ChemicalBook >> CAS DataBase List >>Ethyl (R)-(-)-4-cyano-3-hydroxybutyate
Ethyl (R)-(-)-4-cyano-3-hydroxybutyate
- CAS No.
- 141942-85-0
- Chemical Name:
- Ethyl (R)-(-)-4-cyano-3-hydroxybutyate
- Synonyms
- ATS-5;RETINCIC ACID;Ethyl (R)-(−Ethyl (R)-(-)-4-cyan;(R)-Ethyl 4-cyano-3-;Ats-5(For Atorvastatin);Atorvastatin Impurity 127;)-4-cyano-3-hydroxybutyrate;(R)-4-cyano-3-hydroxybutyric;(R)-4-Cyano-3-hydroxy butanoate
- CBNumber:
- CB5188978
- Molecular Formula:
- C7H11NO3
- Formula Weight:
- 157.17
- MOL File:
- 141942-85-0.mol
- MSDS File:
- SDS
- alpha
- -5 º (neat)
- Boiling point
- 270 °C(lit.)
- Density
- 1.114 g/mL at 25 °C(lit.)
- refractive index
- n
20/D 1.448(lit.)
- Flash point
- >230 °F
- storage temp.
- 2-8°C
- pka
- 13.03±0.20(Predicted)
- form
- Liquid
- Specific Gravity
- 1.114
- color
- Colorless to yellow
- optical activity
- [α]25/D 5°, neat
- BRN
- 5328715
- InChIKey
- LOQFROBMBSKWQY-ZCFIWIBFSA-N
- CAS DataBase Reference
- 141942-85-0(CAS DataBase Reference)
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302+H312+H332-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338-P264-P270-P271-P280-P301+P312+P330-P302+P352+P312+P362+P364-P304+P340+P312-P305+P351+P338+P337+P313-P501 |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| WGK Germany | 1 |
| HS Code | 29269090 |
Ethyl (R)-(-)-4-cyano-3-hydroxybutyate price More Price(28)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 479772 | Ethyl (R)-(?)-4-cyano-3-hydroxybutyrate 95% | 141942-85-0 | 5g | $43.6 | 2022-05-15 | Buy |
| TCI Chemical | C1474 | Ethyl (R)-(-)-4-Cyano-3-hydroxybutyrate >97.0%(GC) | 141942-85-0 | 1g | $16 | 2022-04-27 | Buy |
| TCI Chemical | C1474 | Ethyl (R)-(-)-4-Cyano-3-hydroxybutyrate >97.0%(GC) | 141942-85-0 | 5g | $44 | 2022-04-27 | Buy |
| Alfa Aesar | L19771 | Ethyl (R)-(-)-4-cyano-3-hydroxybutyrate, 98% | 141942-85-0 | 5g | $42.6 | 2021-12-16 | Buy |
| Alfa Aesar | L19771 | Ethyl (R)-(-)-4-cyano-3-hydroxybutyrate, 98% | 141942-85-0 | 25g | $136 | 2021-12-16 | Buy |
Ethyl (R)-(-)-4-cyano-3-hydroxybutyate Chemical Properties,Uses,Production
Chemical Properties
yellow liquid
Uses
Atorvastatin Intermediate
Uses
(3R)-4-Cyano-3-hydroxybutanoic Acid Ethyl Ester is used in a biocatalytic process for the synthesis of an atorvastatin intermediate and degredation products/impurities.
Uses
analgesic, antipyretic, and anti-inflammatory
Application
Hydroxyglutaryl coenzyme A (HMG-CoA) reductase inhibitors are a new class of lipid-lowering drugs, and they have a market share of more than 10 billion US dollars in the current pharmaceutical field. They can selectively inhibit the rate-limiting enzyme HMG-CoA reductase in cholesterol synthesis in the liver, reduce liver lipoprotein production, and increase the expression of low-density lipoprotein (LDL) cholesterol receptors, thereby reducing plasma cholesterol levels. They can also significantly reduce very low-density lipoprotein (VLDL) and triglycerides, and increase anti-atherosclerotic high-density protein (HDL), preventing atherosclerosis and coronary heart disease.
