CP-724714
- CAS No.
- 537705-08-1
- Chemical Name:
- CP-724714
- Synonyms
- CS-521;CS-2401;CP-724714;(E/Z)-CP-724714;CP-724714 CP724714;CP-724714 USP/EP/BP;-Ethyl (3-(4-((3-methyl-4-((6-methylpyridin-3-yl);2H-1,4-Benzoxazine-7-carboxylicacid,3,8-dihydro-,methylester;(E)-Ethyl (3-(4-((3-methyl-4-((6-methylpyridin-3-yl)-oxy)phenyl)amino)quinazolin-6-yl)allyl)ca;(E)-Ethyl (3-(4-((3-methyl-4-((6-methylpyridin-3-yl)-oxy)phenyl)amino)quinazolin-6-yl)allyl)carba
- CBNumber:
- CB52501007
- Molecular Formula:
- C27H27N5O3
- Molecular Weight:
- 469.54
- MDL Number:
- MFCD19687281
- MOL File:
- 537705-08-1.mol
| solubility | ≥23.5 mg/mL in DMSO; insoluble in H2O; ≥25.4 mg/mL in EtOH |
|---|---|
| form | solid |
| NCI Dictionary of Cancer Terms | CP-724; 714 |
| FDA UNII | I05QZ0S4V3 |
| NCI Drug Dictionary | CP-724,714 |
CP-724714 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ApexBio Technology | A2412 | CP-724714 | 537705-08-1 | 5mg | $85 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CHM0392155 | (E)-ETHYL-(3-(4-((3-METHYL-4-((6-METHYLPYRIDIN-3-YL)OXY)PHENYL)AMINO)QUINAZOLIN-6-YL)ALLYL)CARBAMATE 95.00% | 537705-08-1 | 5MG | $499.15 | 2021-12-16 | Buy |
| AK Scientific | X7480 | (E)-Ethyl(3-(4-((3-methyl-4-((6-methylpyridin-3-yl)oxy)pheny)amino)quinazolin-6-yl)allyl)carbamate | 537705-08-1 | 25mg | $540 | 2021-12-16 | Buy |
| Chemenu | CM133309 | ethyl(E)-(3-(4-((3-methyl-4-((6-methylpyridin-3-yl)oxy)phenyl)amino)quinazolin-6-yl)allyl)carbamate 95% | 537705-08-1 | 5g | $795 | 2021-12-16 | Buy |
| DC Chemicals | DC8892 | CP724714 >98% | 537705-08-1 | 250mg | $900 | 2021-12-16 | Buy |
CP-724714 Chemical Properties,Uses,Production
Uses
CP-724,714 is a potent, selective inhibitor of HER2/ErbB2 with IC50 of 10 nM and also inhibits EGFR with IC50 of 6.4 μM.
Biological Activity
cp-724714 is an inhibitor of erbb2 and egfr kinases with ic50 values of 10±3 nmol/l and 6,400±2,100 nmol/l, respectively [1].in the in vitro cell cycle assay, cp-724714 cause a g1 block of the her2-amplified bt-474 breast cancer cells due to its inhibition of erbb2. cp-724714 at 1 mol/l can also reduce the level of phospho-erbb2 in these cells. in in vivo assay, cp-724714 cause a concentration-dependent reduction of tumor erbb2 receptor phosphorylation in athymic mice bearing fre-erbb2xenografts. cp-724714 treatments also resulted in a time- and dose-dependent induction of tumor cell apoptosis. in two human breast carcinoma models, bt-474 and mda-mb-453, which are her2 amplified and highly overexpress erbb2, cp-724714 is found to produce a dose-dependent inhibition of xenograft growth. in addition, cp-724,714 treatments induce reduction of downstream erbb2 rtk signaling. on the basis of these, cp-724,714 was advanced to phase i clinical trials and is potentially another option for her2-driven breast cancer [1].
target
erbB2
References
[1] jitesh p. jani, richard s. finn, mary campbell, et al. discovery and pharmacologic characterization of cp-724714, a selective erbb2 tyrosine kinase inhibitor. cancer research. 2007 (67): 9887-9893.
CP-724714 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29271 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Hebei Duling International Trade Co. LTD | +8618032673083 | sales05@hbduling.cn | China | 15745 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
