Lomerizine hydrochloride
- CAS No.
- 101477-54-7
- Chemical Name:
- Lomerizine hydrochloride
- Synonyms
- KB 2796;TERRANAS;Lomeizine HCL;LOMERIZINE HCL;Lomerizine2HCl;LOMERIZINE DIHCL;KB-2796, Terranas;LOMERIZINEHYDROCHLORTDE;KB-2796 dihydrochloride;LOMERIZINE HYDROCHLORIDE
- CBNumber:
- CB5186585
- Molecular Formula:
- C27H32Cl2F2N2O3
- Molecular Weight:
- 541.46
- MDL Number:
- MFCD01703867
- MOL File:
- 101477-54-7.mol
| Melting point | 214-218°C dec. |
|---|---|
| storage temp. | Inert atmosphere,2-8°C |
| solubility | DMSO: ≥30mg/mL |
| form | powder |
| color | white to tan |
| Merck | 14,5563 |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month. |
| CAS DataBase Reference | 101477-54-7(CAS DataBase Reference) |
| FDA UNII | 3W473D5LIY |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H410 | |||||||||
| Precautionary statements | P264-P270-P273-P301+P312-P391-P501 | |||||||||
| Hazard Codes | Xn,N | |||||||||
| Risk Statements | 22-50 | |||||||||
| Safety Statements | 61 | |||||||||
| RIDADR | UN 3077 9 / PGIII | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | TK9189000 | |||||||||
| HS Code | 29335990 | |||||||||
| Toxicity | LD50 orally in mice: 300 mg/kg (Ohtaka) | |||||||||
| NFPA 704 |
|
Lomerizine hydrochloride price More Price(24)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | L6295 | Lomerizine dihydrochloride ≥98% (HPLC), powder | 101477-54-7 | 10mg | $105 | 2024-03-01 | Buy |
| Sigma-Aldrich | L6295 | Lomerizine dihydrochloride ≥98% (HPLC), powder | 101477-54-7 | 50mg | $416 | 2024-03-01 | Buy |
| TCI Chemical | L0245 | Lomerizine Dihydrochloride >98.0%(HPLC)(T) | 101477-54-7 | 1g | $308 | 2024-03-01 | Buy |
| TCI Chemical | L0245 | Lomerizine Dihydrochloride >98.0%(HPLC)(T) | 101477-54-7 | 200mg | $90 | 2024-03-01 | Buy |
| Cayman Chemical | 28374 | Lomerizine (hydrochloride) | 101477-54-7 | 250mg | $68 | 2024-03-01 | Buy |
Lomerizine hydrochloride Chemical Properties,Uses,Production
Description
Lomerizine hydrochloride was introduced as Teranas and Migsis in Japan for the treatment of migraine. It is the first in its class of dual sodium and calcium channel blockers to be marketed for this indication. It can be synthetically obtained by reductive amination of 2,3,4-trimethoxybenzaldehyde with the appropiate benzhydryl piperazine. In dogs, Lomerizine exerts a potent, selective and long-lasting vasodilation of cerebral arteries related to a combination of mechanisms, especially a functional block of L-type voltagesensitive calcium channels (L-VSCCs). Lomerizine increases cerebral blood flow compared to peripheral blood flow with only weak effects on systemic arterial blood pressure. Other mechanisms involved could be blockade of other VSCC and sodium channels, 5-HT2 and alpha-1 receptors. As a reducing agent of cortical spreading depression and neurogenic inflammation, Lomerizine was shown to be useful in migraine. In an open clinical study, it demonstrated efficacy in the treatment of cluster headache. Moreover, it may have utility in other neurological diseases such as cerebrovascular ischemia or cerebral infarction.
Chemical Properties
Colourless Crystalline Solid
Originator
Akzo Nobel (Netherlands)
Uses
A diphenylpiperazine calcium channel blocker. A selective cerebral vasodilator. Antimigraine.
brand name
Teranas;Migsis
References
1) Ishii?et al. (2009), Inhibitory effect of lomerizine, a prophylactic drug for migraines, on serotonin-induced contraction of the basilar artery; ?J. Pharmacol. Sci. 111 221 2)?Hara et al. (2004), Clinical potential of lomerizine, a Ca2+ channel blocker as an anti-glaucoma drug: effects on ocular circulation and retinal neuronal damage; Cardiovasc.Drug Rev. 22 199 3)?Ishii et al. (2011), Neuroprotection by lomerizine, a prophylactic drug for migraine, against hydrogen peroxide-induced hippocampal neurotoxicity; Mol. Cell Biochem. 358 1 4) Savigni?et al. (2013), Three Ca2+ channel inhibitors in combination limit chronic secondary degeneration following neurotrauma; ?Neuropharmacology 75 380 5) Tran?et al. (2014), The voltage-gated calcium channel blocker lomerizine is neuroprotective in motor neurons expressing mutant SOD, but not TDP-43; ?J. Neurochem. 130 455 6) O’Hare?et al. (2016), Specific combinations of ion channel inhibitors reduce excessive Ca2+ influx as a consequence of oxidative stress and increase neuronal and glial cell viability in vitro; ?Neuroscience 339 450
Lomerizine hydrochloride Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Yingrui Biopharma Co., Ltd. | +86-21-33585366 - 03@ | sales03@shyrchem.com | CHINA | 738 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-592-6051114 +8618959220845 | sales@amoychem.com | China | 6387 | 58 |
| Shanghai Yingrui Biopharma Co.,Ltd | 21-33585366 | export01@shyrchem.com | CHINA | 1320 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| Nanjing Shizhou Biotechnology Co., Ltd | +86-15850508050 +86-15850508050 | sean.lv@synzest.com | China | 323 | 58 |
| SIMAGCHEM CORP | +86-13806087780 | sale@simagchem.com | China | 17367 | 58 |
| SINOPRO.CO.LTD | 0082-42-721-7177 | michael@sinopro.co.kr | South Korea | 298 | 58 |
View Lastest Price from Lomerizine hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-02-12 | Lomerizine hydrochloride
101477-54-7
|
US $7.00 / KG | 1KG | 99% | 100KG | Career Henan Chemical Co |
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- Lomerizine hydrochloride
101477-54-7
- US $7.00 / KG
- 99%
- Career Henan Chemical Co
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