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BEPHENIUM HYDROXYNAPHTHOATE

Pharmacology and mechanism of action Indications Side effects Contraindications Interactions Preparations References
BEPHENIUM HYDROXYNAPHTHOATE
BEPHENIUM HYDROXYNAPHTHOATE structure
CAS No.
3818-50-6
Chemical Name:
BEPHENIUM HYDROXYNAPHTHOATE
Synonyms
Bephenium;BEPHENIUM HYDROXYNAPTHOATE;BEPHENIUM HYDROXYNAPHTHOATE;3-hydroxynaphthalene-2-carboxylate;Bephenium Hydroxynaphthoate (500 mg);dimethyl-[2-(phenoxy)ethyl]-(phenylmethyl)azanium;BENZYLDIMETHYL[2-PHENOXYETHYL]-AMMONIUM 3-HYDROXYNAPHTHOATE;benzyldimethyl-2-phenoxyethylammonium 3-hydroxy-2-naphthoate
CBNumber:
CB5206454
Molecular Formula:
C28H29NO4
Formula Weight:
443.53
MOL File:
3818-50-6.mol

BEPHENIUM HYDROXYNAPHTHOATE Properties

Melting point:
170-171°
form 
neat

SAFETY

WGK Germany  3

BEPHENIUM HYDROXYNAPHTHOATE price More Price(1)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich B5650 Bephenium hydroxynaphthoate analytical standard 3818-50-6 10g $93.7 2018-11-20 Buy

BEPHENIUM HYDROXYNAPHTHOATE Chemical Properties,Uses,Production

Pharmacology and mechanism of action

Bephenium is a quaternary ammonium compound first introduced into clinical medicine in 1958. It has a wide anthelminthic activity, in particular against Ancylostoma duodenale and Ascaris lumbricoides.
The mechanism of action of bephenium is similar to that of pyrantel and levamisole (see the monograph on levamisole, p. 74).
 

Indications

Infections with Ancylostoma duodenale, Ascaris lumbricoides and Necator americanus. Superior alternative drugs are available today.
 

Side effects

The drug has a bitter taste which might cause some patients especially children to refuse intake or vomit. This may be minimized by giving the drug with a sweet drink. Some individuals experience transient nausea, vomiting and headache after drug intake. Vertigo is occasionally reported.
 

Contraindications

There are no known contraindications to the drug.
 

Interactions

Bephenium has antagonistic effects to piperazine. However, no interactions were reported when the two drugs were combined together during helminthic therapy [1].
 

Preparations

5 g bephenium hydroxynaphthoate contains 2.9 g bephenium.

• Alcopar® (Wellcome). Sachet containing 5 g of bephenium hydroxynaphthoate.

References

1. Goodwin LG, Jayewardene LG, Standen OD (1958). Clinical trials with bephenium hydroxynaphthoate against hookworm in Ceylon. BMJ, 2, 1572–1576.

Uses

antibacterial, antilepretic, antituberculosis

Uses

Bephenium Hydroxynapthoate is an anthelmintic agent used to treat hookworm infections and ascariasis.

BEPHENIUM HYDROXYNAPHTHOATE Preparation Products And Raw materials

Raw materials

Preparation Products


BEPHENIUM HYDROXYNAPHTHOATE Suppliers

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3818-50-6(BEPHENIUM HYDROXYNAPHTHOATE)Related Search:


  • BENZYLDIMETHYL[2-PHENOXYETHYL]-AMMONIUM 3-HYDROXYNAPHTHOATE
  • BEPHENIUM HYDROXYNAPHTHOATE
  • benzyldimethyl-2-phenoxyethylammonium 3-hydroxy-2-naphthoate
  • Bephenium
  • 3-hydroxynaphthalene-2-carboxylate
  • dimethyl-[2-(phenoxy)ethyl]-(phenylmethyl)azanium
  • Bephenium Hydroxynaphthoate (500 mg)
  • BEPHENIUM HYDROXYNAPTHOATE
  • 3818-50-6
  • C17H22NOC11H7O3
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