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Sodium carboxymethyl cellulose

Product Features Uses Usage Instruction
Sodium carboxymethyl cellulose
Sodium carboxymethyl cellulose structure
CAS No.
9004-32-4
Chemical Name:
Sodium carboxymethyl cellulose
Synonyms
b10;cmc2;s75m;7h3sf;carbo;cmc7h;cmc7m;Cellex;CMC-Na;cmc41a
CBNumber:
CB5209844
Molecular Formula:
C6H7O2(OH)2CH2COONa
Formula Weight:
0
MOL File:
Mol file

Sodium carboxymethyl cellulose Properties

Melting point:
274 °C (dec.)
Density 
1,6 g/cm3
FEMA 
2239 | CARBOXYMETHYLCELLULOSE
storage temp. 
room temp
solubility 
H2O: 20 mg/mL, soluble
pka
4.30(at 25℃)
form 
low viscosity
color 
White to light yellow
Odor
Odorless
PH
pH (10g/l, 25℃) 6.0~8.0
PH Range
6.5 - 8.5
Water Solubility 
soluble
Merck 
14,1829
Stability:
Stable. Incompatible with strong oxidizing agents.
Substances Added to Food (formerly EAFUS)
CARBOXYMETHYL CELLULOSE, SODIUM SALT
SCOGS (Select Committee on GRAS Substances)
Sodium Carboxymethyl cellulose
EWG's Food Scores
1
EPA Substance Registry System
Sodium carboxymethyl cellulose (9004-32-4)
SAFETY
  • Risk and Safety Statements
Risk Statements  40
Safety Statements  24/25
WGK Germany  1
RTECS  FJ5950000
3
Autoignition Temperature 698 °F
TSCA  Yes
HS Code  39123100
Toxicity LD50 oral in rabbit: > 27gm/kg

Sodium carboxymethyl cellulose price More Price(30)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 17851-M Aquacide II 9004-32-4 1kg-m $90.5 2019-12-02 Buy
Sigma-Aldrich 1096553 Carboxymethylcellulose sodium United States Pharmacopeia (USP) Reference Standard 9004-32-4 1.5g $399.35 2019-12-02 Buy
TCI Chemical C0045 Carboxymethyl Cellulose Sodium n(=:)500 9004-32-4 25g $20 2020-06-24 Buy
TCI Chemical C0045 Carboxymethyl Cellulose Sodium n(=:)500 9004-32-4 500g $51 2020-06-24 Buy
Alfa Aesar A18105 Carboxymethylcellulose sodium salt 9004-32-4 500g $60 2020-06-24 Buy

Sodium carboxymethyl cellulose Chemical Properties,Uses,Production

Product Features

Carboxymethyl cellulose (CMC) is tackifier, at room temperature, it is non-toxic tasteless white flocculent powder, it is stable and soluble in water, aqueous solution is neutral or alkaline transparent viscous liquid, it is soluble in other water-soluble gums and resins, it is insoluble in organic solvents such as ethanol. Carboxymethyl cellulose is the substituted product of cellulosic carboxymethyl group. According to their molecular weight or degree of substitution, it can be completely dissolved or insoluble polymer, the latter can be used as the weak acid cation of exchanger to separate neutral or basic proteins.
Carboxymethyl cellulose can form highly viscous colloidal solution with adhesive, thickening, flowing, emulsifying, shaping, water, protective colloid, film forming, acid, salt, suspensions and other characteristics, and it is physiologically harmless, so it is widely used in the food, pharmaceutical, cosmetic, oil, paper, textiles, construction and other areas of production.

Uses

It is used in cigarette adhesive, fabric sizing, footwear paste meal, home slimy. It is used in interior painting architectural, building lines melamine, thickening mortar, concrete enhancement. It is used in refractory fiber, ceramic production molding bond. It is used in oil drilling, exploration address slurry thickening, reducing water loss, quality paper surface sizing. It can be used as soap and washing powder detergent active additives, as well as other industrial production on the dispersion, emulsification, stability, suspension, film, paper, polishing and the like. Quality product can be used for toothpaste, medicine, food and other industrial sectors.
CMC can significantly increase the viscosity of the solution as thickener, dispersion, emulsification, suspension, protective colloid and so on when it is dissolved in water, and it is physiologically harmless, it is widely used in the food, pharmaceutical, cosmetic, oil, paper, textiles, construction and other areas of production.

