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Ethyl (R)-(-)-4-cyano-3-hydroxybutyate

CAS No.
141942-85-0
Chemical Name:
Ethyl (R)-(-)-4-cyano-3-hydroxybutyate
Synonyms
ATS-5;RETINCIC ACID;Ethyl (R)-(−Ethyl (R)-(-)-4-cyan;(R)-Ethyl 4-cyano-3-;Ats-5(For Atorvastatin);Atorvastatin Impurity 127;)-4-cyano-3-hydroxybutyrate;(R)-4-cyano-3-hydroxybutyric;(R)-4-Cyano-3-hydroxy butanoate
CBNumber:
CB5188978
Molecular Formula:
C7H11NO3
Formula Weight:
157.17
MOL File:
141942-85-0.mol
MSDS File:
SDS

Ethyl (R)-(-)-4-cyano-3-hydroxybutyate Properties

alpha
-5 º (neat)
Boiling point
270 °C(lit.)
Density
1.114 g/mL at 25 °C(lit.)
refractive index
n20/D 1.448(lit.)
Flash point
>230 °F
storage temp.
2-8°C
pka
13.03±0.20(Predicted)
form
Liquid
Specific Gravity
1.114
color
Colorless to yellow
optical activity
[α]25/D 5°, neat
BRN
5328715
InChIKey
LOQFROBMBSKWQY-ZCFIWIBFSA-N
CAS DataBase Reference
141942-85-0(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302+H312+H332-H315-H319-H335
Precautionary statements  P261-P305+P351+P338-P264-P270-P271-P280-P301+P312+P330-P302+P352+P312+P362+P364-P304+P340+P312-P305+P351+P338+P337+P313-P501
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
WGK Germany  1
HS Code  29269090

Ethyl (R)-(-)-4-cyano-3-hydroxybutyate price More Price(28)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 479772 Ethyl (R)-(?)-4-cyano-3-hydroxybutyrate 95% 141942-85-0 5g $43.6 2022-05-15 Buy
TCI Chemical C1474 Ethyl (R)-(-)-4-Cyano-3-hydroxybutyrate >97.0%(GC) 141942-85-0 1g $16 2022-04-27 Buy
TCI Chemical C1474 Ethyl (R)-(-)-4-Cyano-3-hydroxybutyrate >97.0%(GC) 141942-85-0 5g $44 2022-04-27 Buy
Alfa Aesar L19771 Ethyl (R)-(-)-4-cyano-3-hydroxybutyrate, 98% 141942-85-0 5g $42.6 2021-12-16 Buy
Alfa Aesar L19771 Ethyl (R)-(-)-4-cyano-3-hydroxybutyrate, 98% 141942-85-0 25g $136 2021-12-16 Buy
Product number Packaging Price Buy
479772 5g $43.6 Buy
C1474 1g $16 Buy
C1474 5g $44 Buy
L19771 5g $42.6 Buy
L19771 25g $136 Buy

Ethyl (R)-(-)-4-cyano-3-hydroxybutyate Chemical Properties,Uses,Production

Chemical Properties

yellow liquid

Uses

Atorvastatin Intermediate

Uses

(3R)-4-Cyano-3-hydroxybutanoic Acid Ethyl Ester is used in a biocatalytic process for the synthesis of an atorvastatin intermediate and degredation products/impurities.

Uses

analgesic, antipyretic, and anti-inflammatory

Application

Hydroxyglutaryl coenzyme A (HMG-CoA) reductase inhibitors are a new class of lipid-lowering drugs, and they have a market share of more than 10 billion US dollars in the current pharmaceutical field. They can selectively inhibit the rate-limiting enzyme HMG-CoA reductase in cholesterol synthesis in the liver, reduce liver lipoprotein production, and increase the expression of low-density lipoprotein (LDL) cholesterol receptors, thereby reducing plasma cholesterol levels. They can also significantly reduce very low-density lipoprotein (VLDL) and triglycerides, and increase anti-atherosclerotic high-density protein (HDL), preventing atherosclerosis and coronary heart disease.
Ethyl (R)-(-)-4-cyano-3-hydroxybutyate is an important intermediate for the synthesis of HMG-CoA reductase inhibitors. If it is used as a raw material, synthetic atorvastatin is mainly used for the treatment of hypercholesterolemia and mixed hyperlipidemia, coronary heart disease and stroke.

64-17-5
287955-93-5
141942-85-0
Synthesis of Ethyl (R)-(-)-4-cyano-3-hydroxybutyate from Ethanol and Butanoic acid, 4-cyano-3-hydroxy-, (3R)-

Ethyl (R)-(-)-4-cyano-3-hydroxybutyate Preparation Products And Raw materials

Global( 307)Suppliers
Supplier Tel Email Country ProdList Advantage
HENAN BON INDUSTRIAL CO.,LTD
0371-55170695 info@hnbon.com CHINA 26742 58
Henan DaKen Chemical CO.,LTD.
371-66670886 info@dakenchem.com China 15400 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693 info@tianfuchem.com China 22022 55
Hangzhou FandaChem Co.,Ltd.
+8615858145714 fandachem@gmail.com China 9515 55
Hubei XinRunde Chemical Co., Ltd.
+8615102730682 bruce@xrdchem.cn CHINA 567 55
Zjartschem
+86-571-8723 8903 jocelynpan@zjarts.com jocelynpan@zjarts.com CHINA 997 58
Hebei Minshang Biotechnology Co.,Ltd
+8613582176207 cathy@hbminshang.cn China 302 58
career henan chemical co
+86-0371-86658258 sales@coreychem.com China 29960 58
NINGBO INNO PHARMCHEM CO., LTD.
13867897135 sales@nbinno.com CHINA 925 58
Accela ChemBio Inc.
(+1)-858-699-3322 info@accelachem.com United States 19969 58

