corticorelin ovine
- CAS No.
- 121249-14-7
- Chemical Name:
- corticorelin ovine
- Synonyms
- corticorelin ovine;Corticorelin ovine triflutate;CRF (ovine) Corticorelin (ovine)
- CBNumber:
- CB52130412
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
| FDA UNII | 56X54T817Q |
|---|---|
| NCI Drug Dictionary | corticorelin ovine triflutate |
corticorelin ovine Chemical Properties,Uses,Production
Uses
Diagnostic aid(adrenocortical insufficiency); diagnostic aid (Cushing’s syndrome); hormone (corticotropin-releasing).
Biological Functions
The primary function of corticotropin-releasing factor (CRF), a hypothalamic 41-peptide, is the
regulation of the release of adrenocorticotropin hormone (ACTH) from the anterior pituitary
gland, which then stimulates the release of hydrocortisone from the adrenal gland. The human
peptide (hCRF) and the similar sequence found in sheep (oCRF) have been prepared by
synthesis. The ovine form of the hormone, however, has replaced the human form because of its
longer half-life and greater potency; hCRF is no longer commercially available.
Usually, ACTH deficiency in humans is associated with a pituitary disorder rather than with a
deficiency of CRF, and oCRF can be used to distinguish between pituitary hypersecretion of
ACTH (Cushing's disease) and ectopic ACTH secretion, both of which are conditions that cause
a hypersecretion of hydrocortisone. In the case of ectopic ACTH secretion, the administration of
oCRF will elicit little to no response in the production of ACTH and hydrocortisone. Therefore,
synthetic oCRF trifluoroacetate salt is marketed as a diagnostic agent for patients with ACTH dependent Cushing's syndrome.
corticorelin ovine Preparation Products And Raw materials
Raw materials
Preparation Products
corticorelin ovine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 15928 | 58 |
| Cellmano Biotech Limited | 0551-65326643 18156095617 | info@cellmano.com | China | 999 | 58 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696; | info@hanhongsci.com | China | 42982 | 64 |
| Cellmano Biotech Limited | 0551-65326643 18156095617 | info@cellmano.com | China | 1011 | 55 |
| Nanjing Peptide Biotech Ltd. | 025-58361106-805 13082558573 | liugang@njpeptide.com | China | 9961 | 55 |
| Nanjing Meihao Pharmaceutical Technology Co., Ltd. | meitaochem@126.com | meitaochem@126.com | China | 19105 | 58 |
| Gill polypeptide biopharmaceutical (dalian) co., LTD | 021-61263455 13167021076 | amy@glschina.com | China | 8131 | 58 |
| Nanjing Shizhou Biology Technology Co.,Ltd | 13675144456 | alan.chow@synzest.com | China | 9471 | 58 |
| Nanjing Yuanpeptide Biotech Co.，Ltd. | 18168071971 | support@yuan-peptide.com | China | 2977 | 58 |
| Chengdu Jinglin Biotechnology Co., Ltd. | 17711399154 | 3211919385@qq.com | China | 1815 | 58 |
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