METHIOTHEPIN MALEATE
- CAS No.
- 20229-30-5
- Chemical Name:
- METHIOTHEPIN MALEATE
- Synonyms
- RO 8-6837;Metitepine;methiothepin;Methiothepine;METITEPINE MESYLATE;METHIOTHEPIN MALEATE;METHIOTHEPIN MESYLATE;8-Methylthio-10-(4-methylpiperazino)-10,11-dihydrodibenzo[b,f]thiepine;(+-)-8-methylthio-10-(4-methylpiperazino)-10,11-dihydrodibenzo(b,f)thiepin;dibenzo(b,f)thiepin,10,11-dihydro-10-(4-methylpiperazinyl)-8-(methylthio)-(
- CBNumber:
- CB5181681
- Molecular Formula:
- C20H24N2S2
- Molecular Weight:
- 356.55
- MDL Number:
- MFCD00209930
- MOL File:
- 20229-30-5.mol
Melting point | 88-89° |
---|---|
Boiling point | 462.9±45.0 °C(Predicted) |
Density | 1.25±0.1 g/cm3(Predicted) |
storage temp. | Store at RT |
solubility | H2O: 13 mg/mL |
form | solid |
pka | 7.95±0.42(Predicted) |
color | white |
FDA UNII | 55D94103HL |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H319-H315-H335 |
Precautionary statements | P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362 |
WGK Germany | 3 |
METHIOTHEPIN MALEATE Chemical Properties,Uses,Production
Uses
5HT1&2 receptor antagonist
Uses
Methiothepin Maleate exhibits anticonvulsant property and it is able to suppress pentylenetetrazol induced fos expression in zebrafish. In addition, Methiothepin Maleate is a 5-HT antagonist.
Definition
ChEBI: Methiothepin is a dibenzothiepine that is 10,11-dihydrodibenzo[b,f]thiepine bearing additional methylthio and 4-methylpiperazin-1-yl substituents at positions 8 and 10 respectively. Potent 5-HT2 antagonist, also active as 5-HT1 antagonist. Differentiates 5-HT1D sub-types. Also displays affinity for rodent 5-HT5B, 5-HT5A, 5-HT7 and 5-HT6 receptors (pK1 values are 6.6, 7.0, 8.4 and 8.7 respectively). It has a role as an antipsychotic agent, a dopaminergic antagonist, a serotonergic antagonist and a geroprotector. It is a N-alkylpiperazine, a dibenzothiepine, an aryl sulfide and a tertiary amino compound. It is a conjugate base of a methiothepin(2+).
Biological Activity
Potent 5-HT 2 antagonist, also active as 5-HT 1 antagonist. Differentiates 5-HT 1D sub-types. Also displays affinity for rodent 5-HT 5B , 5-HT 5A , 5-HT 7 and 5-HT 6 receptors (pK 1 values are 6.6, 7.0, 8.4 and 8.7 respectively).
METHIOTHEPIN MALEATE Preparation Products And Raw materials
Raw materials
Preparation Products
METHIOTHEPIN MALEATE Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
Shanghai TaoSu Biochemical Technology Co., Ltd. | 021-33632979 | info@tsbiochem.com | China | 8072 | 58 |
Shanghai Synchem Pharma Co., ltd | 21-619849051-1 18521059765 | synchempharma@aliyun.com | China | 6463 | 55 |
EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8449 | 60 |
TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 18779 | 58 |