SPLITOMICIN
- CAS No.
- 5690-03-9
- Chemical Name:
- SPLITOMICIN
- Synonyms
- Spitomicin;Splitomycin;SPLITOMICIN;Splitomicin >1H-Benzo[f]chromen-3(2H)-one;1,2-Dihydro-3H-benzo[f]chromen-3-one;1,2-DIHYDRO-3H-NAPHTHO[2,1-B]PYRAN-3-ONE;2-Hydroxy-1-naphthalenepropanoic acid delta-lactone;Inhibitor,Histone deacetylases,Splitomycin,HDAC,inhibit,Splitomicin
- CBNumber:
- CB5227437
- Molecular Formula:
- C13H10O2
- Molecular Weight:
- 198.22
- MDL Number:
- MFCD08705254
- MOL File:
- 5690-03-9.mol
- MSDS File:
- SDS
| Melting point | 73-74.5℃ |
|---|---|
| storage temp. | 2-8°C |
| solubility | insoluble in H2O; ≥44.2 mg/mL in EtOH with ultrasonic; ≥9.05 mg/mL in DMSO |
| form | solid |
| color | White to Almost white |
| FDA UNII | R1JT1VV9Z3 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501 |
| WGK Germany | 3 |
| HS Code | 2932.20.4500 |
SPLITOMICIN price More Price(32)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | S4068 | Splitomicin ≥98% (HPLC), powder | 5690-03-9 | 5mg | $55.62 | 2024-03-01 | Buy |
| Sigma-Aldrich | 567750 | Splitomicin - CAS 5690-03-9 - Calbiochem A cell-permeable lactone derived from β-naphthol that acts as a selective inhibitor of NAD+-dependent histone deacetylase activity of Sir2 protein (IC?? = 60 μM). | 5690-03-9 | 5MG | $201 | 2024-03-01 | Buy |
| TCI Chemical | S0892 | Splitomicin >98.0%(GC) | 5690-03-9 | 1g | $424 | 2024-03-01 | Buy |
| TCI Chemical | S0892 | Splitomicin >98.0%(GC) | 5690-03-9 | 200mg | $142 | 2024-03-01 | Buy |
| Cayman Chemical | 13168 | Splitomicin ≥98% | 5690-03-9 | 1mg | $32 | 2024-03-01 | Buy |
SPLITOMICIN Chemical Properties,Uses,Production
Uses
Splitomicin is a selective and potent inhibitor of Sir2 (silent information regulator 2), producing an inhibitory effect on neutrophils. Acts as an anti-inflammatory agent.
Definition
ChEBI: A benzochromenone that is 2,3-dihydro-1H-benzo[f]chromene substituted by an oxo group at position 3. It has been found to exhibit potential inhibitory activity against Sir2 proteins.
Synthesis Reference(s)
Journal of the American Chemical Society, 69, p. 2341, 1947 DOI: 10.1021/ja01202a027
General Description
A cell-permeable and selective inhibitor of NAD+-dependent deacetylase activity of Sir2 protein (IC50 = 60 μM). Creates a phenocopy of the sir2 deletion mutant in S. cerevisiae and sensitizes mammalian cells to a variety of DNA-damaging agents by abrogating Sir2p activity on p53. Reported to act by either altering or blocking access to the acetylated histone-binding pocket.
Biological Activity
Inhibitor of Sir2p (IC 50 = 60 μ M), an NAD + -dependent Sir2 family deacetylase required for chromatin-dependent silencing in yeast.
Biochem/physiol Actions
Cell permeable: yes
storage
+4°C
SPLITOMICIN Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24539 | 81 |