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Liranaftate

The third generation of dithiocarbamate antifungal Toxicity Synthesis method Liranaftate cream Uses
Liranaftate
Liranaftate structure
CAS No.
88678-31-3
Chemical Name:
Liranaftate
Synonyms
LNF;M-732;ZEFNART;LIRANAFATE;LIANAFTATE;LIRANAFTATE;PIRITETRATE;phthalenyl)ester;LIPOPEPTIDEACETATE;Piritetrate, M-732, Zefnart
CBNumber:
CB5168482
Molecular Formula:
C18H20N2O2S
Formula Weight:
328.4286
MOL File:
88678-31-3.mol

Liranaftate Properties

Melting point:
98.5-99.5°C
storage temp. 
-20°C Freezer
Merck 
14,5515

SAFETY

RTECS  FD3890000

Liranaftate price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical L0301 Liranaftate >98.0%(HPLC) 88678-31-3 50mg $212 2018-11-22 Buy
TCI Chemical L0301 Liranaftate >98.0%(HPLC) 88678-31-3 250mg $737 2018-11-22 Buy

Liranaftate Chemical Properties,Uses,Production

The third generation of dithiocarbamate antifungal

Liranaftate is a new king of third-generation dithiocarbamate antifungals , it is a new kind of the third category of chemicals,it belongs to squalene cyclooxygenase inhibitors, by inhibiting the fungal cell membrane squalene epoxidation reaction , it hinders the synthesis of ergosterol which is a constituent of cell membranes ,it plays the role of anti-fungal,its anti-fungal activity is 8 times of tolnaftate, and its dermatophytes effect is better than clotrimazole. It has a strong anti-fungal effect on skin filamentous fungi (Trichophyton,Microsporon, Epidermophyton) , it also shows antifungal activity on other filamentous fungi, dark fungi, dimorphic fungi.It is useful in the treatment of tinea capitis, ringworm, athlete's foot, tinea pedis, onychomycosis, tinea, jock itch, tinea versicolor and vulvovaginal candidiasis.

Toxicity

Reproductive toxicity: in general reproductive toxicity tests, subcutaneous administration to SD rats , the largest non-toxic dose for the parent is 20mg/kg, the largest non-toxic dose for the reproductive process and their pups is 100mg/kg.
Genetic Toxicity: Liranaftate mutagenicity tests are negative.
In toxicity tests during teratogenic sensitively period , subcutaneous administration ,the largest non-toxic dose of maternal is 300mg/kg, the largest non-toxic dose to fetal rats is100mg/kg.
In perinatal toxicity tests, administer subcutaneously, the largest non-toxic dose for the mother and newborn pups is 30mg/kg.
The above information is edited by the chemicalbook of Tian Ye.

Synthesis method

5,6,7,8-tetrahydro-2-naphthol reacts with thiophosgene to give the thio-5,6,7,8-tetrahydro-2-naphthyl chloroformate ester and 2-methoxy-6-methylamine pyridine, then react in isopropanol · water at room temperature for 2 hours to obtain liranaftate ,the overall yield is 70%.

Liranaftate cream

Liranaftate cream is a relatively safe topical antifungal formulation . In mutagenicity studies we found that no matter in chromosome aberration tests, or in the bone marrow micronucleus tests, Liranaftate cream has no effect on inducing cell chromosome aberrations , and it has no effect on bone marrow cell proliferation. It is used for the treatment of ringworm, athlete's foot, ringworm, jock itch, tinea versicolor and vulvovaginal candidiasis. Domestic manufacturers include: Chen Xin Shandong Lukang Pharmaceutical Co., Ltd. (Country medicine accurate words H20052287), Beijing Sihuan Pharmaceutical Technology Co., Ltd. Beijing Shengde Lai Bao Pharmaceutical Co., Ltd., Jiangsu zhongdan Pharmaceutical Co., Ltd.( Country medicine accurate words H20052733 ),Henan Tian Fang Pharmaceutical Co., Ltd. (Country medicine accurate words H20052552), and Nanjing Shenghe Pharmaceutical Co., Ltd. (Country medicine accurate words H20052554), Shideda Pharmaceutical (Beijing) Co., Ltd. (Country medicine accurate words H20052742), Kunshan Reddy pharmaceutical Co., Ltd. (Country medicine accurate words H20052345), Hugang Xinya pharmaceutical (Yangzhou) Co., Ltd. (Country medicine accurate words H20070143), Shandong Weigao pharmaceutical Co., Ltd. (Country medicine accurate words H20070073), Yangtze River pharmaceutical Group Co., Ltd. ( Country medicine accurate words H20080036), Heyuante Fukang pharmaceutical Co., Ltd. (Country medicine accurate words H20080162), Shandong Liangfu pharmaceutical Co., Ltd. (Country medicine accurate words H20080187)

