ChemicalBook >> CAS DataBase List >>ARZOXIFENE

ARZOXIFENE

CAS No.
182133-25-1
Chemical Name:
ARZOXIFENE
Synonyms
SERMIII;ARZOXIFENE;2-(4-methoxyphenyl)-3-[4-(2-piperidin-1-ylethoxy)phenoxy]-1-benzothiophen-6-ol;2-(4-Methoxyphenyl)-3-[4-[2-(1-piperidinyl)ethoxy]phenoxy]benzo[b]thiophene-6-ol;Benzo[b]thiophene-6-ol, 2-(4-Methoxyphenyl)-3-[4-[2-(1-piperidinyl)ethoxy]phenoxy]-;3-[(4-{[2-(hexahydropyridin-1-yl)ethyl]oxy}phenyl)oxy]-2-(4-methoxyphenyl)benzo[b]thiophen-6-ol
CBNumber:
CB52451290
Molecular Formula:
C28H29NO4S
Molecular Weight:
475.6
MDL Number:
MFCD09837789
MOL File:
182133-25-1.mol
MSDS File:
SDS
Last updated:2022-12-21 16:56:50

ARZOXIFENE Properties

Melting point 174-176°
Boiling point 656.4±55.0 °C(Predicted)
Density 1.234
pka 9.20±0.40(Predicted)
FDA UNII E569WG6E60

ARZOXIFENE price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC A779700 Arzoxifene 182133-25-1 0.5mg $195 2021-12-16 Buy
American Custom Chemicals Corporation API0005130 ARZOXIFENE 95.00% 182133-25-1 5MG $504.41 2021-12-16 Buy
Product number Packaging Price Buy
A779700 0.5mg $195 Buy
API0005130 5MG $504.41 Buy

ARZOXIFENE Chemical Properties,Uses,Production

Uses

Arzoxifene is a selective estrogen receptor modulator. It is a potent estrogen antagonist in mammary and uterine tissue while acting as an estrogen agonist to maintain bone density and lower serum cholesterol.

Clinical Use

Arzoxifene is a third-generation SERM currently in Phase III clinical trials for the treatm ent of ER-positive recurrent/metastatic breast cancer. Similar to raloxifene, it is an ER antagonist in both breast and uterine tissues and an ER agonist on bone and the cardiovascular system. Arzoxifene is able to both preserve and build bone mineral density, which makes it a viable candidate for the treatment of osteoporosis. Ample evidence from early clinical trials indicates that arzoxifene also can be utilized as a chemopreventive agent against breast cancer.

Side effects

Adverse effects include hot flashes (major) and headache, nausea, vomiting, and constipation (minor).

ARZOXIFENE Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 21)Suppliers
Supplier Tel Email Country ProdList Advantage
Hubei Jusheng Technology Co.,Ltd.
18871490254 linda@hubeijusheng.com CHINA 28180 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427 sales@conier.com China 49392 58
Hangzhou MolCore BioPharmatech Co.,Ltd.
+86-057181025280; +8617767106207 sales@molcore.com China 49739 58
J & K SCIENTIFIC LTD. 010-82848833 400-666-7788 jkinfo@jkchemical.com China 96815 76
Hangzhou Sage Chemical Co., Ltd. +86057186818502 13588463833 info@sagechem.com China 10269 58
Beijing Yisiyan Technology Research Center 010-56645598 13366904824 bjkaida@163.com China 1613 59
Beijing HuaMeiHuLiBiological Chemical 010-56205725 waley188@sohu.com China 12338 58
Shenzhen Polymeri Biochemical Technology Co., Ltd. +86-400-002-6226 sales@rrkchem.com China 56086 58
Beijing Fuchen Technology Co., Ltd 15652759959 623245911@qq.com China 462 58
Changzhou Bojia Biomedical Technology Co., Ltd. 2122619822 czbjpharma@126.com China 18488 58
ARZOXIFENE 2-(4-Methoxyphenyl)-3-[4-[2-(1-piperidinyl)ethoxy]phenoxy]benzo[b]thiophene-6-ol Benzo[b]thiophene-6-ol, 2-(4-Methoxyphenyl)-3-[4-[2-(1-piperidinyl)ethoxy]phenoxy]- 2-(4-methoxyphenyl)-3-[4-(2-piperidin-1-ylethoxy)phenoxy]-1-benzothiophen-6-ol 3-[(4-{[2-(hexahydropyridin-1-yl)ethyl]oxy}phenyl)oxy]-2-(4-methoxyphenyl)benzo[b]thiophen-6-ol SERMIII 182133-25-1