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Ranolazine

Description References
Ranolazine
Ranolazine structure
CAS No.
95635-55-5
Chemical Name:
Ranolazine
Synonyms
Ranexa;Renexa;CVT 303;RANOLAZINE;RS 43285-003;Ranolazine(Ranexa);Ranolazine (100 mg);1- 3-(2-Methoxyphenoxy)-2-hydroxypropyl -4- ...;1-Piperazineacetamide,N-(2,6-dimethylphenyl)-4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]-;n-(2,6-dimethylphenyl)-2-[4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]piperazin-1-yl]acetamide
CBNumber:
CB5195172
Molecular Formula:
C24H33N3O4
Formula Weight:
427.54
MOL File:
95635-55-5.mol

Ranolazine Properties

Melting point:
119-1200C
storage temp. 
-20°C Freezer
CAS DataBase Reference
95635-55-5(CAS DataBase Reference)

SAFETY

Ranolazine price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy

Ranolazine Chemical Properties,Uses,Production

Description

Ranolazine ([(+)N-(2,6-dimethylphenyl)-4(2-hydroxy-3-(2-methoxyphenoxy)-propyl)-1-piperazine acetamide dihydrochloride]) is an active piperazine derivative that was patented in 1986 and is available in an oral and intravenous form. Ranolazine is evidenced with anti-ischemic/antianginal properties in patients with chronic angina without clinically significant changes in heart rate or blood pressure.  
Ranolazine is used for the treatment of angina (chronic chest pain). Researches show it also has potential use in cardiovascular conditions such as heart failure, acute and chronic myocardial ischemia, certain types of cardiac sodium channel gene mutations, and ventricular and supraventricular arrhythmias.

References

[1] Bernard R. Chaitman, Ranolazine for the Treatment of Chronic Angina and Potential Use in Other Cardiovascular Conditions, New Drugs and Technologies, 2006, vol. 113, 2462-2472
[2] Bernard R. Chaitman, Sandra L. Skettino, John O. Parker, Peter Hanley, Jaroslav Meluzin, Jerzy Kuch and Carl J. Pepine, Anti-ischemic effects and long-term survival during ranolazine monotherapy in patients with chronic severe angina, Journal of the American College of Cardiology, 2004, vol. 43, 1375-1382

Description

Ranolazine is an orally available, extended release drug for the treatment of chronic angina in patients who have failed to respond to prior angina therapy. Chronic stable angina (CSA) is a common symptom of coronary artery disease wherein plaques in the coronary vasculature restrict blood flow to the heart, which in turn leads to insufficient oxygenation of the heart, typically during physical exertion or emotional stress. A vast majority of the existing anti-anginal and anti-ischemic therapies aim to correct the imbalance between myocardial oxygen demand and supply through mechanisms that produce reductions in heart rate or blood pressure.

Chemical Properties

White Solid

Originator

Roche Bioscience (US)

Uses

antianginal, antiischemic

Uses

Ranolazine is an anti-ischemic agent which modulates myocardial metabolism. Antianginal.

brand name

Ranexa (Sensus).

General Description

Ranolazine, N-(2,6-dimethylphenyl)-2-[4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]piperazin-1-yl]acetamide (Ranexa), is an antianginal medication thatwas approved by the Food and Drug Administration (FDA)in January 2006 for the treatment of chronic angina.Ranolazine is believed to elicit its effects by altering thetranscellular late sodium current. This, in turn, alters thesodium-dependent calcium channels during myocardial ischemia.Thus, ranolazine indirectly prevents the calciumoverload that is associated with cardiac ischemia.Ranolazine is metabolized by the cytochrome CYP3A enzymesin the liver.

Ranolazine Preparation Products And Raw materials

Raw materials

Preparation Products


Ranolazine Suppliers

Global( 197)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Jinan Shengqi pharmaceutical Co,Ltd
86+15552594168
christine@shengqipharm.com CHINA 553 58
Capot Chemical Co.,Ltd.
+86 (0)571-855 867 18
+86 (0)571-858 647 95 sales@capotchem.com China 19917 60
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21915 58
Beijing Cooperate Pharmaceutical Co.,Ltd.
+86-10-60279497 +86(0)15646567669
+86-10-60279497 sales01@cooperate-pharm.com CHINA 1529 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20675 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32451 55
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 24195 60
Xiamen AmoyChem Co., Ltd
+86 (0)592-605 1114
sales@amoychem.com CHINA 6373 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 25795 58
Hubei Jusheng Technology Co.,Ltd.
8615527864001
sales@jushengtech.com CHINA 20084 58

View Lastest Price from Ranolazine manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-03-02 Ranolazine
95635-55-5
US $0.00 / KG 10KG 98 10mt Jinan Shengqi pharmaceutical Co,Ltd
2018-12-23 Ranolazine
95635-55-5
US $2.00 / kg 1kg 99% 100kg career henan chemical co

95635-55-5(Ranolazine)Related Search:


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  • N-(2,6-dimethylphenyl)-2-[4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]piperazin-1-yl]ethanamide
  • N-(2,6-diMethylphenyl)-2-{4-[(2R)-2-hydroxy-3-(2-Methoxyphenoxy)propyl]piperazin-1-yl}acetaMide
  • Ranolazine(Ranexa)
  • 1- 3-(2-Methoxyphenoxy)-2-hydroxypropyl -4- ...
  • Ranolazine N-(2,6-Dimethylphenyl)-2-[4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]piperazin-1-yl]acetamide
  • Ranolazine (100 mg)
  • RANOLAZINE
  • n-(2,6-dimethylphenyl)-2-[4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]piperazin-1-yl]acetamide
  • 1-[3-(2-methoxyphenoxy)-2-hydroxypropyl]-4-[(2,6-dimethylphenyl)aminocarbonylmethy]piperazine
  • CVT 303
  • Ranexa
  • Renexa
  • RS 43285-003
  • 95635-55-5
  • 96535-55-5
  • -
  • Aromatics
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • RANEXA
  • Inhibitors
  • APIs
  • Antianginal
  • API
  • C24H33N3O4
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