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2-Fluoro-5-((3-oxoisobenzofuran-1(3H)-ylidene)methyl)benzonitrile

2-Fluoro-5-((3-oxoisobenzofuran-1(3H)-ylidene)methyl)benzonitrile structure

CAS No.: 763114-25-6

Chemical Name:: 2-Fluoro-5-((3-oxoisobenzofuran-1(3H)-ylidene)methyl)benzonitrile

Synonyms: (Z)-2-fluoro-5-((3-oxoisobenzofuran-1(3H)-ylidene)Methyl)benzonitrile;2-Fluoro-5-(3-oxo-3H-isobenzofuran-1-ylidenemethyl)-benzonitrile;2-fluoro-5-((3-oxoisobenzofuran-1(3H)-ylidene)Methyl)benzonitrile;2-fluoro-5-[(Z)-(3-oxo-2-benzofuran-1-ylidene)methyl]benzonitrile;Olaparib Impurity 76;2-Fluoro-5-[(3-oxo-1(3H)-isobenzofuranylidene)meth;2-Fluoro-5-[(3-oxo-1(3H)-isobenzofuranylidene)methyl]benzoni...;2-Fluoro-5-[(3-oxo-1(3H)-isobenzofuranylidene)methyl]-benzonitrile;Benzonitrile, 2-fluoro-5-[(3-oxo-1(3H)-isobenzofuranylidene)methyl]-;(E)-2-fluoro-5-((3-oxoisobenzofuran-1(3H)-ylidene)methyl)benzonitrile

CBNumber:: CB52506451

Molecular Formula:: C16H8FNO2

Molecular Weight:: 265.24

MDL Number:: MFCD13181869

MOL File:: 763114-25-6.mol

Last updated:2024-01-16 18:38:52

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2-Fluoro-5-((3-oxoisobenzofuran-1(3H)-ylidene)methyl)benzonitrile Properties

Boiling point	430.1±45.0 °C(Predicted)
Density	1.38
storage temp.	Sealed in dry,Room Temperature
solubility	Dichloromethane, Tetrahydrofuran
form	Solid
color	White
InChI	InChI=1S/C16H8FNO2/c17-14-6-5-10(7-11(14)9-18)8-15-12-3-1-2-4-13(12)16(19)20-15/h1-8H
InChIKey	MMPHWTMMVPBHRZ-UHFFFAOYSA-N
SMILES	C(#N)C1=CC(C=C2C3=C(C=CC=C3)C(=O)O2)=CC=C1F

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H332-H335
Precautionary statements	P261-P280-P305+P351+P338
HS Code	2932990090

2-Fluoro-5-((3-oxoisobenzofuran-1(3H)-ylidene)methyl)benzonitrile price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	F595100	2-Fluoro-5-[(3-oxo-1(3H)-isobenzofuranylidene)methyl]-benzonitrile	763114-25-6	2.5g	$1320	2021-12-16	Buy
Apolloscientific	PC51400	2-Fluoro-5-(3-oxo-3H-isobenzofuran-1-ylidenemethyl)-benzonitrile 97%	763114-25-6	25g	$402	2021-12-16	Buy
American Custom Chemicals Corporation	HCH0416676	2-FLUORO-5-[(3-OXO-1(3H)-ISOBENZOFURANYLIDENE)METHYL]-BENZONITRILE 95.00%	763114-25-6	5MG	$503.9	2021-12-16	Buy
Medical Isotopes, Inc.	58170	2-Fluoro-5-[(3-oxo-1(3H)-isobenzofuranylidene)methyl]-benzonitrile	763114-25-6	250mg	$650	2021-12-16	Buy
Matrix Scientific	096539	2-Fluoro-5-((3-oxoisobenzofuran-1(3H)-ylidene)methyl)benzonitrile 95+%	763114-25-6	1g	$706	2021-12-16	Buy

Product number	Packaging	Price	Buy
F595100	2.5g	$1320	Buy
PC51400	25g	$402	Buy
HCH0416676	5MG	$503.9	Buy
58170	250mg	$650	Buy
096539	1g	$706	Buy

2-Fluoro-5-((3-oxoisobenzofuran-1(3H)-ylidene)methyl)benzonitrile Chemical Properties,Uses,Production

Chemical Properties

White Solid

Uses

2-Fluoro-5-[(3-oxo-1(3H)-isobenzofuranylidene)methyl]-benzonitrile is intermediate in the preparation of poly (ADP-ribose) polymerase (PARP) inhibitors. Olaparib intermediate.

Synthesis

(3-oxo-1,3-dihydroisobenzofuran-1-yl)phosphonic acid (5.00 g, 0.021 mol) in tetrahydrofuran (30 mL) was added to a 150 mL round-bottom flask. To this solution, triethylamine(5.6 mL, 0.042 mol) was added. 2-Fluoro-5-formyl benzonitrile( 3.08 g, 0.021 mol) was dissolved in tetrahydrofuran into another round-bottom flask, followed by adding triethylamine (2.9 mL, 0.021 mol) and stirring evenly. Then the reaction fluids in the two flasks were mixed and reacted at room temperature for 12 h. The product was concentrated under reduced pressure and 50 mL of water was added. The suspension was stirred for 30 min until the solids were not precipitated. Finally, filtration was performed, and the filter cake was collected and dried to obtain 2-Fluoro-5-[(3-oxo-1(3H)-isobenzofuranylidene)methyl]-benzonitrile(5.41 g, 97%).

