Piperazine, 1-diphenylmethyl-4-methyl-, dihydrochloride
- CAS No.
- 5897-18-7
- Chemical Name:
- Piperazine, 1-diphenylmethyl-4-methyl-, dihydrochloride
- Synonyms
- Cyclizine 2HCl;Marzine hydrochloride;Cyclizine 2hydrochloride;Cyclizine dihydrochloride;Piperazine, 1-benzhydryl-4-methyl-, dihydrochloride;1-Diphenylmethyl-4-methylpiperazine dihydrochloride;Piperazine, 1-diphenylmethyl-4-methyl-, dihydrochloride;Piperazine, 1-(diphenylmethyl)-4-methyl-, hydrochloride (1:2);Piperazine, 1-diphenylmethyl-4-methyl-, dihydrochloride USP/EP/BP
- CBNumber:
- CB52497865
- Molecular Formula:
- C18H24Cl2N2
- Molecular Weight:
- 339.30256
- MDL Number:
- MFCD01702954
- MOL File:
- 5897-18-7.mol
- MSDS File:
- SDS
| storage temp. | Inert atmosphere,Store in freezer, under -20°C |
|---|---|
| solubility | Soluble in DMSO > 10 mM |
| form | Powder |
| EWG's Food Scores | 1 |
| FDA UNII | VF601QVZ67 |
Piperazine, 1-diphenylmethyl-4-methyl-, dihydrochloride price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| AK Scientific | 2344AH | Cyclizine2HCl | 5897-18-7 | 25mg | $129 | 2021-12-16 | Buy |
| ApexBio Technology | B1548 | Cyclizine2HCl | 5897-18-7 | 50mg | $146 | 2021-12-16 | Buy |
| CSNpharm | CSN22573 | Cyclizine2HCl | 5897-18-7 | 10mg | $36 | 2021-12-16 | Buy |
| CSNpharm | CSN22573 | Cyclizine2HCl | 5897-18-7 | 50mg | $61 | 2021-12-16 | Buy |
Piperazine, 1-diphenylmethyl-4-methyl-, dihydrochloride Chemical Properties,Uses,Production
Biological Activity
Cyclizine 2HCl is a piperazine derivative with Histamine H1 receptor antagonist activity.
in vitro
Cyclizine is a piperazine histamine H1 receptor antagonist and has anticholinergic and antiemetic properties. It increases lower esophageal sphincter tone and reduces the sensitivity of tortuous organs.
in vivo
Cyclizine is metabolized to its N-desmethyl derivative, Norcyclizine, which has little antihistamine (H1) activity compared to Cyclizine. After oral administration of Cyclizine, the effect will be produced within 30 minutes, and the maximum effect will be achieved within 1-2 hours, which can last for 4-6 hours. Cyclizine administered orally at a dose of 50 mg alone in healthy adult volunteers produced peak plasma concentrations of approximately 70 ng/mL two hours after dosing. The plasma elimination half-life is about 20 hours.
target
| Target | Value |
| Histamine H1 receptor |
Piperazine, 1-diphenylmethyl-4-methyl-, dihydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Piperazine, 1-diphenylmethyl-4-methyl-, dihydrochloride Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29067 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Guangzhou Tomums Life Science Co., Ltd. | 020-31155029 18902330969 | sales@tomums.cn | China | 4698 | 58 |
| Absin Bioscience Inc. | 021-38015121 15000105423 | chenjw@absin.cn | China | 24734 | 58 |
| Shanghai hongqu biomedical technology co. LTD | 88888888888 | hongquchem@qq.com | China | 5132 | 58 |
| Beijing Aomi Jiade Pharmaceutical Technology Co., Ltd | 13522808617 | omiget@qq.com | China | 9213 | 58 |
| Wuhan Yanzhe Technology Co., Ltd | 15527250409 | wenhaotian12@163.com | China | 4576 | 58 |