4-Amino-6-chloro-1--D-ribofuranosylimidazo[4,5-c]pyridine
![4-Amino-6-chloro-1--D-ribofuranosylimidazo[4,5-c]pyridine Structure](CAS2/GIF/40656-71-1.gif)
- CAS No.
- 40656-71-1
- Chemical Name:
- 4-Amino-6-chloro-1--D-ribofuranosylimidazo[4,5-c]pyridine
- Synonyms
- NSC 158900;2-chloro-3-Deazaadenosine;6-Amino-2-chloro-9-(b-D-ribofuranosyl)purine;4-Amino-6-chloro-1--D-ribofuranosylimidazo[4,5-c]pyridine;4-Amino-6-chloro-1-β-D-ribofuranosylimidazo[4,5-c]pyridine;6-Chloro-1-β-D-ribofuranosyl-1H-iMidazo[4,5-c]pyridin-4-aMine;1H-Imidazo[4,5-c]pyridin-4-amine, 6-chloro-1-β-D-ribofuranosyl-;(2R,4R,5R)-2-(4-amino-6-chloroimidazo[4,5-c]pyridin-1-yl)-5-(hydroxymethyl)oxolane-3,4-diol;(2R,3R,4S,5R)-2-(4-amino-6-chloro-1H-imidazo[4,5-c]pyridin-1-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
- CBNumber:
- CB51872799
- Molecular Formula:
- C11H13ClN4O4
- Molecular Weight:
- 300.7
- MDL Number:
- MFCD00005734
- MOL File:
- 40656-71-1.mol
4-Amino-6-chloro-1--D-ribofuranosylimidazo[4,5-c]pyridine price More Price(16)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 9000787 | 2-chloro-3-Deazaadenosine ≥98% | 40656-71-1 | 1mg | $77 | 2024-03-01 | Buy |
| Cayman Chemical | 9000787 | 2-chloro-3-Deazaadenosine ≥98% | 40656-71-1 | 5mg | $340 | 2024-03-01 | Buy |
| Cayman Chemical | 9000787 | 2-chloro-3-Deazaadenosine ≥98% | 40656-71-1 | 10mg | $602 | 2024-03-01 | Buy |
| TRC | A603514 | 4-Amino-6-chloro-1-β-D-ribofuranosylimidazo[4,5-c]pyridine | 40656-71-1 | 1mg | $50 | 2021-12-16 | Buy |
| Biosynth Carbosynth | NC09808 | 2-Chloro-3-deazaadenosine | 40656-71-1 | 1mg | $75 | 2021-12-16 | Buy |
4-Amino-6-chloro-1--D-ribofuranosylimidazo[4,5-c]pyridine Chemical Properties,Uses,Production
Chemical Properties
Off-White Solid
Uses
Adenosine analog
Biological Activity
2-chloro-3-deazaadenosine, a stable analog of adenosine, is an agonist for adenosine receptors [1].adenosine receptors are members of g-protein-coupled receptors (gpcrs). extracellular adenosine acts as a local modulator with a generally cytoprotective function in the body. extracellular adenosine has been implicated in increasing the ratio of oxygen supply to demand, protecting against ischaemic damage by cell conditioning, triggering anti-inflammatory responses and the promotion of angiogenesis [2].
in vitro
the ki values of 2-chloro-3-deazaadenosine for a1, a2a, a2b, and a3 receptors were 0.3, 0.08, 25.5, and 1.9 μm, respectively [1]. 2-chloroadenosine (25 μm) increased activity of platelet adenylate cyclase to about 150–160% of the control value. higher concentrations of 2-chloroadenosine showed less effect above 100 μm [3].
in vivo
in the rat with delayed ischaemic damage, iterative focal injections of 2-chloroadenosine protected against selective hippocampal ca1 loss [4].
References
[1] linden j, thai t, figler h, et al. characterization of human a2b adenosine receptors: radioligand binding, western blotting, and coupling to gqin human embryonic kidney 293 cells and hmc-1 mast cells[j]. molecular pharmacology, 1999, 56(4): 705-713.
[2] jacobson k a, gao z g. adenosine receptors as therapeutic targets[j]. nature reviews drug discovery, 2006, 5(3): 247-264.
[3] haslam r j, lynham j a. activation and inhibition of blood platelet adenylate cyclase by adenosine or by 2-chloroadenosine[j]. life sciences, 1972, 11(23): 1143-1154.
[4] evans m c, swan j h, meldrum b s. an adenosine analogue, 2-chloroadenosine, protects against long term development of ischaemic cell loss in the rat hippocampus[j]. neuroscience letters, 1987, 83(3): 287-292.
4-Amino-6-chloro-1--D-ribofuranosylimidazo[4,5-c]pyridine Preparation Products And Raw materials
Raw materials
Preparation Products
4-Amino-6-chloro-1--D-ribofuranosylimidazo[4,5-c]pyridine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| NewCan Biotech Limited | +86-0571-86912261 +8613735419629 | sales@newcanbio.com | China | 10027 | 58 |
| Shanxi Tihondan Pharmaceutical Technology Co., Ltd | +8618235132063 | sales@tihondan.com | China | 3716 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32344 | 50 |
| Shanghai TaoSu Biochemical Technology Co., Ltd. | 021-33632979 | info@tsbiochem.com | China | 8073 | 58 |
| BOC Sciences | 16314854226 | info@bocsci.com | United States | 9926 | 65 |
| Beijing Minruida Technology Co., Ltd. | 010-82387566 18001021521; | sales@mreda.com.cn | China | 21450 | 58 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 13028896684 | sales@rrkchem.com | China | 55717 | 58 |
View Lastest Price from 4-Amino-6-chloro-1--D-ribofuranosylimidazo[4,5-c]pyridine manufacturers
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![(2R,4R,5R)-2-(4-amino-6-chloroimidazo[4,5-c]pyridin-1-yl)-5-(hydroxymethyl)oxolane-3,4-diol pictures](https://img.chemicalbook.com/ProductImageEN/2020-1/Small/1a5f2de5-b013-4d9e-bdce-20141dcab3e2.jpg) |
2020-01-10 | (2R,4R,5R)-2-(4-amino-6-chloroimidazo[4,5-c]pyridin-1-yl)-5-(hydroxymethyl)oxolane-3,4-diol
40656-71-1
|
US $0.01 / KG | 1KG | 98%; 99% | 500g;1kg； 25kg | Career Henan Chemical Co |
-
- (2R,4R,5R)-2-(4-amino-6-chloroimidazo[4,5-c]pyridin-1-yl)-5-(hydroxymethyl)oxolane-3,4-diol
40656-71-1
- US $0.01 / KG
- 98%; 99%
- Career Henan Chemical Co