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LEVOBUNOLOL

LEVOBUNOLOL Structure
LEVOBUNOLOL structure
CAS No.
47141-42-4
Chemical Name:
LEVOBUNOLOL
Synonyms
W 6421A;AK-Beta;Betegan;l-Bunolol;Liquifilm;LEVOBUNOLOL;Levobunololum;LEVOBUNOLOL USP/EP/BP;[(-)-5-[3,(t-Butylamino)-2-hydroxy-propoxy]-3,4-di,HCl;5-[3-(tert-Butylamino)-2β-hydroxypropyloxy]-3,4-dihydronaphthalen-1(2H)-one
CBNumber:
CB5210167
Molecular Formula:
C17H25NO3
Molecular Weight:
291.39
MDL Number:
MFCD00864586
MOL File:
47141-42-4.mol
MSDS File:
SDS
Last updated:2022-12-21 16:56:50
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LEVOBUNOLOL Properties

Melting point 209-211°C
storage temp. -20°C Freezer, Under Inert Atmosphere
CAS DataBase Reference 47141-42-4(CAS DataBase Reference)
FDA UNII G6317AOI7K
ATC code S01ED03

SAFETY

Risk and Safety Statements

Toxicity LD50 in male, female rats, mice (mg/kg): 700, 800, 1530, 1220 orally; 25, 28, 78, 84 i.v.; LD50 in male, female hamsters, dogs (mg/kg): 435, 500, 100, 100 orally (Kaplan, 1980)

LEVOBUNOLOL price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
American Custom Chemicals Corporation API0003156 LEVOBUNOLOL 95.00% 47141-42-4 1G $630 2021-12-16 Buy
Medical Isotopes, Inc. 11354 LevobunololHCl 47141-42-4 1.25g $1560 2021-12-16 Buy
American Custom Chemicals Corporation API0003156 LEVOBUNOLOL 95.00% 47141-42-4 2.5G $1947 2021-12-16 Buy
AHH MT-53190 Levobunolol 98% 47141-42-4 5g $510 2021-12-16 Buy
Chemenu CM129099 (S)-5-(3-(tert-butylamino)-2-hydroxypropoxy)-3,4-dihydronaphthalen-1(2H)-one 95% 47141-42-4 1g $327 2021-12-16 Buy
Product number Packaging Price Buy
API0003156 1G $630 Buy
11354 1.25g $1560 Buy
API0003156 2.5G $1947 Buy
MT-53190 5g $510 Buy
CM129099 1g $327 Buy

LEVOBUNOLOL Chemical Properties,Uses,Production

Chemical Properties

White Solid

Originator

Betagan,Allergan,India

Uses

Levobunolol hydrochloride is an antiglaucoma agent in ophthalmie solutions.

Uses

As a non-selective adrenoceptor antagonist, Levobunolol is used as an anticonvulsant.

Definition

ChEBI: A cyclic ketone that is 3,4-dihydronaphthalen-1-one substituted at position 5 by a 3-(tert-butylamino)-2-hydroxypropoxy group (the S-enantiomer). A non-selective beta-adrenergic antagonist used (as its hydrochlo ide salt) for treatment of glaucoma.

Manufacturing Process

9.62 g (59 mmoles) 5-hydroxy-3,4-dihydro-1(2H)-naphthalenone, 67 ml toluene, 0.36 g (1.1 mmoles) tetra-n-butylammonium bromide, 4.51 g (68 mmoles) 85% potassium hydroxide and 20 ml (254 mmoles) (R)-(-)- epichlorhydrine were placed in an appropriate flask fitted with efficient mechanical stirring, and the mixture was heated under reflux for two hours. The mixture was allowed to cool to 30°C, 50 ml toluene and 50 ml water were added and the mixture was vigorously stirred. The organic phase was removed and the aqueous phase extracted with 25 ml toluene. The combined organic phases were concentrated at reduced pressure, 31 ml (300 mmoles) tert-butylamine, 45 ml ethanol and 3 ml deionized water were added, and the solution was heated under reflux for one hour. The mixture was allowed to cool to 40°C and the volatile products were distilled at reduced pressure. Toluene (9 ml) was added to the residue and volatiles were distilled at reduced pressure. (S)-5-(2,3-Epoxypropoxy)-3,4-dihydro-1(2H)- naphthalenone with an optical purity greater than 95% was obtained. Toluene (75 ml) was added to the product, and then, 10 ml of 35% (w/v) hydrochloric acid and 110 ml water, and the mixture was stirred for fifteen minutes. The organic phase was decanted and the aqueous one was extracted with 50 ml toluene. The aqueous phase was basified by addition of a solution of 5.1 g sodium hydroxide in 150 ml water and extracted twice with toluene (100 and 50 ml, respectively). The combined organic extracts were dried with anhydrous sodium sulfate, decolorized with active charcoal and filtered.
To the above toluenic solution containing levobunolol as free base, 16 ml ethanol and the stoichiometric amount of hydrogen chloride were added. The stirred mixture was cooled below 10°C and kept at this temperature for one hour. The precipitated solid was filtered, washed with toluene, recrystallized twice from 43 ml ethanol and dried to give 10.0 g (51% yield) of (-)-3,4- dihydro-5-(3-(tert-butylamino)-2-hydroxypropoxy)-1(2H)-naphthalenone hydrochloride (levobunolol hydrochloride) having a rotary power at 25°C below -19°.

brand name

Akbeta(Akorn); Betagan(Allergan).

