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Methyl acetoacetate

Methyl acetoacetate
Methyl acetoacetate structure
CAS No.
105-45-3
Chemical Name:
Methyl acetoacetate
Synonyms
ACM;MAA;3,6&Acetoacetic ac;HYL ACETOACETATE;METHYL ACETOACETAT;mthyl acetoacetate;Methyleacetoacetate;METHYL ACETOACETATE;METHYL 3-OXOBUTYRATE
CBNumber:
CB5221273
Molecular Formula:
C5H8O3
Formula Weight:
116.12
MOL File:
105-45-3.mol

Methyl acetoacetate Properties

Melting point:
-80 °C (lit.)
Boiling point:
169-170 °C/70 mmHg (lit.)
Density 
1.076 g/mL at 25 °C (lit.)
vapor density 
4 (vs air)
vapor pressure 
1 hPa (20 °C)
refractive index 
n20/D 1.419(lit.)
Flash point:
158 °F
storage temp. 
2-8°C
solubility 
460 g/L (20°C)
pka
10.67±0.46(Predicted)
form 
Liquid
color 
APHA: ≤20
PH
3.8 (863g/l, H2O, 20℃)
explosive limit
1.3-14.2%(V)
Water Solubility 
460 g/L (20 ºC)
Merck 
14,6009
BRN 
506727
InChIKey
WRQNANDWMGAFTP-UHFFFAOYSA-N
CAS DataBase Reference
105-45-3(CAS DataBase Reference)
EWG's Food Scores
1
FDA UNII
CW4I82QAX1
NIST Chemistry Reference
Butanoic acid, 3-oxo-, methyl ester(105-45-3)
EPA Substance Registry System
Methyl acetoacetate (105-45-3)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS08,GHS07
Signal word  Warning
Hazard statements  H227-H336-H341-H319
Precautionary statements  P305+P351+P338-P210e-P280a-P337+P313-P403+P235-P501a-P201-P202-P210-P261-P264-P271-P280-P304+P340+P312-P305+P351+P338+P337+P313-P308+P313-P370+P378-P403+P233-P405-P501
Hazard Codes  Xi
Risk Statements  36
Safety Statements  26
WGK Germany  1
RTECS  AK5775000
Autoignition Temperature 536 °F
TSCA  Yes
HS Code  29183000
Toxicity LD50 orally in rats: 3.0 g/kg (Smyth, Carpenter)
NFPA 704
2
2 0

Methyl acetoacetate price More Price(40)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 8.00107 Methyl acetoacetate for synthesis 105-45-3 100 mL $22.66 2021-12-16 Buy
Sigma-Aldrich 8.00107 Methyl acetoacetate for synthesis 105-45-3 1 L $38.29 2021-12-16 Buy
Sigma-Aldrich 537365 Methyl acetoacetate ReagentPlus , 99% 105-45-3 1kg $43.3 2021-12-16 Buy
Sigma-Aldrich 14610 Methyl acetoacetate analytical standard 105-45-3 5ml-f $56.1 2021-12-16 Buy
Sigma-Aldrich 14610 Methyl acetoacetate analytical standard 105-45-3 5 mL $57.9 2021-12-16 Buy

Methyl acetoacetate Chemical Properties,Uses,Production

Chemical Properties

Colorless, clear liquid

Uses

Methyl acetoacetate (MAA) is a starting material for the syntheses of alpha-substituted aceto- acetic esters and cyclic compounds, e.g. pyrazole, pyrimidine and coumarin derivatives.

Uses

3-Oxobutanoic Acid Methyl Ester is a chemical reagent used in the synthesis of pharmaceuticals. It participates in the Biginelli reaction, forming molecules including dihydropyrimidinones.

Uses

Methyl acetoacetate is used as a chemical reagent used in the synthesis of pharmaceuticals. It participates in the Biginelli reaction, forming molecules including dihydropyrimidinones.Methyl acetoacetate (MAA) is used for the synthesis of alpha-substituted aceto- acetic esters and cyclic compounds, e.g. pyrazole, pyrimidine and coumarin derivatives.

Production Methods

Methyl acetoacetate is produced by a reaction of methyl acetate with sodium methoxide.

General Description

A clear colorless liquid. Flash point 158°F. Denser than water and slightly soluble in water. Vapors heavier than air.

Air & Water Reactions

Very slightly soluble in water.

Reactivity Profile

Methyl acetoacetate is an ester. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides

Hazard

Toxic by ingestion and inhalation.

Health Hazard

May be harmful by inhalation, ingestion, or skin absorption. Causes eye irritation. May cause skin irritation.

Safety Profile

Moderately toxic by ingestion. A skin and severe eye irritant. Combustible when exposed to heat or flame. To fight fire, use foam, CO2, dry chemical. When heated to decomposition it emits acrid smoke and irritating fumes. See also ESTERS.

Carcinogenicity

Not listed by ACGIH, IARC, NTP, or California Proposition 65.

Methyl acetoacetate Preparation Products And Raw materials

Raw materials

Preparation Products


Methyl acetoacetate Suppliers

Global( 448)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-66670886
info@dakenchem.com China 15426 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com China 22607 55
Guangzhou PI PI Biotech Inc
+8618371201331
020-81716319 sales@pipitech.com;87478684@qq.com China 3283 55
Nanjing ChemLin Chemical Industry Co., Ltd.
025-83697070
product@chemlin.com.cn CHINA 3013 60
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418679
86-0551-65418697 info@tnjchem.com China 3000 55
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3623 58
career henan chemical co
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sales@coreychem.com China 29954 58
Hebei Guanlang Biotechnology Co., Ltd.
+8619930503282
sales3@crovellbio.com China 5941 58
Xiamen AmoyChem Co., Ltd
+86 592-605 1114
sales@amoychem.com CHINA 6369 58
Shandong chuangyingchemical Co., Ltd.
18853181302
sale@chuangyingchem.com CHINA 5917 58

View Lastest Price from Methyl acetoacetate manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2022-01-14 Methyl acetoacetate
105-45-3
US $20.00 / Kg/Drum 25Kg/Drum 99.99% 1 ton per week Wuhan Mulei New Material Technology Co. Ltd
2022-01-14 Methyl acetoacetate
105-45-3
US $50.00 / g 1g 99% 200kg/month Wuhan Aoliqisi New Material Technology Co., Ltd.
2021-12-01 Methyl acetoacetate
105-45-3
US $10.50 / KG 1KG 99% 10 ton Hebei Crovell Biotech Co Ltd

Methyl acetoacetate Spectrum


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