2-Fluoro-5-((3-oxoisobenzofuran-1(3H)-ylidene)methyl)benzonitrile synthesis

Synthesis of 2-Fluoro-5-((3-oxoisobenzofuran-1(3H)-ylidene)methyl)benzonitrile from Benzonitrile, 5-ethenyl-2-fluoro- and 3-oxo-1,3-dihydroisobenzofuran-1-ylphosphonic acid

2-Fluoro-5-((3-oxoisobenzofuran-1(3H)-ylidene)methyl)benzonitrile Preparation Products And Raw materials

Raw materials

Benzonitrile, 5-ethenyl-2-fluoro- 3-oxo-1,3-dihydroisobenzofuran-1-ylphosphonic acid 2-FLUORO-5-FORMYLBENZONITRILE

Preparation Products

2-Fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzonitrile 2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzoic acid

2-Fluoro-5-((3-oxoisobenzofuran-1(3H)-ylidene)methyl)benzonitrile Suppliers

Global( 204)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
PharmOrgSyn Laboratories Co., Ltd.	+86-021-38228826 +86-13916602830	sales@pharmorgsyn.cn	China	140	58
Shanghai Boc Chemical Co., Ltd.	021-34975602; +8618721111801	shangli@bocchem.com	China	138	58
Golden Pharma Co., Limited	+undefined18958062155	sales@zjgoldpharm.com	China	5905	58
Jiangxi Chiyan Biopharmaceutical Technology Co.,Ltd.	+86-18616643091 +86-18616643091	info@rochipharma.com	China	246	58
Zhejiang Brunova Technology Co., Ltd.	8617857108485 17857108485	info@zjbrunova.com	China	37	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	7845	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1811	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21691	55
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58

Supplier	Advantage
PharmOrgSyn Laboratories Co., Ltd.	58
Shanghai Boc Chemical Co., Ltd.	58
Golden Pharma Co., Limited	58
Jiangxi Chiyan Biopharmaceutical Technology Co.,Ltd.	58
Zhejiang Brunova Technology Co., Ltd.	58
Henan Fengda Chemical Co., Ltd	58
Capot Chemical Co.,Ltd.	60
Beijing Cooperate Pharmaceutical Co.,Ltd	55
Henan Tianfu Chemical Co.,Ltd.	55
career henan chemical co	58

View Lastest Price from 2-Fluoro-5-((3-oxoisobenzofuran-1(3H)-ylidene)methyl)benzonitrile manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-01-16	2-Fluoro-5-[(3-oxo-1(3H)-isobenzofuranylidene)methyl]-benzonitrile 763114-25-6	US $5.00-1.00 / KG	1KG	99%	g-kg-tons, free sample is available	Henan Fengda Chemical Co., Ltd
2023-12-27	2-Fluoro-5-[(3-oxo-1(3H)-isobenzofuranylidene)methyl]-benzonitrile 763114-25-6	US $0.00-0.00 / kg	1kg	98%	1 ton	Nanjing Fred Technology Co., Ltd
2023-06-09	2-Fluoro-5-[(3-oxo-1(3H)- isobenzofuranylidene)methyl]-benzonitrile 763114-25-6	US $0.00-0.00 / Kg	1Kg	99%，USP/CP/EP	1-10000kgs	Changzhou Rokechem Technology Co., Ltd.

2-Fluoro-5-[(3-oxo-1(3H)-isobenzofuranylidene)methyl]-benzonitrile
763114-25-6
US $5.00-1.00 / KG
99%
Henan Fengda Chemical Co., Ltd

2-Fluoro-5-[(3-oxo-1(3H)-isobenzofuranylidene)methyl]-benzonitrile
763114-25-6
US $0.00-0.00 / kg
98%
Nanjing Fred Technology Co., Ltd

2-Fluoro-5-[(3-oxo-1(3H)- isobenzofuranylidene)methyl]-benzonitrile
763114-25-6
US $0.00-0.00 / Kg
99%，USP/CP/EP
Changzhou Rokechem Technology Co., Ltd.

763114-25-6(2-Fluoro-5-((3-oxoisobenzofuran-1(3H)-ylidene)methyl)benzonitrile)Related Search:

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2-Fluoro-5-[(3-oxo-1(3H)-isobenzofuranylidene)methyl]-benzonitrile 2-fluoro-5-(3-oxo-1,3-dihydroisobenzofuranylidene methyl)benzonitrile (E)-2-fluoro-5-((3-oxoisobenzofuran-1(3H)-ylidene)methyl)benzonitrile Benzonitrile, 2-fluoro-5-[(3-oxo-1(3H)-isobenzofuranylidene)methyl]- 2-Fluoro-5-[(3-oxo-1(3H)-isobenzofuranylidene)meth 2-Fluoro-5-[(3-oxo-1(3H)-isobenzofuranylidene)methyl]benzoni... 2-fluoro-5-[(3-oxo-1,3-dihydro-2-benzofuran-1-ylidene)methyl]benzonitrile C16H8FNO2 2-Fluoro-5-[(3-oxo-1(3H)-isobenzofuranylidene)methyl]-benzonitrile 763114-25-6 (Z)-2-fluoro-5-((3-oxoisobenzofuran-1(3H)-ylidene)Methyl)benzonitrile 2-fluoro-5-((3-oxoisobenzofuran-1(3H)-ylidene)Methyl)benzonitrile 2-Fluoro-5-(3-oxo-3H-isobenzofuran-1-ylidenemethyl)-benzonitrile 2-fluoro-5-[(Z)-(3-oxo-2-benzofuran-1-ylidene)methyl]benzonitrile Olaparib Impurity 76 2- Fluoro-5-[(3-oxo-1(3H)-isobenzo-furanylidene)-methyI]I- benzonitrile 763114-25-6 C16H8FNO2 trebectedin