Ethyl (R)-(-)-4-cyano-3-hydroxybutyate is an important intermediate for the synthesis of HMG-CoA reductase inhibitors. If it is used as a raw material, synthetic atorvastatin is mainly used for the treatment of hypercholesterolemia and mixed hyperlipidemia, coronary heart disease and stroke.
Synthesis of Ethyl (R)-(-)-4-cyano-3-hydroxybutyate from Ethanol and Butanoic acid, 4-cyano-3-hydroxy-, (3R)-
Ethyl (R)-(-)-4-cyano-3-hydroxybutyate Preparation Products And Raw materials
Global( 307)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| HENAN BON INDUSTRIAL CO.,LTD | 0371-55170695 | info@hnbon.com | CHINA | 26742 | 58 |
| Henan DaKen Chemical CO.,LTD. | 371-66670886 | info@dakenchem.com | China | 15400 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | 0371-55170693 | info@tianfuchem.com | China | 22022 | 55 |
| Hangzhou FandaChem Co.,Ltd. | +8615858145714 | fandachem@gmail.com | China | 9515 | 55 |
| Hubei XinRunde Chemical Co., Ltd. | +8615102730682 | bruce@xrdchem.cn | CHINA | 567 | 55 |
| Zjartschem | +86-571-8723 8903 jocelynpan@zjarts.com | jocelynpan@zjarts.com | CHINA | 997 | 58 |
| Hebei Minshang Biotechnology Co.,Ltd | +8613582176207 | cathy@hbminshang.cn | China | 302 | 58 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29960 | 58 |
| NINGBO INNO PHARMCHEM CO., LTD. | 13867897135 | sales@nbinno.com | CHINA | 925 | 58 |
| Accela ChemBio Inc. | (+1)-858-699-3322 | info@accelachem.com | United States | 19969 | 58 |
Related articles
- What is Ethyl (R)-(-)-4-cyano-3-hydroxybutyate?
- Hydroxyglutaryl coenzyme A (HMG-CoA) reductase inhibitors are a new class of lipid-lowering drugs, and they have a market shar....
- Feb 25，2020
View Lastest Price from Ethyl (R)-(-)-4-cyano-3-hydroxybutyate manufacturers
| Image | Release date | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-12-27 | Ethyl (3R)-4-cyano-3-hydroxybutanoate
141942-85-0
|
US $1.00 / KG | 1KG | 99% | 500ton/month | Hebei Minshang Biotechnology Co.,Ltd | |
 |
2021-12-01 | (R)-(-)-4-CYANO-3-HYDROXYBUTYRIC ACID ETHYL ESTER
141942-85-0
|
US $10.50 / KG | 1KG | 98% | 10 ton | Hebei Crovell Biotech Co Ltd | |
 |
2021-07-02 | Ethyl (R)-(-)-4-cyano-3-hydroxybutyrate[141942-85-0]
141942-85-0
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
-
- Ethyl (3R)-4-cyano-3-hydroxybutanoate
141942-85-0
- US $1.00 / KG
- 99%
- Hebei Minshang Biotechnology Co.,Ltd
-
- (R)-(-)-4-CYANO-3-HYDROXYBUTYRIC ACID ETHYL ESTER
141942-85-0
- US $10.50 / KG
- 98%
- Hebei Crovell Biotech Co Ltd
-
- Ethyl (R)-(-)-4-cyano-3-hydroxybutyrate[141942-85-0]
141942-85-0
