5-Methyl-N-phenyl-2-1H-pyridone-d5 ( Pirfenidone-d5 )
- CAS No.
- 1020719-62-3
- Chemical Name:
- 5-Methyl-N-phenyl-2-1H-pyridone-d5 ( Pirfenidone-d5 )
- Synonyms
- AMR69 D5;[2H5]-Pirfenidone;2(1H)-Pyridinone, 5-Methyl-1-phenyl-d5-;2(1H)-Pyridinone, 5-methyl-1-(phenyl-2,3,4,5,6-d5)-;Pirfenidone-d5 (5-Methyl-N-Phenyl-2-1H-Pyridone-d5)?;5-Methyl-N-phenyl-2-1H-pyridone-d5 ( Pirfenidone-d5 );5-methyl-1-(2,3,4,5,6-pentadeuteriophenyl)pyridin-2-one;5-Methyl-1-(phenyl-2,3,4,5,6-d5)-2(1H)-pyridinone;Pirfenidone-d5Q: What is Pirfenidone-d5 Q: What is the CAS Number of Pirfenidone-d5 Q: What is the storage condition of Pirfenidone-d5 Q: What are the applications of Pirfenidone-d5
- CBNumber:
- CB52511343
- Molecular Formula:
- C12H11NO
- Molecular Weight:
- 185.23
- MDL Number:
- MFCD07369537
- MOL File:
- 1020719-62-3.mol
- MSDS File:
- SDS
| Melting point | 104-106°C |
|---|---|
| storage temp. | -20°C Freezer |
| solubility | Chloroform (Slightly), Ethanol, Ethyl Acetate, Methanol (Slightly) |
| form | Solid |
| color | White to Light Beige |
| InChI | InChI=1S/C12H11NO/c1-10-7-8-12(14)13(9-10)11-5-3-2-4-6-11/h2-9H,1H3 |
| InChIKey | ISWRGOKTTBVCFA-UHFFFAOYSA-N |
| SMILES | O=C1C=CC(C)=CN1C1C([H])=C([H])C([H])=C([H])C=1[H] |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P330-P501 | |||||||||
| NFPA 704 |
|
5-Methyl-N-phenyl-2-1H-pyridone-d5 ( Pirfenidone-d5 ) price More Price(8)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 26452 | Pirfenidone-d5 | 1020719-62-3 | 500μg | $106 | 2024-03-01 | Buy |
| Cayman Chemical | 26452 | Pirfenidone-d5 | 1020719-62-3 | 1mg | $178 | 2024-03-01 | Buy |
| TRC | M325898 | 5-Methyl-N-phenyl-2-1H-pyridone-d5(Pirfenidone-d5) | 1020719-62-3 | 10mg | $1230 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | RDL0007218 | 5-METHYL-N-PHENYL-2-1H-PYRIDONE-D5 95.00% | 1020719-62-3 | 10MG | $1593.9 | 2021-12-16 | Buy |
| AK Scientific | 8703DU | 5-Methyl-N-phenyl-2-1H-pyridone-d5 | 1020719-62-3 | 1mg | $370 | 2021-12-16 | Buy |
5-Methyl-N-phenyl-2-1H-pyridone-d5 ( Pirfenidone-d5 ) Chemical Properties,Uses,Production
Description
Pirfenidone-d5 is intended for use as an internal standard for the quantification of pirfenidone by GC- or LC-MS. Pirfenidone is an orally bioavailable pyridone derivative with antifibrotic, anti-inflammatory, and antioxidant activities. It inhibits TGF-β1-stimulated increases in collagen type I, fibronectin, and Hsp47 expression in A549 lung cancer cells in a concentration-dependent manner. Pirfenidone (300 mg/kg per day) inhibits fibrosis and inhibits increases in collagen content, fibrocyte pool size, and the levels of chemokines CCL2 and CCL12 in lung in a mouse model of pulmonary fibrosis induced by bleomycin . In a mouse model of non-alcoholic steatohepatitis (NASH), pirfenidone inhibits fibrosis and increases in hepatocyte apoptosis, lobular inflammation, and hepatic expression of the fibrosis-related genes Col1a1, Timp1, Tgfb1, Pdgfb, and Fgf2 when administered at a dose of 280 mg/kg but has no effect on steatosis. Pirfenidone also inhibits NADPH-dependent lipid peroxidation in sheep liver microsomes and scavenges hydroxyl radicals (IC50s = ~6 and ~2.5 mM, respectively). Formulations containing pirfenidone have been used in the treatment of idiopathic pulmonary fibrosis.
Chemical Properties
Off-White Solid
Uses
A deuterated metabolite of Pirfenidone, a new drug to treat patients with kidney disease who have diabetes.
5-Methyl-N-phenyl-2-1H-pyridone-d5 ( Pirfenidone-d5 ) Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32344 | 50 |
| Hangzhou Sage Chemical Co., Ltd. | +86057186818502 13588463833 | info@sagechem.com | China | 10269 | 58 |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 | sales-cpd@caerulumpharma.com | China | 3419 | 58 |