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Methyl acetoacetate

Methyl acetoacetate
Methyl acetoacetate structure
CAS No.
105-45-3
Chemical Name:
Methyl acetoacetate
Synonyms
ACM;MAA;Acetoacetic ac;HYL ACETOACETATE;METHYL ACETOACETAT;mthyl acetoacetate;Methyleacetoacetate;METHYL ACETOACETATE;METHYL 3-OXOBUTYRATE;ACETYL METHYL ACETATE
CBNumber:
CB5221273
Molecular Formula:
C5H8O3
Formula Weight:
116.12
MOL File:
105-45-3.mol

Methyl acetoacetate Properties

Melting point:
-28 °C
Boiling point:
169-170 °C70 mm Hg(lit.)
Density 
1.077
vapor pressure 
1 hPa (20 °C)
refractive index 
n20/D 1.419(lit.)
Flash point:
158 °F
storage temp. 
2-8°C
solubility 
460 g/L (20°C)
form 
Liquid
color 
APHA: ≤20
PH
3.8 (863g/l, H2O, 20℃)
explosive limit
1.3-14.2%(V)
Water Solubility 
460 g/L (20 ºC)
Merck 
14,6009
BRN 
506727
CAS DataBase Reference
105-45-3(CAS DataBase Reference)
NIST Chemistry Reference
Butanoic acid, 3-oxo-, methyl ester(105-45-3)
EPA Substance Registry System
Butanoic acid, 3-oxo-, methyl ester(105-45-3)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
  • NFPA
Hazard Codes  Xi
Risk Statements  36
Safety Statements  26
WGK Germany  1
RTECS  AK5775000
Autoignition Temperature 536 °F
TSCA  Yes
HS Code  29183000
Hazardous Substances Data 105-45-3(Hazardous Substances Data)
Toxicity LD50 orally in rats: 3.0 g/kg (Smyth, Carpenter)
Symbol(GHS):
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H227 Combustible liquid Flammable liquids Category 4 Warning P210, P280, P370+P378, P403+P235,P501
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H336 May cause drowsiness or dizziness Specific target organ toxicity,single exposure; Narcotic effects Category 3 Warning P261, P271, P304+P340, P312,P403+P233, P405, P501
H341 Suspected of causing genetic defects Germ cell mutagenicity Category 2 Warning P201,P202, P281, P308+P313, P405,P501
Precautionary statements:
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P337+P313 IF eye irritation persists: Get medical advice/attention.
P370+P378 In case of fire: Use … for extinction.
P405 Store locked up.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P403+P235 Store in a well-ventilated place. Keep cool.
P501 Dispose of contents/container to..…

NFPA 704

Diamond Hazard Value Description
2
0
Health  
Flammability   2 Must be moderately heated or exposed to relatively high ambient temperature before ignition can occur and multiple finely divided suspended solids that do not require heating before ignition can occur. Flash point between 37.8 and 93.3 °C (100 and 200 °F). (e.g. diesel fuel, sulfur)
Instability   0 Normally stable, even under fire exposure conditions, and is not reactive with water (e.g. helium,N2)
Special  

(NFPA, 2010)

Methyl acetoacetate price More Price(13)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 537365 Methyl acetoacetate ReagentPlus , 99% 105-45-3 1kg $40.8 2018-11-13 Buy
Sigma-Aldrich 14610 Methyl acetoacetate analytical standard 105-45-3 5ml-f $53 2018-11-13 Buy
TCI Chemical A0650 Methyl Acetoacetate >99.0%(GC) 105-45-3 25g $12 2018-11-22 Buy
TCI Chemical A0650 Methyl Acetoacetate >99.0%(GC) 105-45-3 500g $23 2018-11-22 Buy
Alfa Aesar A13696 Methyl acetoacetate, 99% 105-45-3 1000g $37.5 2018-11-13 Buy

Methyl acetoacetate Chemical Properties,Uses,Production

Chemical Properties

Colorless, clear liquid

Uses

Methyl acetoacetate (MAA) is a starting material for the syntheses of alpha-substituted aceto- acetic esters and cyclic compounds, e.g. pyrazole, pyrimidine and coumarin derivatives.

Uses

3-Oxobutanoic Acid Methyl Ester is a chemical reagent used in the synthesis of pharmaceuticals. It participates in the Biginelli reaction, forming molecules including dihydropyrimidinones.

General Description

A clear colorless liquid. Flash point 158°F. Denser than water and slightly soluble in water. Vapors heavier than air.

Air & Water Reactions

Very slightly soluble in water.

Reactivity Profile

Methyl acetoacetate is an ester. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides

Hazard

Toxic by ingestion and inhalation.

Health Hazard

May be harmful by inhalation, ingestion, or skin absorption. Causes eye irritation. May cause skin irritation.

Safety Profile

Moderately toxic by ingestion. A skin and severe eye irritant. Combustible when exposed to heat or flame. To fight fire, use foam, CO2, dry chemical. When heated to decomposition it emits acrid smoke and irritating fumes. See also ESTERS.

Methyl acetoacetate Preparation Products And Raw materials

Raw materials

Preparation Products


Methyl acetoacetate Suppliers

Global( 298)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3203 55
Henan DaKen Chemical CO.,LTD.
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Henan Tianfu Chemical Co.,Ltd.
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Mainchem Co., Ltd.
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Haihang Industry Co.,Ltd
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QUALITY CONTROL CHEMICALS INC.
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View Lastest Price from Methyl acetoacetate manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-12-20 Methyl acetoacetate
105-45-3
US $1.00 / kg 1kg 99% 1000kg career henan chemical co

Methyl acetoacetate Spectrum


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