ChemicalBook >> CAS DataBase List >>(S)-(-)-α,α-Diphenyl-2-pyrrolidinemethanol
(S)-(-)-α,α-Diphenyl-2-pyrrolidinemethanol
- CAS No.
- 112068-01-6
- Chemical Name:
- (S)-(-)-α,α-Diphenyl-2-pyrrolidinemethanol
- Synonyms
- (S)-DIPHENYL(PYRROLIDIN-2-YL)METHANOL;(S)-DIPHENYLPROLINOL;SDPP;(S)-(-)-ALPHA,ALPHA-DIPHENYL-2-PYRROLIDINEMETHANOL;ALPHA,ALPHA-DIPHENYL-L-PROLINOL;Diphenyl(2-pyrrolidinyl)methanol;(S)-(-)-2-(DIPHENYLHYDROXYMETHYL)PYRROLIDINE;alpha,alpha-Diphenyl;Nebivolol Impurity 49;Dextrodiphenylprolinol
- CBNumber:
- CB5178203
- Molecular Formula:
- C17H19NO
- Molecular Weight:
- 253.34
- MDL Number:
- MFCD00075506
- MOL File:
- 112068-01-6.mol
- MSDS File:
- SDS
Last updated:2023-11-20 15:05:58
| Melting point | 77-80 °C(lit.) |
|---|---|
| alpha | -59 º (c=3, methanol 25 ºC) |
| Boiling point | 396.54°C (rough estimate) |
| Density | 1.0078 (rough estimate) |
| refractive index | -66.5 ° (C=3, CHCl3) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Soluble in chloroform. |
| form | powder |
| pka | 13.15±0.29(Predicted) |
| color | white to off white ., crystal |
| optical activity | [α]20/D 67°, c = 3 in chloroform |
| Merck | 14,155 |
| BRN | 17103 |
| InChIKey | OGCGXUGBDJGFFY-INIZCTEOSA-N |
| CAS DataBase Reference | 112068-01-6(CAS DataBase Reference) |
| FDA UNII | K3HE3KC32M |
| NIST Chemistry Reference | S-(-)-1,1-diphenylprolinol(112068-01-6) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-37/39-24/25-36 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 10-34 | |||||||||
| TSCA | No | |||||||||
| HS Code | 29339900 | |||||||||
| NFPA 704 |
|
(S)-(-)-α,α-Diphenyl-2-pyrrolidinemethanol price More Price(38)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 368199 | (S)-(?)-α,α-Diphenyl-2-pyrrolidinemethanol 99% | 112068-01-6 | 1g | $15.6 | 2024-03-01 | Buy |
| Sigma-Aldrich | 368199 | (S)-(?)-α,α-Diphenyl-2-pyrrolidinemethanol 99% | 112068-01-6 | 5g | $90.5 | 2024-03-01 | Buy |
| TCI Chemical | D2735 | (S)-(-)-alpha,alpha-Diphenyl-2-pyrrolidinemethanol >98.0%(GC)(T) | 112068-01-6 | 1g | $52 | 2024-03-01 | Buy |
| TCI Chemical | D2735 | (S)-(-)-alpha,alpha-Diphenyl-2-pyrrolidinemethanol >98.0%(GC)(T) | 112068-01-6 | 5g | $248 | 2024-03-01 | Buy |
| Alfa Aesar | L09217 | (S)-(-)-alpha,alpha-Diphenylprolinol 98% | 112068-01-6 | 1g | $82 | 2023-06-20 | Buy |
(S)-(-)-α,α-Diphenyl-2-pyrrolidinemethanol Chemical Properties,Uses,Production
Chemical Properties
white to beige crystals or crystalline powder
Uses
suzuki reaction
Uses
(S)-(-)-α,α-Diphenyl-2-pyrrolidinemethanol is used to prepare the corresponding oxazaborolidines for the borane-mediated asymmetric reduction of ketones.
Preparation
Into a four-necked flask, add tetrahydrofuran, L-proline methyl ester hydrochloride, and phenyl magnesium chloride （dissolved in tetrahydrofuran) solution was added dropwise from a constant pressure dropping funnel, and the addition was completed in about 4 hours, and then stirred at 10-15°C for 3 hours. Add water, adjust the pH to 5-6 with 10% ammonium chloride aqueous solution, extract with dichloromethane, extract the aqueous layer twice with dichloromethane each time, and obtain the organic phase. Wash once with saturated sodium chloride aqueous solution. The organic phase was dried with anhydrous sodium sulfate for 4 hours and filtered. The obtained organic phase was distilled under reduced pressure to distill dichloromethane and tetrahydrofuran to obtain light yellow oily (S)-(-)-α,α-Diphenyl-2-pyrrolidinemethanol, yield 86.6%.
Application
(S)-(+)-α,α-Diphenyl-2-pyrrolidinemethanol (DPPM) may be used in the following processes:
- DPPM reacts with catecholborane to form a spiroborate ester, which can be an efficient catalyst for the synthesis of enantiopure alcohols by borane reduction of acetophenone.
- The catalyst generated in situ by reacting DPPM with borane-diethylaniline, can efficiently catalyze the enantioselective reduction of 2′-fluoroacetophenone.
- Mesoporous SBA-15 silica functionalized with DPPM can catalyze the addition of diethylzinc to benzaldehyde to form (S)-1-phenyl-propanol.
General Description
(S)-(-)-α,α-Diphenyl-2-pyrrolidinemethanol is a bifunctional organocatalyst.
(S)-(-)-α,α-Diphenyl-2-pyrrolidinemethanol Preparation Products And Raw materials
Global( 517)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| China Synchem Technology Co.,Ltd. | +86-0552-4929304 +86-18055277008 | wangxuhui1985@126.com | China | 55 | 55 |
| Springchem New Material Technology Co.,Limited | +86-021-62885108 +8613917661608 | info@spring-chem.com | China | 2068 | 57 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 15928 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21691 | 55 |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9348 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Shanghai Arbor Chemical Co., Ltd. | 021-60451682 | act@arborchemical.com | CHINA | 906 | 58 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 6992 | 58 |
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View Lastest Price from (S)-(-)-α,α-Diphenyl-2-pyrrolidinemethanol manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-09-06 | (S)-(+)-α,α-Diphenyl-2-pyrrolidinemethanol
112068-01-6
|
US $0.00 / KG | 1KG | 99% | 500000kg | Hebei Guanlang Biotechnology Co., Ltd. | |
 |
2023-01-31 | (S)-(-)-Diphenyl-2-Pyrrolidinemethanol
112068-01-6
|
US $100.00 / kg | 25kg | 99.99% | 200ton | Hebei Mojin Biotechnology Co., Ltd | |
 |
2022-09-17 | (S)-(+)-α,α-Diphenyl-2-pyrrolidinemethanol
112068-01-6
|
US $0.00-0.00 / KG | 1KG | 98% | 1ton | Henan Aochuang Chemical Co.,Ltd. |
-
- (S)-(+)-α,α-Diphenyl-2-pyrrolidinemethanol
112068-01-6
- US $0.00 / KG
- 99%
- Hebei Guanlang Biotechnology Co., Ltd.
-
- (S)-(-)-Diphenyl-2-Pyrrolidinemethanol
112068-01-6
- US $100.00 / kg
- 99.99%
- Hebei Mojin Biotechnology Co., Ltd
-
- (S)-(+)-α,α-Diphenyl-2-pyrrolidinemethanol
112068-01-6
- US $0.00-0.00 / KG
- 98%
- Henan Aochuang Chemical Co.,Ltd.
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