ARZOXIFENE
- CAS No.
- 182133-25-1
- Chemical Name:
- ARZOXIFENE
- Synonyms
- SERMIII;ARZOXIFENE;2-(4-methoxyphenyl)-3-[4-(2-piperidin-1-ylethoxy)phenoxy]-1-benzothiophen-6-ol;2-(4-Methoxyphenyl)-3-[4-[2-(1-piperidinyl)ethoxy]phenoxy]benzo[b]thiophene-6-ol;Benzo[b]thiophene-6-ol, 2-(4-Methoxyphenyl)-3-[4-[2-(1-piperidinyl)ethoxy]phenoxy]-;3-[(4-{[2-(hexahydropyridin-1-yl)ethyl]oxy}phenyl)oxy]-2-(4-methoxyphenyl)benzo[b]thiophen-6-ol
- CBNumber:
- CB52451290
- Molecular Formula:
- C28H29NO4S
- Molecular Weight:
- 475.6
- MDL Number:
- MFCD09837789
- MOL File:
- 182133-25-1.mol
- MSDS File:
- SDS
| Melting point | 174-176° |
|---|---|
| Boiling point | 656.4±55.0 °C(Predicted) |
| Density | 1.234 |
| pka | 9.20±0.40(Predicted) |
| FDA UNII | E569WG6E60 |
ARZOXIFENE price More Price(2)
ARZOXIFENE Chemical Properties,Uses,Production
Uses
Arzoxifene is a selective estrogen receptor modulator. It is a potent estrogen antagonist in mammary and uterine tissue while acting as an estrogen agonist to maintain bone density and lower serum cholesterol.
Clinical Use
Arzoxifene is a third-generation SERM currently in Phase III clinical trials for the treatm ent of ER-positive recurrent/metastatic breast cancer. Similar to raloxifene, it is an ER antagonist in both breast and uterine tissues and an ER agonist on bone and the cardiovascular system. Arzoxifene is able to both preserve and build bone mineral density, which makes it a viable candidate for the treatment of osteoporosis. Ample evidence from early clinical trials indicates that arzoxifene also can be utilized as a chemopreventive agent against breast cancer.
Side effects
Adverse effects include hot flashes (major) and headache, nausea, vomiting, and constipation (minor).
ARZOXIFENE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49392 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Hangzhou Sage Chemical Co., Ltd. | +86057186818502 13588463833 | info@sagechem.com | China | 10269 | 58 |
| Beijing Yisiyan Technology Research Center | 010-56645598 13366904824 | bjkaida@163.com | China | 1613 | 59 |
| Beijing HuaMeiHuLiBiological Chemical | 010-56205725 | waley188@sohu.com | China | 12338 | 58 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 | sales@rrkchem.com | China | 56086 | 58 |
| Beijing Fuchen Technology Co., Ltd | 15652759959 | 623245911@qq.com | China | 462 | 58 |
| Changzhou Bojia Biomedical Technology Co., Ltd. | 2122619822 | czbjpharma@126.com | China | 18488 | 58 |