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Olodaterol

Olodaterol structure

CAS No.: 868049-49-4

Chemical Name:: Olodaterol

Synonyms: Olodaterol free base;BI-1744;Striverdi;Olodaterol;OLODATEROL D3;BI 1744(Olodaterol;Striverdi Respimat);Olodaterol USP/EP/BP;Olodaterol ImpurityＡ　;Olodaterol Discontinued

CBNumber:: CB52484977

Molecular Formula:: C21H26N2O5

Molecular Weight:: 386.44

MDL Number:: MFCD16619349

MOL File:: 868049-49-4.mol

MSDS File:: SDS

Last updated:2023-09-06 17:45:48

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Olodaterol Properties

Boiling point	649.0±55.0 °C(Predicted)
Density	1.250
solubility	DMF: 20 mg/ml; DMF:PBS (pH 7.2) (1:3): 0.25 mg/ml; DMSO: 15 mg/ml; Ethanol: 1 mg/ml
form	A crystalline solid
pka	9.42±0.20(Predicted)
Stability	Hygroscopic
FDA UNII	VD2YSN1AFD
ATC code	R03AC19

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07,GHS08

Signal word

Danger

Hazard statements

H302-H319-H372

Precautionary statements

P264-P280-P305+P351+P338-P337+P313P-P260-P264-P270-P314-P501-P264-P270-P301+P312-P330-P501

NFPA 704

	0
2		0

Olodaterol price More Price(14)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	21794	Olodaterol ≥98%	868049-49-4	1mg	$89	2024-03-01	Buy
Cayman Chemical	21794	Olodaterol ≥98%	868049-49-4	5mg	$289	2024-03-01	Buy
Cayman Chemical	21794	Olodaterol ≥98%	868049-49-4	10mg	$490	2024-03-01	Buy
Cayman Chemical	21794	Olodaterol ≥98%	868049-49-4	25mg	$1113	2024-03-01	Buy
Biosynth Carbosynth	FH152793	Olodaterol	868049-49-4	25mg	$325	2021-12-16	Buy

Product number	Packaging	Price	Buy
21794	1mg	$89	Buy
21794	5mg	$289	Buy
21794	10mg	$490	Buy
21794	25mg	$1113	Buy
FH152793	25mg	$325	Buy

Olodaterol Chemical Properties,Uses,Production

Description

In 2013, olodaterol (also known BI-1744 CL) was approved for the treatment of chronic obstructive pulmonary disease (COPD) in Russia (March), Canada (June), and the EuropeanUnion (October). Olodaterol is delivered via the Respimat? Soft Mist? inhaler. Olodaterol was discovered from an effort to identify a β2-adrenergic receptor agonist that could be given once daily and with a superior safety profile over known β2- adrenergic receptor agonists. Olodaterol is a potent β2 agonist (EC₅₀=0.1 nM, intrinsic activity=88%) and is highly selective for the β2 receptor over β1 and β3 receptors. In preclinical models in guinea pigs and dogs, olodaterol had a rapid onset of action and provided bronchoprotection over 24 h. Mechanistic studies indicated that olodaterol forms a highly stable complex with the β2-adrenergic receptor, with a dissociation half-life of 17.8 h. The synthesis of olodaterol proceeds through an (R)-styrene epoxide that is prepared via enantioselective reduction of an α-chloroketone intermediate. Ring opening of the epoxide with 1-(4- methoxyphenyl)-2-methylpropan-2-amine provides olodaterol.

Originator

Boehringer-Ingelheim (European Union)

Uses

Olodaterol-d3 is labelled Olodaterol (O262000) which is a long acting b-adrenoceptor agonist used as an inhalation for treating patients with chronic obstructive pulmonary disease (COPD).

Definition

ChEBI: A member of the class of benzoxazine that is 6-hydroxy-1,4-benzoxazin-3-one in which the hydrogen at position 4 is replaced by a (1R)-1-hydroxy-2-{[1-(4-methoxyphenyl)-2-methylpropan-2-yl]amino}ethyl group. Used (as its hydrochloride salt) for long-term treatment of airflow obstruction in patients with chronic obstructive pulmonary disease including chronic bronchitis and/or emphysema.

brand name

Striverdi

Olodaterol synthesis

Synthesis of Olodaterol from 8-[(1R)-1-Hydroxy-2-[[2-(4-methoxyphenyl)-1,1-dimethylethyl]amino]ethyl]-6-(phenylmethoxy)-2H-1,4-benzoxazin-3(4H)-one

