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2-AMINO-5-BROMO-4-HYDROXY-6-PHENYLPYRIMIDINE

2-AMINO-5-BROMO-4-HYDROXY-6-PHENYLPYRIMIDINE structure

CAS No.: 56741-95-8

Chemical Name:: 2-AMINO-5-BROMO-4-HYDROXY-6-PHENYLPYRIMIDINE

Synonyms: U-54461;U 54461S;PNU-54461;NSC 149027;bropirimine;Bromopilimine;5-BroMo-6-phenylisocytosine;2-Amino-5-bromo-6-phenylpyrimidin-4-ol;2-AMino-5-broMo-6-phenyl-4-pyriMidinol;2-AMino-5-broMo-6-phenyl-4-pyriMidinone

CBNumber:: CB5225165

Molecular Formula:: C10H8BrN3O

Molecular Weight:: 266.09

MDL Number:: MFCD00813905

MOL File:: 56741-95-8.mol

Last updated:2023-06-30 15:45:59

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2-AMINO-5-BROMO-4-HYDROXY-6-PHENYLPYRIMIDINE Properties

Melting point	285-287° (Stevens); mp 246-248° (Brown, Stevens)
Boiling point	389.7±52.0 °C(Predicted)
Density	1.6292 (rough estimate)
refractive index	1.6520 (estimate)
storage temp.	room temp
solubility	DMSO: ≥5mg/mL (warm DMSO)
form	powder
pka	3.18; 8.53(at 25℃)
color	white to beige
Water Solubility	7.8mg/L(37 ºC)
FDA UNII	J57CTF25XJ

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS08
Signal word	Warning
Hazard statements	H361
Precautionary statements	P281
Hazard Codes	Xn
Risk Statements	63-62
WGK Germany	3
RTECS	UW7351300

2-AMINO-5-BROMO-4-HYDROXY-6-PHENYLPYRIMIDINE price More Price(43)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	SML0218	Bropirimine ≥98% (HPLC)	56741-95-8	10mg	$106	2024-03-01	Buy
Cayman Chemical	29440	Bropirimine	56741-95-8	10mg	$57	2024-03-01	Buy
Cayman Chemical	29440	Bropirimine	56741-95-8	25mg	$116	2024-03-01	Buy
Cayman Chemical	29440	Bropirimine	56741-95-8	5mg	$32	2024-03-01	Buy
Cayman Chemical	29440	Bropirimine	56741-95-8	50mg	$199	2024-03-01	Buy

Product number	Packaging	Price	Buy
SML0218	10mg	$106	Buy
29440	10mg	$57	Buy
29440	25mg	$116	Buy
29440	5mg	$32	Buy
29440	50mg	$199	Buy

2-AMINO-5-BROMO-4-HYDROXY-6-PHENYLPYRIMIDINE Chemical Properties,Uses,Production

Description

Bropirimine is an immunomodulator with diverse biological activities. It is a toll-like receptor 7 (TLR7) agonist that inhibits RANKL-induced osteoclast differentiation of murine bone marrow-derived macrophages (BMDMs) in a concentration-dependent manner, an effect that is reversed by an anti-IFN-β antibody. Dietary administration of bropirimine (200 mg/kg twice per week) prevents development of transitional cell carcinomas (TCCs) in a mouse model of carcinogen-induced bladder carcinoma. Bropirimine (100 mg/kg) reduces pulmonary collagen accumulation and bronchoalveolar lavage fluid (BALF) monocyte and eosinophil infiltration in a hamster model of bleomycin-induced lung fibrosis. It also delays disease onset and progression and increases plasma IFN levels in a mouse model of experimental autoimmune encephalomyelitis (EAE).

Uses

Bropirimine, an immunostimulating agent and toll like receptor (TLR7) agonist, is used in comparison with other TLR7 agonists such as imiquimod, R-848, loxoribine in interferon cell signaling research. Bropirimine may be used in experimental autoimmune encephalomyelitis (EAE) and bladder cancer research.

Uses

Bropirimine is an orally active immunostimulant; anticancer agent. Bropirimine is an interferon inducer that is a potentially useful in the the treatment of superficial bladder cancer (transitional cell carcinoma). Studies suggest that Bropirimine has direct antitumor activity rather than a cytokine-mediated antitumor effect.

Definition

ChEBI: Bropirimine is a member of pyrimidines.