Uses

Broad-spectrum antifungal

Description

Liranaftate was launched in Japan as a new topical antifungal for the treatment of dermatophycoses. This compound belonging to the thiocarbamate class of antifungals can be prepared by condensation of 5,6,7,8-tetrahydro-2-naphthol with the corresponding Npyridylthiocarbamoyl chloride. It is a potent and specific inhibitor of squalene epoxidase and consequently a blocker of ergosterol biosynthesis in fungi, without any detectable effect on mammalian cholesterol biosynthesis in rat liver at therapeutic dose levels. Liranaftate was found to be significantly more active than the other thiocarbamate tolnaftate against several dermatophytes, including Trichophyton mentagrophyfes, and against certain yeasts, such as Crypfococcus neoformans. On the other hand, it was inactive against a variety of Gram-positive and negative bacteria. When applicated as a 1 or 2% cream during clinical trials, it was well tolerated and no systemic absorption was observed.

Chemical Properties

White Crystalline Solid

Originator

Tosoh (Japan)

Uses

A squalene epoxidase inhibitor. Used as an antifungal

brand name

Zefnart

Liranaftate Preparation Products And Raw materials

Raw materials

Preparation Products


Liranaftate Suppliers

Global( 207)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
HubeiwidelychemicaltechnologyCo.,Ltd
18627774460
faith@widelychemical.com CHINA 484 58
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21745 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20672 55
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 24192 60
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 27142 58
Jinan Jianfeng Chemical Co., Ltd
15562555968
info@pharmachemm.com CHINA 294 58
Jinan Shengqi pharmaceutical Co,Ltd
86+15552594168
christine@shengqipharm.com CHINA 555 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 sales@jushengtech.com CHINA 28236 58
Chongqing Chemdad Co.,Ltd
+86-19923101450
sales@chemdad.com CHINA 4001 58
Jinan Jianfeng Chemical Co., Ltd. 0531-88110457 88259573
+86 (531) 8811-3608 info@pharmachemm.com China 155 58

View Lastest Price from Liranaftate manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-08-20 Liranaftate
88678-31-3
US $1.00 / KG 1G 98% 100KG career henan chemical co

88678-31-3(Liranaftate)Related Search:


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  • O-(5,6,7,8-tetrahydronaphthalen-2-yl) N-(6-methoxypyridin-2-yl)-N-methylcarbamothioate
  • carbamothioicacid,(6-methoxy-2-pyridinyl)methyl-,o-(5,6,7,8-tetrahydro-2-na
  • phthalenyl)ester
  • LIRANAFATE
  • LIRANAFTATE
  • M-732
  • (6-METHOXY-2-PYRIDINYL)-METHYLCARBAMOTHIOIC ACID O-(5,6,7,8-TETRAHYDRO-2-NAPHTHALENYL) ESTER
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  • ZEFNART
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  • LIPOPEPTIDEACETATE
  • Carbamothioic acid, (6-methoxy-2-pyridinyl)methyl-
  • O-(5,6,7,8-tetrahydro-2-naphthalenyl)ester
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  • N-(6-Methoxy-2-pyridyl)-N-methylthiocarbamic acid O-(5,6,7,8-tetrahydronaphthalene-2-yl) ester
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  • 88678-31-3
  • 8867-31-3
  • C18H20N2O2S
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