDE)Related Search:

5-Chloroindole-2-carboxylic acid Ethyl 5-chloro-2-indolecarboxylate 6-CHLORO-2,3,4,9-TETRAHYDRO-1H-CARBAZOL-1-ONE 5-CHLORO-N-[(DIMETHYLAMINO)METHYLENE]-3-PHENYL-1H-INDOLE-2-CARBOXAMIDE Ethyl 3-amino-5-chloro-1H-indole-2-carboxylate
5-CHLORO-3-FORMYL-1H-INDOLE-2-CARBOXYLIC ACID ETHYL ESTER ETHYL 5-CHLORO-3-METHYL-1H-INDOLE-2-CARBOXYLATE 6-CHLORO-(PHENYLSULFONYL)-1H-INDOLE-3-CARBOXAMIDE 5-CHLORO-3-PHENYL-1H-INDOLE-2-CARBOXYLIC ACID 5,7-DICHLORO-1H-INDOLE-2-CARBOXYLIC ACID
6-chloro-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-one ETHYL 5-CHLORO-3-PHENYL-1H-INDOLE-2-CARBOXYLATE AKOS JY2083294 3-(2-AMINOETHYL)-5-CHLORO-1H-INDOLE-2-CARBOXYLIC ACID 5-chloro-3-phenylthioindole-2-carboxamide
3-ACETYLAMINO-5-CHLORO-1H-INDOLE-2-CARBOXYLIC ACID 5-CHLORO-1-(4-NITROBENZYL)-3-PHENYL-1H-INDOLE-2-CARBOXAMIDE 5-CHLORO-3-PHENYL-1H-INDOLE-2-CARBOXAMIDE

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5-CHLORO-1H-INDOLE-2-CARBALDEHYDE 5-chloro-indole-2-carbaldehyde 1H-Indole-2-carboxaldehyde, 5-chloro- 53590-49-1