Usage Instruction

Use warm water or cold water when preparing the solution, and stir till it completely melts. The amout of added water depends on variety and the use of multiple requirements.
High viscosity sodium carboxymethyl cellulose (HV-CMC) is a white or slightly yellow fibrous powder, hygroscopic, odorless, tasteless, non-toxic, easy to ferment, insoluble in acids, alcohols and organic solvents, easily dispersed to form colloidal solution in water. It is reacted by the acid and fibrous cotton, it is mainly used for water-based drilling fluids tackifier, it has certain role of fluid loss, it has strong salt and temperature resistance especially.

Chemical Properties

solid

Chemical Properties

Carboxymethylcellulose sodium occurs as a white to almost white, odorless, tasteless, granular powder. It is hygroscopic after drying.

Uses

cellulose gum (Carboxymethyl cellulose) is a thickener, binder, and emulsifier equivalent to cellulose fiber. It is resistant to bacterial decomposition and provides a product with uniform viscosity. It can prevent skin moisture loss by forming a film on the skin’s surface, and also help mask odor in a cosmetic product. Constituents are any of several fibrous substances consisting of the chief part of a plant’s cell walls (often extracted from wood pulp or cotton).

Uses

In drilling muds, in detergents as a soil-suspending agent, in resin emulsion paints, adhesives, printing inks, textile sizes, as protective colloid in general. As stabilizer in foods. Pharmaceutic aid (suspending agent; tablet excipient; viscosity-increasing agent).

Definition

A semisynthetic, water-soluble polymer in which CH 2 COOH groups are substituted on the glucose units of the cellulose chain through an ether link- age. Mw ranges from 21,000 to 500,000. Since the reaction occurs in an alkaline medium, the prod- uct is the sodium salt of the carboxylic acid R-O- CH 2 COONa.

Production Methods

Alkali cellulose is prepared by steeping cellulose obtained from wood pulp or cotton fibers in sodium hydroxide solution. The alkaline cellulose is then reacted with sodium monochloroacetate to produce carboxymethylcellulose sodium. Sodium chloride and sodium glycolate are obtained as by-products of this etherification.

brand name

Celluvisc (Allergan); Refresh Plus, Cellufresh Formula (Allergan).

Pharmaceutical Applications

Carboxymethylcellulose sodium is widely used in oral and topical pharmaceutical formulations, primarily for its viscosity-increasing properties. Viscous aqueous solutions are used to suspend powders intended for either topical application or oral and parenteral administration. Carboxymethylcellulose sodium may also be used as a tablet binder and disintegrant, and to stabilize emulsions.
Higher concentrations, usually 3–6%, of the medium-viscosity grade are used to produce gels that can be used as the base for applications and pastes; glycols are often included in such gels to prevent them drying out. Carboxymethylcellulose sodium is also used in self-adhesive ostomy, wound care, and dermatological patches as a muco-adhesive and to absorb wound exudate or transepidermal water and sweat. This muco-adhesive property is used in products designed to prevent post-surgical tissue adhesions; and to localize and modify the release kinetics of active ingredients applied to mucous membranes; and for bone repair. Encapsulation with carboxymethylcellulose sodium can affect drug protection and delivery. There have also been reports of its use as a cyto-protective agent.
Carboxymethylcellulose sodium is also used in cosmetics, toiletries, surgical prosthetics, and incontinence, personal hygiene, and food products.

Safety Profile

Mildly toxic by ingestion. Experimental reproductive effects. Questionable carcinogen with experimental neoplastigenic data. It migrates to food from packagmg materials. When heated to decomposition it emits toxic fumes of NazO. See also POLYMERS, SOLUBLE.