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View Lastest Price from Ethyl (R)-(-)-4-cyano-3-hydroxybutyate manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-12-27 Ethyl (3R)-4-cyano-3-hydroxybutanoate
141942-85-0
US $1.00 / KG 1KG 99% 500ton/month Hebei Minshang Biotechnology Co.,Ltd
2021-12-01 (R)-(-)-4-CYANO-3-HYDROXYBUTYRIC ACID ETHYL ESTER
141942-85-0
US $10.50 / KG 1KG 98% 10 ton Hebei Crovell Biotech Co Ltd
2021-07-02 Ethyl (R)-(-)-4-cyano-3-hydroxybutyrate[141942-85-0]
141942-85-0
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
(R)-(-)-4-CYANO-3-HYDROXYBUTYRIC ACID ETHYL ESTER (R)-4-CYANO-3-HYDROXYBUTYRIC ACID ETHYL ESTER (R)-(-)-ETHYL 4-CYANO-3-HYDROXYBUTYRATE (R)-ETHYL 4-CYANO-3-HYDROXYBUTYRATE (S)-4-CYANO-3-HYDROXYBUTANOATE ETHYL ETHYL (3R)-4-CYANO-3-HYDROXY-BUTANOATE ETHYL (S)-4-CYANO-3-HYDROXYBUTANOATE ETHYL (R)-4-CYANO-3-HYDROXYBUTANOATE ETHYL-(R)-(+)-4-CYANO-3-HYDROXYBUTANOATE Ethyl (R)-(-)-4-cyano-3-hydroxybutyate ETHYL (R)-(-)-4-CYANO-3-HYDROXYBUTYRATE ETHYL (R)-4-CYANO-3-HYDROXYBUTYRATE BUTANOIC ACID, 4-CYANO-3-HYDROXY-, ETHYL ESTER, (R) BUTANOIC ACID 4-CYANO-3-HYDROXY-ETHYL ESTER, (S) thyl (R)-(-)-4-Cyano-3-Hydroxy Butyate (3R)-4-cyano-3-hydroxybutyric acid ethyl ester FEthyl (R)-(-)-4-cyano-3-hydroxybutyrate Atorvastatin interMediates Ats-5 (R)-4-cyano-3-hydrobutyric acid ethyl ester Butanoic acid, 4-cyano-3-hydroxy-, ethyl ester, (3R)- (3R)-4-Cyano-3-hydroxybutanoic Acid Ethyl Ester Ethyl (R)-(-)-4-cyano-3-hydroxybutyrate[141942-85-0] ethyle(R)-4-cyano-3-hydroxybutanoate ATS-5 (R)-4-Cyano-3-hydroxy butanoate (R)-4-cyano-3-hydroxybutyric R(-)-4-cyano-3-hydroxybutyrtc ethyl ester ATS-5:(R)ETHYL-4-CYANO-3-HYCLROXY BUTANCATE R(-)4-CYANO-3-HYDROXYBUTYRIC ETHYL ESTER R(-)-4-CYANO-3-HYDROXYBUTYRTC ETHYL ESTER /ATS-5 R(-)-4-Cyano-3-hydroxubutyricethylester (R)-4-Cyano-3-hydroxybuttersureethylester (R)-4-cyano-3-hydrobutyric acid ethyl ester (R)-4-CYANO-3-HYDROXYBUTANOATE ETHYL RETINCIC ACID [R]-[-]-Ethyl-cyano-3-hydroxybutyrate (R)-(-)-4-Cyano-3-hydroxybutyratic acid, ethyl ester Ethyl (R)-4-cyano-3-hydroxybutanoate,99% Ethyl (R)-4-cyano-3-hydroxybutanoate,95% Atorvastatincalcium(R)-4-cyano-3-hydrobutyric Acid Ethyl Ester Ethyl (R)-(-)-4-cyan 4-Cyano-3-hydroxy-butyric acid ethyl ester )-4-cyano-3-hydroxybutyrate Ethyl (R)-(− Ethyl-(R)-4-(-)-cyano-3-hydroxybutyrate(C-1) (R)-Ethyl 4-cyano-3- Ats-5(For Atorvastatin) Ethyl (R)-(-)-4-Cyano-3-hydroxybutyrate > (R)-(-)-4-Cyano-3-hydroxybutyrate Atorvastatin Impurity 127 Ethyl (R)-(-)-4-cyano-3-hydroxybutyate fandachem (3R)-4-Cyano-3-hydroxybutanoic Acid Ethyl (R)-(-)-4-CYANO-3-HYDROXYBUTYATE (3R)-4-Cyano-3-hydroxybutyric Acid Ethyl EsterQ: What is (3R)-4-Cyano-3-hydroxybutyric Acid Ethyl Ester Q: What is the CAS Number of (3R)-4-Cyano-3-hydroxybutyric Acid Ethyl Ester Q: What is the storage condition of (3R)-4-Cyano-3-hydroxybutyric Acid Ethyl Ester 141942-85-0 41942-85-0 NCCH2CHOHCH2CO2C2H5 Organic Building Blocks Esters