Therapeutic Function

Beta-adrenergic blocker

LEVOBUNOLOL Preparation Products And Raw materials

Raw materials

4-(3,4-Dichlorophenyl)-1-tetralone tert-Butylamine 1-Tetralone Potassium hydroxide Tetrabutylammonium bromide

Preparation Products

LEVOBUNOLOL Suppliers

Global( 26)Suppliers
Supplier Tel Email Country ProdList Advantage
Shaanxi Dideu Medichem Co. Ltd 		+86-29-87569265 +86-18612256290 1056@dideu.com China 3683 58
Shaanxi Dideu Medichem Co. Ltd 		+86-029-89586680 +86-18192503167 1026@dideu.com China 9409 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1026@dideu.com China 29322 58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		+86-057181025280; +8617767106207 sales@molcore.com China 49739 58
TargetMol Chemicals Inc. 		+1-781-999-5354 support@targetmol.com United States 19973 58
Mainchem Co., Ltd. +86-0592-6210733 sale@mainchem.com China 32360 55
LGM Pharma 1-(800)-881-8210 inquiries@lgmpharma.com United States 2127 70
Chemsky (shanghai) International Co.,Ltd 021-50135380 shchemsky@sina.com China 15421 60
Beijing HuaMeiHuLiBiological Chemical 010-56205725 waley188@sohu.com China 12338 58
Shanghai Han-Xiang Chemical Co., Ltd. 15971444841 amber@biochempartner.com China 3063 58
Supplier Advantage
Shaanxi Dideu Medichem Co. Ltd 		58
Shaanxi Dideu Medichem Co. Ltd 		58
Dideu Industries Group Limited 		58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		58
TargetMol Chemicals Inc. 		58
Mainchem Co., Ltd. 55
LGM Pharma 70
Chemsky (shanghai) International Co.,Ltd 60
Beijing HuaMeiHuLiBiological Chemical 58
Shanghai Han-Xiang Chemical Co., Ltd. 58

View Lastest Price from LEVOBUNOLOL manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
LEVOBUNOLOL USP/EP/BP pictures 2021-08-12 LEVOBUNOLOL USP/EP/BP
47141-42-4
 US $1.10 / g 1g 99.9% 100 Tons min Dideu Industries Group Limited
Levobunolol pictures 2021-07-20 Levobunolol
47141-42-4
 US $1.00-1.00 / KG 1g 99% 50tons Shaanxi Dideu Medichem Co. Ltd
  • Levobunolol pictures
  • Levobunolol
    47141-42-4
  • US $1.00-1.00 / KG
  • 99%
  • Shaanxi Dideu Medichem Co. Ltd

47141-42-4(LEVOBUNOLOL)Related Search:

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toliprolol Dihydroalprenolol Bunolol (2S)-(-)-1-AMINO-3-PHENOXY-2-PROPANOL Xibenolol
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LEVOBUNOLOL

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LEVOBUNOLOL 5-[(2S)-3-[(1,1-Dimethylethyl)amino]-2-hydroxypropoxy]-3,4-dihydro-1(2H)-naphthalenone 5-[(S)-3-[(1,1-Dimethylethyl)amino]-2-hydroxypropoxy]-3,4-dihydronaphthalen-1(2H)-one 5-[3-(tert-Butylamino)-2β-hydroxypropyloxy]-3,4-dihydronaphthalen-1(2H)-one (S)-5-[3-[(1,1-DiMethylethyl)aMino]-2-hydroxypropoxy]- 3,4-dihydro-1(2H)-naphthalenone l-Bunolol W 6421A [(-)-5-[3,(t-Butylamino)-2-hydroxy-propoxy]-3,4-di,HCl 5-[(2S)-3-(tert-butylamino)-2-hydroxypropoxy]-3,4-dihydro-2H-naphthalen-1-one 1(2H)-Naphthalenone, 5-[(2S)-3-[(1,1-dimethylethyl)amino]-2-hydroxypropoxy]-3,4-dihydro- LEVOBUNOLOL USP/EP/BP AK-Beta Betegan Levobunololum Liquifilm 47141-42-4 27912-17-4 Intermediates & Fine Chemicals Pharmaceuticals