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2-AMINO-BETA-NAPHTHOTHIAZOLE

CAS No.
40172-65-4
Chemical Name:
2-AMINO-BETA-NAPHTHOTHIAZOLE
Synonyms
SKA 31;-2-amine;AKOS BBS-00006561;IFLAB-BB F1386-0401;naphtho[1,2-d]thiazoL;LABOTEST-BB LT00154570;2-Amino-β-naphthothiazole;2-AMINONAPHTHO-1,2-THIAZOLE;2-AMINO-BETA-NAPHTHOTHIAZOLE;naphtho[1,2-d]thiazol-2-amine
CBNumber:
CB5244427
Molecular Formula:
C11H8N2S
Molecular Weight:
200.26
MDL Number:
MFCD00051329
MOL File:
40172-65-4.mol
MSDS File:
SDS
Last updated:2023-09-20 16:43:00

2-AMINO-BETA-NAPHTHOTHIAZOLE Properties

Melting point 184-188°C
Boiling point 417.1±28.0 °C(Predicted)
Density 1.403±0.06 g/cm3(Predicted)
storage temp. Keep in dark place,Sealed in dry,2-8°C
solubility DMSO: ≥30mg/mL
form solid
pka 3.50±0.30(Predicted)
color Off-white
Stability Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
CAS DataBase Reference 40172-65-4(CAS DataBase Reference)
FDA UNII SW12CAS9T7
EPA Substance Registry System Naphtho[1,2-d]thiazol-2-amine (40172-65-4)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H319
Precautionary statements  P264-P270-P280-P301+P312-P305+P351+P338-P337+P313
Hazard Codes  Xn
Risk Statements  20/21/22-36/37/38-36-22
Safety Statements  22-36/37/39-26
NFPA 704
0
2 0

2-AMINO-BETA-NAPHTHOTHIAZOLE price More Price(23)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich S5576 SKA-31 ≥98% (HPLC) 40172-65-4 5mg $130 2024-03-01 Buy
Sigma-Aldrich S5576 SKA-31 ≥98% (HPLC) 40172-65-4 25mg $721 2024-03-01 Buy
Cayman Chemical 29690 SKA-31 40172-65-4 5mg $53 2024-03-01 Buy
Cayman Chemical 29690 SKA-31 40172-65-4 10mg $92 2024-03-01 Buy
Cayman Chemical 29690 SKA-31 40172-65-4 25mg $213 2024-03-01 Buy
Product number Packaging Price Buy
S5576 5mg $130 Buy
S5576 25mg $721 Buy
29690 5mg $53 Buy
29690 10mg $92 Buy
29690 25mg $213 Buy

2-AMINO-BETA-NAPHTHOTHIAZOLE Chemical Properties,Uses,Production

Description

SKA-31 (40172-65-4) is a KCa3.1 and KCa2 potassium channel activator (EC50 =260, 2900, 2900 nM for KCa3.1, KCa2.1 and KCa2.2 respectively). Enhanced acetylcholine-induced EDHF dilator response in mouse carotid arteries and lowers blood pressure in mouse models at 30 mg/Kg.1,2 Evokes robust vasodilation in rat mesenteric arteries.3

Biological Activity

Activator of K Ca 3.1 and K Ca 2 channels (EC 50 values are 260, 2900, 2900 nM for K Ca 3.1, K Ca 2.1 and K Ca 2.2 respectively). Potentiates acetylcholine-induced EDHF-type dilations of mouse carotid arteries and lowers blood pressure in normotensive and hypertensive mice.

storage

+4°C

References

Sankaranaravanan et al. (2009), Naphtho[1,2-d]thiazol-2-ylamine (SKA-31), a new activator of KCa2 and KCa3.1 potassium channels, potentiates the endothelium-derived hyperpolarizing factor response and lowers blood pressure; Mol. Pharmacol., 75 281 Brahler et al. (2009), Genetic deficit of SK3 and IK1 channels disrupts the endothelium-derived hyperpolarizing factor vasodilator and causes hypertension ; Circulation, 119 2323 Khaddaj-Mallat al. (2018), SKA-31, an activator of endothelial Ca2+-activated K+ channels evokes robust vasodilation in rat mesenteric arteries; Eur. J. Pharmacol., 831 60

333-20-0
134-32-7
40172-65-4
Synthesis of 2-AMINO-BETA-NAPHTHOTHIAZOLE from Potassium thiocyanate and 1-Naphthylamine

2-AMINO-BETA-NAPHTHOTHIAZOLE Suppliers

Global( 86)Suppliers
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ATK CHEMICAL COMPANY LIMITED
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ORGANICA Feinchemie GmbH +49 3494636389 info@organica.de Germany 598 65
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3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037 3bsc@sina.com China 15848 69
NAPHTHO[1,2-D][1,3]THIAZOL-2-AMINE NAPHTHO[1,2-D]THIAZOL-2-YLAMINE 2-AMINO-BETA-NAPHTHOTHIAZOLE 2-AMINO-NAPHTHO[1,2-D]THIAZOLE 2-AMINONAPHTHO-1,2-THIAZOLE AKOS BBS-00006561 IFLAB-BB F1386-0401 LABOTEST-BB LT00154570 naphtho[1,2-d]thiazol-2-amine Naphtho[1,2-d]thiazol-2-amine (9CI) 2-Amino-β-naphthothiazole SKA 31 2-(2-amino-5,6-dihydro-4H-pyrimidin-1-yl)acetic acid -2-amine naphtho[1,2-d]thiazoL Naphtho[1,2-d]thiazol-2(1H)-imine benzo[e][1,3]benzothiazol-2-amine inhibit,Potassium Channel,SKA-31,KcsA,Inhibitor 40172-65-4 BENZOTHIAZOLE