Zoledronic acid hydrate
- CAS No.
- 165800-06-6
- Chemical Name:
- Zoledronic acid hydrate
- Synonyms
- ZOLEDRONIC ACID MONOHYDRATE;ZoL;Acid, the;oledronic acid;Zoledronic Acid H2O;ZOL 446 monohydrate;CGP 42446 monohydrate;CGP42446A monohydrate;Zoledronate monohydrate;zoledronic acid hydrate
- CBNumber:
- CB5211391
- Molecular Formula:
- C5H12N2O8P2
- Molecular Weight:
- 290.1
- MDL Number:
- MFCD08448695
- MOL File:
- 165800-06-6.mol
- MSDS File:
- SDS
| Melting point | 245 °C(dec.) |
|---|---|
| storage temp. | 2-8°C |
| solubility | H2O: ≥2mg/mL |
| form | powder |
| color | white to beige |
| Merck | 14,10187 |
| InChIKey | FUXFIVRTGHOMSO-UHFFFAOYSA-N |
| CAS DataBase Reference | 165800-06-6(CAS DataBase Reference) |
| FDA UNII | 6XC1PAD3KF |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | SZ8562450 | |||||||||
| HS Code | 29332900 | |||||||||
| NFPA 704 |
|
Zoledronic acid hydrate price More Price(37)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0223 | Zoledronic acid monohydrate ≥98% (HPLC) | 165800-06-6 | 10mg | $112 | 2024-03-01 | Buy |
| Sigma-Aldrich | 1724827 | Zoledronic acid United States Pharmacopeia (USP) Reference Standard | 165800-06-6 | 150mg | $436 | 2024-03-01 | Buy |
| TCI Chemical | Z0031 | Zoledronic Acid Monohydrate >98.0%(HPLC)(T) | 165800-06-6 | 1g | $122 | 2024-03-01 | Buy |
| TCI Chemical | Z0031 | Zoledronic Acid Monohydrate >98.0%(HPLC)(T) | 165800-06-6 | 5g | $410 | 2024-03-01 | Buy |
| Cayman Chemical | 14984 | Zoledronic Acid (hydrate) ≥95% | 165800-06-6 | 25mg | $68 | 2024-03-01 | Buy |
Zoledronic acid hydrate Chemical Properties,Uses,Production
Uses
Zoledronic acid monohydrate is an anti-resorptive agent for cancer bone metasis, also used on studies in the environmental risk asseessment of drugs from view of excretion form to environment.
Uses
A highly potent bisphosphonate and activator of PKC.
brand name
Zometa (Novartis).
General Description
Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards
Biological Activity
Zoledronic acid (Zoledronate, CGP-4244) monohydrate is the monohydrate of Zoledronic acid (Zoledronic acid), a potent osteoclast inhibitor that inhibits small GTP-binding proteins by inhibiting enzymes of the mevalonate pathway Such as the prenylation of Ras and Rho to induce osteoclast apoptosis.
Biochem/physiol Actions
Zoledronic acid (zoledronate) is a bisphosphonate bone resorption inhibitor, an inhibitor of farnesyl diphosphate (FPP) synthase which results in downstream inhibition of osteoclast activity and reduced bone resorption and turnover. It has been used to treat postmenopausal osteoporosis, Paget′s disease, hypercalcemia, and along with cancer chemotherapy to treat bone damage caused by cancer that has spread to the bones.
in vitro
Zoledronic Acid monohydrate (0.1-1 μM; 48 hours) increases receptor activator of nuclear factor kB ligand (RANKL) and sclerostin mRNA expressions in osteocyte-like MLO-Y4 cells.Zoledronic Acid monohydrate increases the expression of osteoclastogenesis supporting factor from MLO-Y4 cells.Zoledronic Acid monohydrate enhances the RANKL expression via IL-6/ JAK2/STAT3 pathway in MLO-Y4 cells.Zoledronic Acid monohydrate inhibits osteoclast differentiation and function through the regulation of NF-κB and JNK signalling pathways.Zoledronic Acid monohydrate (10-100 μM; 1-7 days) markedly reduces the viability of MC3T3-E1 cells.Zoledronic Acid monohydrate (10-100 μM; 1-7 days) induces apoptosis in MC3T3-E1 cells.Zoledronic Acid monohydrate (10-100 μM; 4 days) inhibits cell viability due to the induction of apoptosis.Zoledronic Acid monohydrate exerts inhibitory effects on the differentiation and maturation of MC3T3-E1 cells at concentrations <1 μM.
in vivo
Zoledronic Acid monohydrate (0.05 mg/kg; i.p.; weekly; for 3 weeks) increases bone mineral density and content.Zoledronic Acid monohydrate (0.5-1 mg/kg; i.p.; weekly; for 3 weeks) inhibits both osteoclast and osteoblasts function and bone remodeling in vivo interfering with bone mechanical properties.
Zoledronic acid hydrate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Bao Enluo International TradeCo.，LTD | +86-17331933971 +86-17331933971 | deasea125996@gmail.com | China | 2503 | 58 |
| SHANDONG BOYUAN PHARMACEUTICAL CO., LTD. | +86-0531-69954981 +8615666777973 | dwyane.wang@boyuanpharm.com | China | 211 | 58 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Jinan Shengqi pharmaceutical Co,Ltd | 86+18663751872 | christine@shengqipharm.com | CHINA | 491 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-592-6051114 +8618959220845 | sales@amoychem.com | China | 6387 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
| Antai Fine Chemical Technology Co.,Limited | 18503026267 | info@antaichem.com | CHINA | 9641 | 58 |
| Neostar United (Changzhou) Industrial Co., Ltd. | +86-519-519-85557386 | marketing1@neostarunited.com | China | 8349 | 58 |
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12456 | 58 |
View Lastest Price from Zoledronic acid hydrate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-11-01 | Zoledronic acid hydrate
165800-06-6
|
US $0.00-0.00 / kg | 1kg | 99.0% min | 1000kgs/month | Hangzhou ICH Biofarm Co., Ltd | |
 |
2023-09-07 | Zoledronic acid hydrate
165800-06-6
|
US $0.00-0.00 / kg | 1kg | 99.9% HLPC | 1000 | SHANDONG BOYUAN PHARMACEUTICAL CO., LTD. | |
 |
2023-08-15 | Zoledronic acid hydrate
165800-06-6
|
US $80.00 / kg | 1kg | 99% | 1000tons | Henan Bao Enluo International TradeCo.，LTD |
-
- Zoledronic acid hydrate
165800-06-6
- US $0.00-0.00 / kg
- 99.0% min
- Hangzhou ICH Biofarm Co., Ltd
-
- Zoledronic acid hydrate
165800-06-6
- US $0.00-0.00 / kg
- 99.9% HLPC
- SHANDONG BOYUAN PHARMACEUTICAL CO., LTD.
-
- Zoledronic acid hydrate
165800-06-6
- US $80.00 / kg
- 99%
- Henan Bao Enluo International TradeCo.，LTD