Calindol Hydrochloride
- CAS No.
- 729610-18-8
- Chemical Name:
- Calindol Hydrochloride
- Synonyms
- Calindol Hydrochloride;(R)-2-[[[1-(1-Naphthyl)ethyl]aMino]Methyl]-1H-indole Hydrochloride;N-[(1R)-1-(1-Naphthalenyl)ethyl]-1H-indole-2-MethanaMine Hydrochloride
- CBNumber:
- CB52486991
- Molecular Formula:
- C21H20ClN2
- Molecular Weight:
- 335.8499
- MDL Number:
- MFCD18382212
- MOL File:
- 729610-18-8.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| NFPA 704 |
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Calindol Hydrochloride price More Price(18)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 17575 | Calindol (hydrochloride) ≥98% | 729610-18-8 | 1mg | $44 | 2024-03-01 | Buy |
| Cayman Chemical | 17575 | Calindol (hydrochloride) ≥98% | 729610-18-8 | 5mg | $193 | 2024-03-01 | Buy |
| Cayman Chemical | 17575 | Calindol (hydrochloride) ≥98% | 729610-18-8 | 10mg | $341 | 2024-03-01 | Buy |
| Cayman Chemical | 17575 | Calindol (hydrochloride) ≥98% | 729610-18-8 | 25mg | $745 | 2024-03-01 | Buy |
| TRC | C148700 | CalindolHydrochloride | 729610-18-8 | 100mg | $1135 | 2021-12-16 | Buy |
Calindol Hydrochloride Chemical Properties,Uses,Production
Description
Calindol is a phenylalkylamine calcimimetic that facilitates the activation of the calcium-sensing receptor (CaSR), a G protein-
Chemical Properties
Off-White Solid
Uses
A new calcimimetic acting at the calcium sensing receptor; a positive allosteric modulator of the human Ca2+ receptor, activates an extracellular ligand-binding domain-deleted Rhodopsin-like seven-transmembrane structure in the absence of Ca2+.
in vitro
previous study found that calindol could display improved calcimimetic activity compared to its n2-(2-chloro-(or 4-fluoro-)benzyl)-n1-(1-(1-naphthyl)ethyl)-3-phenylpropane-1,2-diamine analogs as well as stereoselectivity. in the presence of 2 mm ca(2+), calindol was able to stimulate [(3)h]inositol phosphates accumulation with an ec(50) of 1.0+/-0.1 or 0.31+/-0.05 μm in cells expressing the rat or the human casr, respectively. therefore, such calcimimetic activities of this novel compound were shown to be because of a specific interaction with the casr [1].
References
[1] kessler, a. ,faure, h.,petrel, c., et al. n2-benzyl-n1-(1-(1-naphthyl)ethyl)-3-phenylpropane-1,2-diamines and conformationally restrained indole analogues: development of calindol as a new calcimimetic acting at the calcium sensing receptor. bioorganic & medicinal chemistry letters 14(12), 3345-3349 (2004).
Calindol Hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Calindol Hydrochloride Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32344 | 50 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 13028896684 | sales@rrkchem.com | China | 55672 | 58 |
| BOC Sciences | -- | info@bocsci.com | USA | 0 | 65 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 8740 | 58 |
| Shanghai Aladdin Biochemical Technology Co.,Ltd. | +86-18521732826 | market@aladdin-e.com | China | 46692 | 58 |
| Carbosynth | -- | sales@carbosynth.com | United Kingdom | 6018 | 58 |
| ApexBio Technology | -- | sales@apexbt.com | United States | 6254 | 58 |