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Kaempferol

Pharmacological effects Mechanism of action Bioactivity
Kaempferol
Kaempferol structure
CAS No.
520-18-3
Chemical Name:
Kaempferol
Synonyms
ASARONE;asurone;campherol;c.i.75640;kempferol;kampherol;swartziol;ROBIGENIN;Swartsiol;nimbecetin
CBNumber:
CB5223176
Molecular Formula:
C15H10O6
Formula Weight:
286.24
MOL File:
520-18-3.mol

Kaempferol Properties

Melting point:
276°C
Boiling point:
348.61°C (rough estimate)
Density 
1.2981 (rough estimate)
refractive index 
1.4413 (estimate)
storage temp. 
−20°C
solubility 
ethanol: 20 mg/mL
pka
6.34±0.40(Predicted)
form 
powder
Colour Index 
75640
color 
yellow
Merck 
14,5274
BRN 
304401
Stability:
Unstable in Solution
InChIKey
IYRMWMYZSQPJKC-UHFFFAOYSA-N
CAS DataBase Reference
520-18-3(CAS DataBase Reference)
EWG's Food Scores
1
FDA UNII
731P2LE49E
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS07
Hazard statements  H315-H319-H335
Precautionary statements  P261-P280a-P304+P340-P305+P351+P338-P405-P501a
Hazard Codes  Xi,T
Risk Statements  36/37/38-68-25
Safety Statements  26-36-45-36/37-36/37/38-22
RIDADR  2811
WGK Germany  -
RTECS  LK9275200
8-10-23
HS Code  29329990

Kaempferol price More Price(16)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 00550580 Kaempferol primary reference standard 520-18-3 10mg $55.7 2019-12-02 Buy
Sigma-Aldrich 1354900 Kaempferol United States Pharmacopeia (USP) Reference Standard 520-18-3 15mg $343 2019-12-02 Buy
TCI Chemical K0018 Kaempferol Hydrate >97.0%(HPLC) 520-18-3 1g $875 2019-12-02 Buy
TCI Chemical K0018 Kaempferol Hydrate >97.0%(HPLC) 520-18-3 100mg $155 2019-12-02 Buy
Alfa Aesar J60373 Kaempferol, 98+% 520-18-3 50mg $106 2019-12-02 Buy

Kaempferol Chemical Properties,Uses,Production

Pharmacological effects

Kaempferol (3,5,7‐trihydroxy‐2‐[4‐hydroxyphenyl]‐4H‐1‐benzopyran‐4‐one) is a yellow bioactive flavonoid, which is present inmany edible plants such as tea, cabbage, broccoli, endive, kale, beans, tomato, strawberries, leek, and grapes. It has a significant role in reducing cancer and can act as a therapeutic agent in the treatment of diseases and ailments such as diabetes, obesity, cardiovascular diseases, oxidative stress, asthma, and microbial contamination disorders. Its efficacy, a broad range of activity, and low toxicity compared with other examined compounds, make it an attractive chemical in the fight against diseases (including cancer).

Mechanism of action

Kaempferol acts through different mechanisms: It induces apoptosis (HeLa cervical cancer cells), decreases cell viability (G2/M phase), downregulates phosphoinositide 3‐kinase (PI3K)/AKT (protein kinase B) and human T‐cell leukemia/lymphoma virus‐I (HTLV-I) signaling pathways, suppresses protein expression of epithelial‐mesenchymal transition (EMT)‐related markers including N‐cadherin, E‐cadherin, Slug, and Snail, and metastasis‐related markers such as matrix metallopeptidase 2 (MMP-2).

Bioactivity

As an anti‐oxidant, kaempferol counteracts production of superoxide ions and lowers the formation of reactive oxygen and nitrogen species. It also scavenges Fenton‐generated hydroxyl radical, peroxynitrite, and hydroxyl radicals. Furthermore, kaempferol suppresses the activity of xanthine oxidase and enhances the activities of catalase, heme oxygenase‐1, and superoxide dismutase.

Chemical Properties

Yellow Solid

Uses

antidepressant, inhibits fatty acid amide hydrolase

Biological Activity

Naturally occurring flavonoid found in Gingko biloba and red wines that activates the mitochondrial Ca 2+ uniporter (EC 50 = 7 μ M). Induces caspase-9-mediated apoptosis in a variety of cancer cell lines via downregulation of polo-like kinase 1 (PLK1) expression. Exhibits antioxidant activity and attenuates osteoclastic bone reabsorption in vitro .

Anticancer Research

Kaempferol is one of the secondary metabolites found in some plants, plant-derivedfoods, and traditional medicines. It is a flavonoid compound obtained from someedible plants including grapes, tea, strawberries, broccoli, tomato, cabbage, leek,kale, endive, and beans. It inhibits growth and migration of pancreatic cancer cellsby acting on proto-oncogene tyrosine kinase (Src), ERK1/2, and AKT pathways(Singh et al. 2016a). It is being investigated in pancreatic and lung cancers toevaluate its antiangiogenic, anticancer, and radical scavenging activities. It showsmoderate cytostatic activity in PC3, HeLa, and K562 human cancer cells. It isidentified as aryl hydrocarbon receptor antagonist and acts against ABCG2 (ATP-bindingcassette subfamily G member 2)-mediated multidrug resistance bypreventing the ABCG2 upregulation in esophageal carcinoma. It induces theapoptosis of ovarian cancer cell by activating p53 in intrinsic pathway mechanism.It is an inhibitor of breast cancer resistance protein (BCRP), quinine reductase-2,and a substrate of BCRP (Calderon-Montano et al. 2011; Wang et al. 2012).

Kaempferol Preparation Products And Raw materials

Raw materials

Preparation Products


Kaempferol Suppliers

Global( 341)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shanghai Standard Technology Co., Ltd.
18502101150
+86-21-57127007-6606 ft-sales@nature-standard.com CHINA 1795 58
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
025-85710122 sales@fine-chemtech.com CHINA 890 55
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3623 58
Shaanxi Yikanglong Biotechnology Co., Ltd.
17791478691
yklbiotech@163.com CHINA 297 58
Chengdu Biopurify Phytochemicals Ltd.
18080483897
maggie@biopurify.com CHINA 2645 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28235 58
Accela ChemBio Inc.
(+1)-858-699-3322
(+1)-858-876-1948 info@accelachem.com United States 19819 58
Chongqing Chemdad Co.,Ltd
+86-19923101450
sales@chemdad.com CHINA 4001 58
NanJing Spring & Autumn Biological Engineering CO., LTD.
0086 13770522018
0086-25-83337318 sale03@cqherb.com CHINA 362 58
Hubei xin bonus chemical co. LTD
86-13657291602
027-59338440 linda@hubeijusheng.com CHINA 23047 58

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View Lastest Price from Kaempferol manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-09-18 Kaempferol
520-18-3
US $0.00 / mg 5mg ≥98%(HPLC) 10 g Shanghai Standard Technology Co., Ltd.
2019-09-18 Kaempferol
520-18-3
US $0.00 / mg 5mg Analytical Standard 10 g Shanghai Standard Technology Co., Ltd.
2019-06-25 Kaempferol 520-18-3
520-18-3
US $43.60 / g 10mg ≥98% 100.00 kgs NanJing Spring & Autumn Biological Engineering CO., LTD.

Kaempferol Spectrum


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