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Alpidem

Alpidem Structure
Alpidem structure
CAS No.
82626-01-5
Chemical Name:
Alpidem
Synonyms
ALPIDEM;IMidazo;inanxyl;Ananxyl;Alpidemum;SL-80．0342;SL 80.0342-00;Unii-I93sc245qz;Alpidemum [latin];ALPIDEM USP/EP/BP
CBNumber:
CB5241330
Molecular Formula:
C21H23Cl2N3O
Molecular Weight:
404.33
MDL Number:
MFCD00866978
MOL File:
82626-01-5.mol
Last updated:2023-09-04 15:51:00
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Alpidem Properties

Melting point 136-138°C
Density 1.24±0.1 g/cm3(Predicted)
storage temp. Refrigerator
solubility DMSO: ≥10mg/mL
pka 4.74±0.50(Predicted)
form powder
color white to tan
FDA UNII I93SC245QZ

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P280-P305+P351+P338
NFPA 704
0
2 0

Alpidem price More Price(16)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich A1862 Alpidem ≥98% (HPLC), powder 82626-01-5 25mg $522 2021-12-16 Buy
Sigma-Aldrich A1862 Alpidem ≥98% (HPLC), powder 82626-01-5 5mg $135 2021-12-16 Buy
TRC A575560 Alpidem 82626-01-5 100mg $1590 2021-12-16 Buy
TRC A575560 Alpidem 82626-01-5 500mg $4915 2021-12-16 Buy
Biosynth Carbosynth FA17325 Alpidem 82626-01-5 10mg $368 2021-12-16 Buy
Product number Packaging Price Buy
A1862 25mg $522 Buy
A1862 5mg $135 Buy
A575560 100mg $1590 Buy
A575560 500mg $4915 Buy
FA17325 10mg $368 Buy

Alpidem Chemical Properties,Uses,Production

Description

Alpidem is an imidazopyridine antianxiety agent with anticonvulsant properties. It is claimed to be the first non-benzodiazepine anxiolytic to show selectivity for the omega-1 modulatory site of the GABA, receptors. Alpidem is reported to be superior to buspirone and similar to the benzodiazepines, but is significantly better tolerated with lower abuse potential.

Chemical Properties

White to Off-White Solid

Originator

Synthelabo (France)

Uses

A peripheral benzodiazepine GABAA receptor ligand, a new anxiolytic

Definition

ChEBI: Alpidem is a member of imidazoles.

brand name

Ananxyl

Biochem/physiol Actions

Alpidem is a potent antagonist of peripheral benzodiazepine receptor (PBR) that is located on the outer mitochondrial membrane and interacts with the mitochondrial permeability transition (MPT) pore. Alpidem is an anxiolytic drug from the imidazopyridine family. Alpidem acts selectively on the α3 receptor subtype and to a lesser extent at the α1 subtype (Kd of 0.33nM and 1.67nM respectively), of the benzodiazepine receptor.

Clinical claims and research

Alpidem is an imidazopyridine partial agonist that also shows relative selectivity for the type I benzodiazepine receptor. Studies have shown an anxiolytic effect comparable with the classic benzodiazepines, but with an improved adverse effect profile (Pancheri et al. 1993). It has also been compared with buspirone in patients with generalized anxiety disorder and shown to be more rapidly effective and again to have a more favorable adverse effect profile (Legris et al. 1993). Longer-term studies with alpidem have shown that tolerance does not occur, and no significant problems of withdrawal on discontinuation were found (Chevalier et al. 1993). Alpidem was licensed in France for the treatment of anxiety but has now been suspended because of recent reports of alpidem-induced hepatic dysfunction. The reason for this is unclear, but it may be a reflection of the fact that alpidem also binds to peripheral benzodiazepine receptors, which are present in high density in the liver.