Biochem/physiol Actions

Bropirimine is an immunostimulating agent. The compound induces production of α and β interferons and enhances NK cell function. Bropirimine has antiproliferative effects in cancer cell lines and tumor growth in in vivo models.

storage

Desiccate at RT

2-AMINO-5-BROMO-4-HYDROXY-6-PHENYLPYRIMIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

2-AMINO-5-BROMO-4-HYDROXY-6-PHENYLPYRIMIDINE Suppliers

Global( 85)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63711	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	47465	58
Shaanxi Dideu Medichem Co. Ltd	+86-29-87569266 15319487004	1015@dideu.com	China	2263	58
Career Henan Chemica Co	+86-0371-86658258 15093356674;	laboratory@coreychem.com	China	30255	58
KARMEL TECHNOLOGY (HK) CO.,LIMITED	+8618795957998	karmelhk@126.com	CHINA	2886	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	29474	58
Alfa Chemistry	+1-5166625404	Info@alfa-chemistry.com	United States	21317	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
ZHEJIANG JIUZHOU CHEM CO., LTD	+86-0576225566889 +86-13454675544	admin@jiuzhou-chem.com；jamie@jiuzhou-chem.com；alice@jiuzhou-chem.com	China	20000	58

Supplier	Advantage
BOC Sciences	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
Shaanxi Dideu Medichem Co. Ltd	58
Career Henan Chemica Co	58
KARMEL TECHNOLOGY (HK) CO.,LIMITED	58
Dideu Industries Group Limited	58
Alfa Chemistry	58
TargetMol Chemicals Inc.	58
ZHEJIANG JIUZHOU CHEM CO., LTD	58

View Lastest Price from 2-AMINO-5-BROMO-4-HYDROXY-6-PHENYLPYRIMIDINE manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2021-07-02	2-AMINO-5-BROMO-4-HYDROXY-6-PHENYLPYRIMIDINE USP/EP/BP 56741-95-8	US $1.10 / g	1g	99.9%	100 Tons Min	Dideu Industries Group Limited
	2020-05-03	Bropirimine 56741-95-8	US $0.00-0.00 / Kg	1KG	99.0%	800 ton	Shaanxi Dideu Medichem Co. Ltd

2-AMINO-5-BROMO-4-HYDROXY-6-PHENYLPYRIMIDINE USP/EP/BP
56741-95-8
US $1.10 / g
99.9%
Dideu Industries Group Limited

Bropirimine
56741-95-8
US $0.00-0.00 / Kg
99.0%
Shaanxi Dideu Medichem Co. Ltd

56741-95-8(2-AMINO-5-BROMO-4-HYDROXY-6-PHENYLPYRIMIDINE)Related Search:

Bromisoval Neostigmine bromide Mestinon 2-Amino-4-hydroxy-6-phenylpyrimidine 2-AMINO-5-BROMO-4-HYDROXY-6-PHENYLPYRIMIDINE

2-Amino-5-bromopyrimidine 5-BROMO-6-METHYLPYRIMIDIN-4-OL 5-Bromo-4-phenylpyrimidine 2-Amino-4-methyl-5-bromopyrimidine 5-bromo-1H-pyrimidin-4-one

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1of3

2-Amino-5-bromo-6-phenylpyrimidin-4(3H)-one 2-AMINO-4-HYDROXY-5-BROMO-6-PHENYLPYRIMIDINE 2-AMINO-5-BROMO-4-HYDROXY-6-PHENYLPYRIMIDINE 2-Amino-5-bromo-6-phenylpyrimidin-4-ol 2-Amino-5-bromo-6-phenylpyrimidin-4(1H)-one 5-Bromo-6-phenyl-2,3-dihydro-2-iminopyrimidin-4(1H)-one PNU-54461 U-54461 2-AMino-5-broMo-6-phenyl-4(3H)-pyriMidinone 2-AMino-5-broMo-6-phenyl-4-pyriMidinol 2-AMino-5-broMo-6-phenyl-4-pyriMidinone 5-BroMo-2,3-dihydro-2-iMino-6-phenyl-4(1H)-pyriMidinone 5-BroMo-6-phenylisocytosine NSC 149027 4(3H)-PyriMidinone, 2-aMino-5-broMo-6-phenyl- 2-Amino-5-bromo-4-phenyl-6-hydroxypyrimidine U 54461S 2-amino-5-bromo-6-phenyl-4(1h)-pyrimidinon 2-amino-5-bromo-6-phenyl-4(1h)-pyrimidinone bropirimine 2-Amino-5-bromo-6-phenyl-4(3H)-pyrimidone 2-amino-5-bromo-6-phenyl-1H-pyrimidin-4-one 2-AMINO-5-BROMO-4-HYDROXY-6-PHENYLPYRIMIDINE USP/EP/BP carcinoma,antitumour,Bropirimine,tract,immunostimulant,Inhibitor,differentiation,Toll-like Receptor (TLR),urinary,inhibit Bromopilimine 56741-95-8 C10H8BrN3O Heterocycle-Pyrimidine series Aromatics Heterocycles Intermediates & Fine Chemicals Pharmaceuticals