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
141942-85-0(Ethyl (R)-(-)-4-cyano-3-hydroxybutyate)Related Search:
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(R)-(-)-4-CYANO-3-HYDROXYBUTYRIC ACID ETHYL ESTER
(R)-4-CYANO-3-HYDROXYBUTYRIC ACID ETHYL ESTER
(R)-(-)-ETHYL 4-CYANO-3-HYDROXYBUTYRATE
(R)-ETHYL 4-CYANO-3-HYDROXYBUTYRATE
(S)-4-CYANO-3-HYDROXYBUTANOATE ETHYL
ETHYL (3R)-4-CYANO-3-HYDROXY-BUTANOATE
ETHYL (S)-4-CYANO-3-HYDROXYBUTANOATE
ETHYL (R)-4-CYANO-3-HYDROXYBUTANOATE
ETHYL-(R)-(+)-4-CYANO-3-HYDROXYBUTANOATE
Ethyl (R)-(-)-4-cyano-3-hydroxybutyate
ETHYL (R)-(-)-4-CYANO-3-HYDROXYBUTYRATE
ETHYL (R)-4-CYANO-3-HYDROXYBUTYRATE
BUTANOIC ACID, 4-CYANO-3-HYDROXY-, ETHYL ESTER, (R)
BUTANOIC ACID 4-CYANO-3-HYDROXY-ETHYL ESTER, (S)
thyl (R)-(-)-4-Cyano-3-Hydroxy Butyate
(3R)-4-cyano-3-hydroxybutyric acid ethyl ester
FEthyl (R)-(-)-4-cyano-3-hydroxybutyrate
Atorvastatin interMediates Ats-5
(R)-4-cyano-3-hydrobutyric acid ethyl ester
Butanoic acid, 4-cyano-3-hydroxy-, ethyl ester, (3R)-
(3R)-4-Cyano-3-hydroxybutanoic Acid Ethyl Ester
Ethyl (R)-(-)-4-cyano-3-hydroxybutyrate[141942-85-0]
ethyle(R)-4-cyano-3-hydroxybutanoate
ATS-5
(R)-4-Cyano-3-hydroxy butanoate
(R)-4-cyano-3-hydroxybutyric
R(-)-4-cyano-3-hydroxybutyrtc ethyl ester
ATS-5:(R)ETHYL-4-CYANO-3-HYCLROXY BUTANCATE
R(-)4-CYANO-3-HYDROXYBUTYRIC ETHYL ESTER
R(-)-4-CYANO-3-HYDROXYBUTYRTC ETHYL ESTER /ATS-5
R(-)-4-Cyano-3-hydroxubutyricethylester
(R)-4-Cyano-3-hydroxybuttersureethylester
(R)-4-cyano-3-hydrobutyric acid ethyl ester
(R)-4-CYANO-3-HYDROXYBUTANOATE ETHYL
RETINCIC ACID
[R]-[-]-Ethyl-cyano-3-hydroxybutyrate
(R)-(-)-4-Cyano-3-hydroxybutyratic acid, ethyl ester
Ethyl (R)-4-cyano-3-hydroxybutanoate,99%
Ethyl (R)-4-cyano-3-hydroxybutanoate,95%
Atorvastatincalcium(R)-4-cyano-3-hydrobutyric Acid Ethyl Ester
Ethyl (R)-(-)-4-cyan
4-Cyano-3-hydroxy-butyric acid ethyl ester
)-4-cyano-3-hydroxybutyrate
Ethyl (R)-(−
Ethyl-(R)-4-(-)-cyano-3-hydroxybutyrate(C-1)
(R)-Ethyl 4-cyano-3-
Ats-5(For Atorvastatin)
Ethyl (R)-(-)-4-Cyano-3-hydroxybutyrate >
(R)-(-)-4-Cyano-3-hydroxybutyrate
Atorvastatin Impurity 127
Ethyl (R)-(-)-4-cyano-3-hydroxybutyate fandachem
(3R)-4-Cyano-3-hydroxybutanoic Acid Ethyl
(R)-(-)-4-CYANO-3-HYDROXYBUTYATE
(3R)-4-Cyano-3-hydroxybutyric Acid Ethyl EsterQ: What is
(3R)-4-Cyano-3-hydroxybutyric Acid Ethyl Ester Q: What is the CAS Number of
(3R)-4-Cyano-3-hydroxybutyric Acid Ethyl Ester Q: What is the storage condition of
(3R)-4-Cyano-3-hydroxybutyric Acid Ethyl Ester
141942-85-0
41942-85-0
NCCH2CHOHCH2CO2C2H5
Organic Building Blocks
Esters