5-CHLORO-2-IODOPYRIDINE
- CAS No.
- 244221-57-6
- Chemical Name:
- 5-CHLORO-2-IODOPYRIDINE
- Synonyms
- 2-IODO-5-CHLOROPYRIDINE;5-CHLORO-2-IODOPYRIDINE;2-Iodine-5-chloropyridine;5-Chloro-2-Iodine Pyridine;Pyridine, 5-chloro-2-iodo-;5-Chloro-2-iodopyridine,98%;5-CHLORO-2-IODOPYRIDINE ISO 9001：2015 REACH
- CBNumber:
- CB5198850
- Molecular Formula:
- C5H3ClIN
- Molecular Weight:
- 239.44
- MDL Number:
- MFCD07368864
- MOL File:
- 244221-57-6.mol
- MSDS File:
- SDS
| Melting point | 85-87 °C(Solv: hexane (110-54-3)) |
|---|---|
| Boiling point | 237.3±20.0 °C(Predicted) |
| Density | 2.052±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| pka | -0.44±0.10(Predicted) |
| form | Solid |
| Appearance | Off-white to light brown Solid |
| Water Solubility | Slightly soluble in water. |
| Sensitive | Light Sensitive |
| CAS DataBase Reference | 244221-57-6(CAS DataBase Reference) |
| UNSPSC Code | 12352200 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335-H302 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 22 | |||||||||
| HS Code | 2933399990 | |||||||||
| NFPA 704 |
|
5-CHLORO-2-IODOPYRIDINE price More Price(41)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SYX00319 | 5-Chloro-2-iodopyridine | 244221-57-6 | 1g | $179 | 2024-03-01 | Buy |
| Alfa Aesar | H64339 | 5-Chloro-2-iodopyridine, 98% | 244221-57-6 | 5g | $323 | 2021-12-16 | Buy |
| Alfa Aesar | H64339 | 5-Chloro-2-iodopyridine, 98% | 244221-57-6 | 1g | $71.6 | 2021-12-16 | Buy |
| TRC | C371605 | 5-Chloro-2-iodopyridine | 244221-57-6 | 50mg | $60 | 2021-12-16 | Buy |
| TRC | C371605 | 5-Chloro-2-iodopyridine | 244221-57-6 | 10mg | $45 | 2021-12-16 | Buy |
5-CHLORO-2-IODOPYRIDINE Chemical Properties,Uses,Production
Uses
It is applied in an efficient preparation of indolizines through a tandem palladium-catalyzed cross-coupling reaction and cycloisomerization and also in the synthesis, and structure-activity relationships of 2-aminoquinazoline derivatives as a novel class of metabotropic glutamate receptor 5 negative allosteric modulators.
Synthesis
40473-01-6
244221-57-6
General procedure for the synthesis of 5-chloro-2-iodopyridine from 2-bromo-5-chloropyridine: 1. Preparation: acetyl chloride (11.05 mL, 0.155 mol) was slowly added to a solution of 2-bromo-5-chloropyridine (20.0 g, 0.103 mol) in acetonitrile (120 mL) followed by sodium iodide (23.3 g, 0.155 mol). The reaction mixture was heated to reflux and a drying tube was fitted for 3 hours. 2. Post-treatment: after completion of the reaction, the mixture was cooled in an ice bath and saturated aqueous potassium carbonate solution was slowly added to alkalize the reaction solution. The reaction mixture was extracted with ethyl acetate (2 x 100 mL). The organic layers were combined, washed with saturated aqueous sodium sulfite (200 mL), dried over anhydrous magnesium sulfate and subsequently concentrated under reduced pressure. 3. Repeat the reaction: to ensure that the reaction was complete, the residue was subjected to the same reaction and post-treatment steps again. The target compound 5-chloro-2-iodopyridine (18.71 g, 75% yield) was finally obtained as a brown solid. 4. Characterization: 1H NMR (CDCl3, 400 MHz) δ 7.30 (1H, dd), 7.65 (1H, d), 8.35 (1H, d); LRMS (APCI+) m/z 240 [MH+].
References
[1] Tetrahedron, 2004, vol. 60, # 51, p. 11869 - 11874
[2] Patent: WO2007/96763, 2007, A2. Location in patent: Page/Page column 52
[3] Patent: WO2007/15162, 2007, A1. Location in patent: Page/Page column 91
[4] Patent: US2011/306592, 2011, A1. Location in patent: Page/Page column 92
5-CHLORO-2-IODOPYRIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| PNP Biotech Co. Ltd | +8618516098983 | sales@pnpbiotech.com | China | 1001 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20203 | 58 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 12835 | 58 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29855 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10406 | 58 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 8497 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
View Lastest Price from 5-CHLORO-2-IODOPYRIDINE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2025-04-04 | 5-CHLORO-2-IODOPYRIDINE
244221-57-6
|
US $0.00-0.00 / KG | 1KG | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd.
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2024-04-09 | 5-CHLORO-2-IODOPYRIDINE
244221-57-6
|
US $5.00-0.10 / KG | 1KG | 98% | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd | |
 |
2024-03-28 | 5-Chloro-2-iodopyridine
244221-57-6
|
US $0.00 / kg | 25kg | 98% | Inquiry | PNP Biotech Co. Ltd |
-
- 5-CHLORO-2-IODOPYRIDINE
244221-57-6
- US $0.00-0.00 / KG
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- 5-CHLORO-2-IODOPYRIDINE
244221-57-6
- US $5.00-0.10 / KG
- 98%
- Henan Fengda Chemical Co., Ltd
-
- 5-Chloro-2-iodopyridine
244221-57-6
- US $0.00 / kg
- 98%
- PNP Biotech Co. Ltd
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