Olodaterol Preparation Products And Raw materials

Raw materials

8-[(1R)-1-Hydroxy-2-[[2-(4-methoxyphenyl)-1,1-dimethylethyl]amino]ethyl]-6-(phenylmethoxy)-2H-1,4-benzoxazin-3(4H)-one 6-benzyloxy-8-((R)-2-chloro-1-hydroxy-ethyl)-4H-benzo[1,4]-oxazin-3-one

Preparation Products

Olodaterol Suppliers

Global( 99)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Yanxi Chemical Co., Ltd.	+8617531190177	peter@yan-xi.com	China	5993	58
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	15371	58
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Anhui Dexinjia Biopharm Co., Ltd	+86-531-82375818 +86-15064153060	alice@jndxj.com	China	309	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
Fuxin Pharmaceutical	+86-021-021-50872116 +8613122107989	contact@fuxinpharm.com	China	10297	58
Neostar United (Changzhou) Industrial Co., Ltd.	+86-519-519-85557386	marketing1@neostarunited.com	China	8349	58
Hebei Miaobian Biotechnology Co., Ltd	+8617733850068		CHINA	979	58

Supplier	Advantage
Hebei Yanxi Chemical Co., Ltd.	58
Shanghai Daken Advanced Materials Co.,Ltd	58
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Anhui Dexinjia Biopharm Co., Ltd	58
BOC Sciences	58
Chongqing Chemdad Co., Ltd	58
Fuxin Pharmaceutical	58
Neostar United (Changzhou) Industrial Co., Ltd.	58
Hebei Miaobian Biotechnology Co., Ltd	58

View Lastest Price from Olodaterol manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2023-09-06	olodaterol 868049-49-4	US $50.00 / KG	1KG	0.99	10000	Hebei Yanxi Chemical Co., Ltd.
2021-07-13	Olodaterol 868049-49-4	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd
2021-07-10	Olodaterol 868049-49-4	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd

olodaterol
868049-49-4
US $50.00 / KG
0.99
Hebei Yanxi Chemical Co., Ltd.

Olodaterol
868049-49-4
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

Olodaterol
868049-49-4
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

868049-49-4(Olodaterol)Related Search:

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1of4

6-Hydroxy-8-[(1R)-1-hydroxy-2-[[2-(4-methoxyphenyl)-1,1-dimethylethyl]amino]ethyl]-2H-1,4-benzoxazin-3(4H)-one 2H-1,4-Benzoxazin-3(4H)-one, 6-hydroxy-8-[(1R)-1-hydroxy-2-[[2-(4-methoxyphenyl)-1,1-dimethylethyl]amino]ethyl]- BI 1744(Olodaterol Striverdi Respimat) Olodaterol Olodaterol ImpurityＡ　 BI-1744 Striverdi Olodaterol, 98%, a long acting β2-adrenoceptor agonist OLODATEROL;BI-1744;STRIVERDI Olodaterol, 6-Hydroxy-8-[(1r)-1-hydroxy-2-[[2-(4-methoxyphenyl)-1,1-dimethylethyl]amino]ethyl]-2h-1,4-benzoxazin-3(4h)-one STRIVERDI RESPIMAT; BI 1744; BI1744 (R)-6-hydroxy-8-(1-hydroxy-2-((1-(4-methoxyphenyl)-2-methylpropan-2-yl)amino)ethyl)-2H-benzo[b][1,4]oxazin-3(4H)-one 6 - hydroxy - 8 - [(1 r) - 1 - hydroxy - 2 - [[2 - (4 - methoxy phenyl) - 1, 1-2 methyl ethyl] amino] ethyl] - 2 h - 1, 4 - benzo oxazine - 3 (4 h) - one Olodaterol USP/EP/BP Olodaterol Discontinued OLODATEROL D3 Olodaterol D3 HydrochlorideQ: What is Olodaterol D3 Hydrochloride Q: What is the CAS Number of Olodaterol D3 Hydrochloride Q: What are the applications of Olodaterol D3 Hydrochloride Olodaterol free base 6-hydroxy-8-(1-hydroxy-2-((2-(4-methoxyphenyl)-1,1-dimethylethyl)amino)ethyl)-2H-1,4-benzoxazin-3(4H)-one 868049-49-4