Alpidem Preparation Products And Raw materials

Raw materials

Oxalyl chloride

Preparation Products

Alpidem Suppliers

Global( 52)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1026@dideu.com China 29220 58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		+86-057181025280; +8617767106207 sales@molcore.com China 49739 58
Henan Aochuang Chemical Co.,Ltd. 		+86-0371-63689365 +8618638391208 sales@aochuangchem.com China 9425 58
Amadis Chemical Company Limited 		571-89925085 sales@amadischem.com China 131981 58
J & K SCIENTIFIC LTD. 010-82848833 400-666-7788 jkinfo@jkchemical.com China 96815 76
LGM Pharma 1-(800)-881-8210 inquiries@lgmpharma.com United States 2127 70
Chemsky（shanghai）International Co.,Ltd. 021-50135380 shchemsky@sina.com China 32344 50
Hangzhou J&H Chemical Co., Ltd. +86-571-87396432 sales@jhechem.com China 10015 53
Chengdu Dianchun Technology Co., Ltd 400-1166-196 18502815961 cdhxsj@163.com China 14623 60
Supplier Advantage
TargetMol Chemicals Inc. 		58
Dideu Industries Group Limited 		58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		58
Henan Aochuang Chemical Co.,Ltd. 		58
Amadis Chemical Company Limited 		58
J & K SCIENTIFIC LTD. 76
LGM Pharma 70
Chemsky（shanghai）International Co.,Ltd. 50
Hangzhou J&H Chemical Co., Ltd. 53
Chengdu Dianchun Technology Co., Ltd 60

View Lastest Price from Alpidem manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Alpidem pictures 2022-10-15 Alpidem
82626-01-5
 US $0.00-0.00 / kg 1kg 98% 1Ton Henan Aochuang Chemical Co.,Ltd.
ALPIDEM USP/EP/BP pictures 2021-07-23 ALPIDEM USP/EP/BP
82626-01-5
 US $1.10 / g 1g 99.9% 100 Tons min Dideu Industries Group Limited
  • Alpidem pictures
  • Alpidem
    82626-01-5
  • US $0.00-0.00 / kg
  • 98%
  • Henan Aochuang Chemical Co.,Ltd.

Alpidem Spectrum

Alpidem(82626-01-5)1HNMR

82626-01-5(Alpidem)Related Search:

Piracetam Alpidem 2-IMIDAZO[1,2-A]PYRIDIN-3-YLACETAMIDE 4-(4-CHLORO-PHENYL)-5-METHYL-1H-IMIDAZOLE (1H-IMIDAZOL-4-YL)-ACETALDEHYDE
N-METHYL-1H-IMIDAZOLE-4-ETHANAMINE DIHYDROCHLORIDE 6-CHLORO-2-PHENYL-IMIDAZO[1,2-A]PYRIDINE 2-(2-PHENYL-IMIDAZO[1,2-A]PYRIDIN-3-YL)-ETHYLAMINE Imidazo[1,2-a]pyridine-3-ethanamine (9CI) 2-(4-CHLORO-PHENYL)-IMIDAZO[1,2-A]PYRIDINE
4-Methylhistamine dihydrochloride 6-Chloroimidazo[1,2-a]pyridine, HCl 3-METHYLHISTAMINE DIHYDROCHLORIDE Alpidem-d14 4-methylhistamine
N,N-dimethylhistamine Imidazo(1,2-a)pyridine-3-acetamide,2-methyl-

1of4

ALPIDEM 6-Chloro-2-(p-chlorophenyl)-N,N-dipropylimidazo(1,2-a)pyridine-3-aceta mide 6-Chloro-2-(4-chlorophenyl)-N,N-dipropyl-imidazo[1,2-α]pyridine-3-acetamide SL 80.0342-00 6-Chloro-2-(4-chlorophenyl)-N,N-dipropyl-imidazo[1,2-a]pyridine-3-acetamide 6-Chlor-2-(4-chlorphenyl)-N,N-dipropylimidazol(1,2-A)pyridin-3-acetamid Alpidemum Alpidemum [latin] Imidazo(1,2-A)pyridine-3-acetamide, 6-chloro-2-(4-chlorophenyl)-N,N-dipropyl- Unii-I93sc245qz 2-(6-Chloro-2-(4-chlorophenyl)iMidazo[1,2-a]pyridin-3-yl)-N,N-dipropylacetaMide IMidazo inanxyl SL-80．0342 Ananxyl 6-Chloro-2-(4-chlorophenyl)-N，N-dipmpylimidazol[1，2-α]pyridine-3-acetamide ALPIDEM USP/EP/BP inhibit,GABA Receptor,Gamma-aminobutyric acid Receptor,Inhibitor,Alpidem,γ-Aminobutyric acid Receptor 82626-01-5 C21H23Cl2N3O Pharmaceuticals Aromatics Compounds Aromatics Heterocycles Intermediates & Fine Chemicals