BEPHENIUM HYDROXYNAPHTHOATE
- CAS No.
- 3818-50-6
- Chemical Name:
- BEPHENIUM HYDROXYNAPHTHOATE
- Synonyms
- Bephenium;BEPHENIUM HYDROXYNAPTHOATE;BEPHENIUM HYDROXYNAPHTHOATE;3-hydroxynaphthalene-2-carboxylate;Bephenium Hydroxynaphthoate (500 mg);BEPHENIUM HYDROXYNAPHTHOATE USP/EP/BP;Bephenium Hydroxynaphthoate (1065006);dimethyl-[2-(phenoxy)ethyl]-(phenylmethyl)azanium;Bephenium (hydroxynaphthoate),Inhibitor,Parasite,inhibit;BENZYLDIMETHYL[2-PHENOXYETHYL]-AMMONIUM 3-HYDROXYNAPHTHOATE
- CBNumber:
- CB5206454
- Molecular Formula:
- C28H29NO4
- Molecular Weight:
- 443.53
- MDL Number:
- MFCD00078960
- MOL File:
- 3818-50-6.mol
- MSDS File:
- SDS
| Melting point | 170-171° |
|---|---|
| storage temp. | Store at -20°C |
| solubility | ≥ 20.85mg/mL in DMSO |
| FDA UNII | 47RU9546DX |
| ATC code | P02CX02 |
BEPHENIUM HYDROXYNAPHTHOATE price More Price(12)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | B5650 | Bephenium hydroxynaphthoate analytical standard | 3818-50-6 | 10g | $116 | 2022-05-15 | Buy |
| TRC | B317300 | BepheniumHydroxynapthoate | 3818-50-6 | 1g | $120 | 2021-12-16 | Buy |
| ApexBio Technology | A8376 | Bephenium hydroxynaphthoate | 3818-50-6 | 1g | $122 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0015105 | BEPHENIUM HYDROXYNAPHTHOATE 95.00% | 3818-50-6 | 100MG | $179.55 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb611385 | Bephenium hydroxynaphthoate | 3818-50-6 | 500mg | $200.6 | 2021-12-16 | Buy |
BEPHENIUM HYDROXYNAPHTHOATE Chemical Properties,Uses,Production
Pharmacology and mechanism of action
Bephenium is a quaternary ammonium compound first introduced into clinical medicine in 1958. It has a wide anthelminthic activity, in particular against Ancylostoma duodenale and Ascaris lumbricoides.
The mechanism of action of bephenium is similar to that of pyrantel and levamisole (see the monograph on levamisole, p. 74).
Indications
Infections with Ancylostoma duodenale, Ascaris lumbricoides and Necator americanus. Superior alternative drugs are available today.
Side effects
The drug has a bitter taste which might cause some patients especially children to refuse intake or vomit. This may be minimized by giving the drug with a sweet drink. Some individuals experience transient nausea, vomiting and headache after drug intake. Vertigo is occasionally reported.
Contraindications
There are no known contraindications to the drug.
Interactions
Bephenium has antagonistic effects to piperazine. However, no interactions were reported when the two drugs were combined together during helminthic therapy [1].
Preparations
5 g bephenium hydroxynaphthoate contains 2.9 g bephenium.
• Alcopar® (Wellcome). Sachet containing 5 g of bephenium hydroxynaphthoate.
References
1. Goodwin LG, Jayewardene LG, Standen OD (1958). Clinical trials with bephenium hydroxynaphthoate against hookworm in Ceylon. BMJ, 2, 1572–1576.
Uses
antibacterial, antilepretic, antituberculosis
Uses
Bephenium Hydroxynapthoate is an anthelmintic agent used to treat hookworm infections and ascariasis.
Indications
This drug exhibits antihelmintic action by acting as a cholinergic agonist, causing paralysis of the parasite musculature. This facilitates its removal from the intestines. It is used for treating ascariasis, ankylostomiasis, enterobiasis, trichostrongyliasis, and tricocefalosis. A single dose of bephenium heals from 80 to 100% of patients infected with A. duodenale. It is less effective with respect to N. americanus. Synonyms of this drug are aclopar and others.
Clinical Use
Bephenium can be used against Ascaris, Ancylostoma, and Trichostrongylus infections; it is less effective against Necator. Occasional adverse reactions occur: nausea, diarrhea, vomiting, headache, vertigo.
Synthesis
Bephenium, 3-hydroxy-2-naphthoat benzyldimethyl(2-phenoxyethyl) ammonia (38.1.37), is made by reacting the sodium salt of 3-hydroxy-2-naphthoic acid with benzyldimethyl(2-phenoxyethyl)ammonia chloride (38.1.36). This is in turn made from benzyl chloride and N-(2-phenoxyethyl)dimethylamine (38.1.35), which is synthesized by reacting sodium phenolate with 2-dimethylaminoethylchloride.
BEPHENIUM HYDROXYNAPHTHOATE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29271 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | product@acmec-e.com | China | 33349 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Sinopharm Chemical Reagent Co,Ltd. | 86-21-63210123 | sj_scrc@sinopharm.com | China | 9823 | 79 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7553 | 61 |
| Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 | isunpharm@qq.com | China | 4428 | 55 |
View Lastest Price from BEPHENIUM HYDROXYNAPHTHOATE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-06-19 | BEPHENIUM HYDROXYNAPHTHOATE USP/EP/BP
3818-50-6
|
US $1.10 / g | 1g | 99.9% | 100 Tons Min | Dideu Industries Group Limited |
-
- BEPHENIUM HYDROXYNAPHTHOATE USP/EP/BP
3818-50-6
- US $1.10 / g
- 99.9%
- Dideu Industries Group Limited
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