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LY 367385

CAS No.
198419-91-9
Chemical Name:
LY 367385
Synonyms
LY 367385;LY367385,LY-367385;LY-367385 hydrochloride;SGIKDIUCJAUSRD-QMMMGPOBSA-N;(S)-4-[aMino(carboxy)Methyl]-3-Methylbenzoic acid;(S)-(+)-α-Amino-4-carboxy-2-methylbenzeneaceticacid;(S)-(+)-a-amino-4-carboxy-2-methylbenzeneacetic acid;(S)-(+)-α-Amino-4-carboxy-2-methylbenzeneacetic acid;Benzeneacetic acid, α-amino-4-carboxy-2-methyl-, (αS)-;Benzeneacetic acid, α-amino-4-carboxy-2-methyl-, (αS)-
CBNumber:
CB5200038
Molecular Formula:
C10H11NO4
Molecular Weight:
209.2
MDL Number:
MFCD02262124
MOL File:
198419-91-9.mol
MSDS File:
SDS
Last updated:2023-06-30 15:45:59

LY 367385 Properties

storage temp. Desiccate at RT
solubility H2O: >10mg/mL
form powder
color white to off-white
FDA UNII D8UW47H17B

SAFETY

Risk and Safety Statements

WGK Germany  3

LY 367385 price More Price(10)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich L4420 LY-367385 hydrochloride ≥98% (HPLC) 198419-91-9 5mg $86 2024-03-01 Buy
Sigma-Aldrich L4420 LY-367385 hydrochloride ≥98% (HPLC) 198419-91-9 25mg $326 2024-03-01 Buy
Tocris 1237 LY367385 ≥99%(HPLC) 198419-91-9 50 $802 2021-12-16 Buy
Tocris 1237 LY367385 ≥99%(HPLC) 198419-91-9 10 $191 2021-12-16 Buy
TRC L486690 LY367385 198419-91-9 25mg $235 2021-12-16 Buy
Product number Packaging Price Buy
L4420 5mg $86 Buy
L4420 25mg $326 Buy
1237 50 $802 Buy
1237 10 $191 Buy
L486690 25mg $235 Buy

LY 367385 Chemical Properties,Uses,Production

Uses

LY 367385 is a selective mGlu1a receptor antagonist used to treat inflammatory diseases (ie. multiple sclerosis) and neurodegenerative diseases (ie. Alzheimer’s) (1,2).

Biological Activity

A selective mGlu 1a receptor antagonist, with an IC 50 value of 8.8 μ M for blockade of quisqualate-induced phosphoinositide hydrolysis vs. > 100 μ M for mGlu 5a , and negligible action on group II and III receptors. Also available as part of the Group I mGlu Receptor Tocriset™ .

Biochem/physiol Actions

LY-367385 hydrochloride has an ability to inhibit induction of long-term potentiation (LTP).

in vitro

compared with the activity of ly367385, the novel compound ly367366 antagonizes both mglu1a and -5 receptors at low micromolar concentrations, but also recruits other subtypes at higher concentrations. ly367366 possessing neuroprotective ability was in general less efficacious than ly357385. this fact suggested that inhibitors of mglu1 receptors is a potential agent to confer significant neuroprotection [1].

in vivo

ly 367385 and aida have been administered intracerebroventricularly (i.c.v.) to lethargic mice and dbar2 mice, and focally into the inferior colliculus of gepr. in lethargic mice both compounds significantly decrease the incidence of spontaneous spike and wave discharges on the electroencephalogram, after the administration of ly 367385, 250 nmol, i.c.v. ly 367385, 50 nmol, inhibites spontaneous spike and wave discharges from 30 to 60 min. in dbar2 mice both compounds produce a rapid, transient suppression of sound-induced clonic seizures. in genetically epilepsy prone rats, both compounds decreases sound-induced clonic seizures. the results suggestes that antagonists of mglu1 receptors are potential anticonvulsant tools and that activation of mglu1 receptors likely contributes to a variety of epilepticsyndromes [2].

IC 50

8.8 μm

storage

Room temperature (desiccate)

References

[1]. bruno v, battaglia g, kingston a, o'neill mj, catania mv, di grezia r, nicoletti f. neuroprotective activity of the potent and selective mglu1a metabotropic glutamate receptor antagonist, (+)-2-methyl-4 carboxyphenylglycine (ly367385): comparison with ly357366, a broader spectrum antagonist with equal affinity for mglu1a and mglu5 receptors. neuropharmacology. 1999 feb;38(2):199-207.
[2]. chapman ag, yip pk, yap js, quinn lp, tang e, harris jr, meldrum bs. anticonvulsant actions of ly 367385 ((+)-2-methyl-4-carboxyphenylglycine) and aida ((rs)-1-aminoindan-1,5-dicarboxylic acid). eur j pharmacol. 1999 feb 26;368(1):17-24.

LY 367385 Preparation Products And Raw materials

Raw materials

Preparation Products

LY 367385 Suppliers

Global( 46)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc.
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Wuhan Topule Biopharmaceutical Co., Ltd
+8618327326525 masar@topule.com China 8475 58
3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037 3bsc@sina.com China 15848 69
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Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51471 80
EMMX Biotechnology LLC 888-539-0666 info@emmx.com United States 8449 60
BOC Sciences -- info@bocsci.com USA 0 65
DC Chemicals 021-58447131 13564518121 sales@dcchemicals.com China 9414 58
MedBioPharmaceutical Technology Inc 021-69568360 18916172912 order@med-bio.cn China 8141 58
Energy Chemical 021-58432009 400-005-6266 marketing@energy-chemical.com China 44941 58
(S)-(+)-ALPHA-AMINO-4-CARBOXY-2-METHYLBENZENEACETIC ACID LY 367385 (S)-(+)-α-Amino-4-carboxy-2-methylbenzeneaceticacid (S)-4-[aMino(carboxy)Methyl]-3-Methylbenzoic acid (S)-(+)-a-amino-4-carboxy-2-methylbenzeneacetic acid LY-367385 hydrochloride (R)-(+)-alpha-Amino-4-carboxy-2-methylbenzeneacetic acid LY-367385;(R)-(+)-ALPHA-AMINO-4-CARBOXY-2-METHYLBENZENEACETIC ACID (S)-(+)-α-Amino-4-carboxy-2-methylbenzeneacetic acid Benzeneacetic acid, α-amino-4-carboxy-2-methyl-, (αS)- SGIKDIUCJAUSRD-QMMMGPOBSA-N LY367385,LY-367385 Benzeneacetic acid, α-amino-4-carboxy-2-methyl-, (αS)- 198419-91-9 Glutamate