Safety

Carboxymethylcellulose sodium is used in oral, topical, and some parenteral formulations. It is also widely used in cosmetics, toiletries, and food products, and is generally regarded as a nontoxic and nonirritant material. However, oral consumption of large amounts of carboxymethylcellulose sodium can have a laxative effect; therapeutically, 4–10 g in daily divided doses of the medium- and high-viscosity grades of carboxymethylcellulose sodium have been used as bulk laxatives.
The WHO has not specified an acceptable daily intake for carboxymethylcellulose sodium as a food additive since the levels necessary to achieve a desired effect were not considered to be a hazard to health. However, in animal studies, subcutaneous administration of carboxymethylcellulose sodium has been found to cause inflammation, and in some cases of repeated injection fibrosarcomas have been found at the site of injection.
Hypersensitivity and anaphylactic reactions have occurred in cattle and horses, which have been attributed to carboxymethylcellulose sodium in parenteral formulations such as vaccines and penicillins.
LD50 (guinea pig, oral): 16 g/kg
LD50 (rat, oral): 27 g/kg

storage

Carboxymethylcellulose sodium is a stable, though hygroscopic material. Under high-humidity conditions, carboxymethylcellulose sodium can absorb a large quantity (>50%) of water. In tablets, this has been associated with a decrease in tablet hardness and an increase in disintegration time.
Aqueous solutions are stable at pH 2–10; precipitation can occur below pH 2, and solution viscosity decreases rapidly above pH 10. Generally, solutions exhibit maximum viscosity and stability at pH 7–9.
Carboxymethylcellulose sodium may be sterilized in the dry state by maintaining it at a temperature of 1608℃ for 1 hour. However, this process results in a significant decrease in viscosity and some deterioration in the properties of solutions prepared from the sterilized material.
Aqueous solutions may similarly be sterilized by heating, although this also results in some reduction in viscosity. After autoclaving, viscosity is reduced by about 25%, but this reduction is less marked than for solutions prepared from material sterilized in the dry state. The extent of the reduction is dependent on the molecular weight and degree of substitution; higher molecular weight grades generally undergo a greater percentage reduction in viscosity. Sterilization of solutions by gamma irradiation also results in a reduction in viscosity.
Aqueous solutions stored for prolonged periods should contain an antimicrobial preservative.
The bulk material should be stored in a well-closed container in a cool, dry place.

Purification Methods

Dialyse it for 48hours against distilled water and freeze-dry if a solid is required.

Incompatibilities

Carboxymethylcellulose sodium is incompatible with strongly acidic solutions and with the soluble salts of iron and some other metals, such as aluminum, mercury, and zinc. It is also incompatible with xanthan gum. Precipitation may occur at pH < 2, and also when it is mixed with ethanol (95%).
Carboxymethylcellulose sodium forms complex coacervates with gelatin and pectin. It also forms a complex with collagen and is capable of precipitating certain positively charged proteins.

Regulatory Status

GRAS listed. Accepted as a food additive in Europe. Included in the FDA Inactive Ingredients Database (dental preparations; intraarticular, intrabursal, intradermal, intralesional, and intrasynovial injections; oral drops, solutions, suspensions, syrups and tablets; topical preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Nonmedicinal Ingredients.

Sodium carboxymethyl cellulose Preparation Products And Raw materials

Raw materials

Preparation Products


Sodium carboxymethyl cellulose Suppliers

Global( 395)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Dalian Richfortune Chemicals Co., Ltd
0411-84820922
86-411-84821380 sales@richfortunechem.com;sales@richfortunechem.com China 338 57
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22625 55
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 2680 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30043 58
Hebei Huanhao Biotechnology Co., Ltd.
+8618034552304
86-0311-83975816 cathylee@hbhuanhao.com CHINA 865 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23977 58
Haihang Industry Co.,Ltd
86-531-88032799
+86 531 8582 1093 export@haihangchem.com CHINA 10154 58
hdzhl biotechnology co., ltd
86-13032617415
sales@luchibiology.com CHINA 1277 58
Chongqing Chemdad Co.,Ltd
+86-19923101450
sales@chemdad.com CHINA 4001 58
Xiamen AmoyChem Co., Ltd
+86 592-605 1114
sales@amoychem.com CHINA 6371 58

View Lastest Price from Sodium carboxymethyl cellulose manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2020-07-13 Carboxymethylcellulose sodium;CMC
9004-32-4
US $2.00 / Kg/Bag 1T 99% 500tons/month Hebei Yanxi Chemical Co., Ltd.
2019-04-02 Carboxymethyl cellulose Manufacturer; In stock GMP Factory
9004-32-4
US $1.00 / KG 1KG High quality manufacturer TOP 3 largest production factory in China Chemwill Asia Co.,Ltd.
2018-08-01 Carboxymethyl cellulose
9004-32-4
US $150.00 / KG 1KG 99% 1000kg career henan chemical co

Sodium carboxymethyl cellulose Spectrum


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