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Rifaximin

Rifaximin
Rifaximin structure
CAS No.
80621-81-4
Chemical Name:
Rifaximin
Synonyms
l105;normix;l105sv;XIFAXAN;RIFACOL;RIFAXIMIN;rifaxidin;RIFAMIXIN;28e))-27r;Rifaximinn
CBNumber:
CB5244184
Molecular Formula:
C43H51N3O11
Formula Weight:
785.88
MOL File:
80621-81-4.mol

Rifaximin Properties

Melting point:
200-2050C (dec)
Density 
1.36±0.1 g/cm3(Predicted)
storage temp. 
0-6°C
solubility 
ethanol: soluble1mg/mL
form 
powder
pka
2.83±0.70(Predicted)
color 
dark orange
Merck 
14,8220
InChIKey
NZCRJKRKKOLAOJ-XRCRFVBUSA-N
FDA UNII
L36O5T016N
SAFETY
  • Risk and Safety Statements
WGK Germany  2
RTECS  KD1576000
Toxicity LD50 orally in rats: >2000 mg/kg (Borelli, Bertoli)

Rifaximin price More Price(11)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 33999 Rifaximin VETRANAL 80621-81-4 100mg-r $88.9 2019-12-02 Buy
Sigma-Aldrich R9904 Rifaximin 80621-81-4 1g $119 2019-12-02 Buy
TCI Chemical R0101 Rifaximin >97.0%(HPLC)(N) 80621-81-4 1g $113 2020-06-24 Buy
TCI Chemical R0101 Rifaximin >97.0%(HPLC)(N) 80621-81-4 5g $407 2020-06-24 Buy
Cayman Chemical 16131 Rifaximin ≥98% 80621-81-4 5g $350 2020-06-24 Buy

Rifaximin Chemical Properties,Uses,Production

Description

Rifaximin is an antibiotic structurally related to rifamycin. It is reported to be efficacious in the treatment of gastrointestinal infections and hepatic encephalopathy, being highly active against Gram-positive and -negative aerobic and anaerobic bacteria. Due to poor systemic absorption, rifaximin is effective in presurgical sterilization of the GI tract.It displays good activity against a wide spectrum of bacteria, including Salmonella spp., S. aureus, and E. coli.

Chemical Properties

Red-Orange Crystalline Powder

Originator

Alfa (Italy)

Uses

antibacterial, RNA synthesis inhibitor

Uses

Muscle Relaxant

Uses

Non-absorbable semisynthetic Rifamycin antibiotic

Definition

ChEBI: A semisynthetic member of the class of rifamycins and non-systemic gastrointestinal site-specific broad spectrum antibiotic. Used in the treatment of traveller's diarrhoea, hepatic encephalopathy and irritable bowel syndrome.

brand name

Xifaxan (Salix);Normix.

Antimicrobial activity

The in-vitro activity is slightly inferior to that of rifampicin. The MIC90 for Gram-positive cocci is well below 1 mg/L, with the exception of enterococci (MIC 2–8 mg/L). Among intestinal pathogens C. difficile is sensitive (MIC90 0.8 mg/L), Esch. coli, Salmonella spp. and Shigella spp. are inhibited by 4–8 mg/L. Campylobacter jejuni is mostly insensitive.

Pharmaceutical Applications

A semisynthetic derivative of rifamycin S formulated for oral administration. It is poorly absorbed from the gastrointestinal tract, where its high concentrations are effective against a variety of gastrointestinal pathogens.

Pharmacokinetics

Oral absorption is very low. However, a fraction of the dose may be absorbed and rapidly eliminated through the bile. A 400 mg oral dose produces a maximum plasma concentration of 3.8 mg/L after 1.2 h. The plasma half-life is 5.8 h. Up to 90% of the administered dose is concentrated in the gut, less than 0.2% in the liver and kidney, and less than 0.01% in other tissues.

Clinical Use

It is used for a variety of gastrointestinal diseases, including the treatment of traveler’s diarrhea. Preliminary results suggest clinical efficacy in the therapy of hepatic encephalopathy and of C. difficile infections.

Side effects

Oral doses up to 100 mg/kg for 6 months produced no significant signs of toxicity to rats. Teratogenic effects in rats and rabbits have been reported (pregnancy category C).
Very few adverse effects were reported during human treatment, mostly gastrointestinal discomfort. Prolonged therapy was associated with infrequent urticarial skin reactions.

Rifaximin Preparation Products And Raw materials

Raw materials

Preparation Products


Rifaximin Suppliers

Global( 252)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22626 55
PI & PI BIOTECH INC.
18371201331
020-81716319 Sales@pipitech.com CHINA 3050 55
Hubei XinRunde Chemical Co., Ltd.
+8615102730682
02783214688 bruce@xrdchem.cn CHINA 568 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30045 58
GIHI CHEMICALS CO.,LIMITED
08657186217390
sales@gihichemicals.com CHINA 309 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28234 58
Casorganics US Corp
+17326109938
sales@casorganics.com CHINA 175 58
Xiamen AmoyChem Co., Ltd
+86 592-605 1114
sales@amoychem.com CHINA 6371 58
Hubei xin bonus chemical co. LTD
86-13657291602
027-59338440 linda@hubeijusheng.com CHINA 23045 58
BOC Sciences
1-631-619-7922
1-631-614-7828 inquiry@bocsci.com United States 20039 58

View Lastest Price from Rifaximin manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2020-05-07 Rifaximin
80621-81-4
US $1.00-1.00 / KG 1g 99% 50tons Shaanxi Dideu Medichem Co. Ltd
2019-12-27 Rifaximin
80621-81-4
US $1.00-0.00 / KG 1KG 99%+ 10000KG Shaanxi Dideu Medichem Co. Ltd
2018-08-20 Rifaximin
80621-81-4
US $1.00 / KG 1KG 98% 100KG career henan chemical co

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