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2-Thiobarbituric acid

CAS No.
504-17-6
Chemical Name:
2-Thiobarbituric acid
Synonyms
TBA;THIOBARBITURIC ACID;2-Thioxodihydropyrimidine-4,6(1H,5H)-dione;2-sulfanylpyriMidine-4,6-diol;4,6-DIHYDROXY-2-MERCAPTOPYRIMIDINE;bathyran;austranal;usafek-660;2-Mercapto-4;Thiobarbituric
CBNumber:
CB5251676
Molecular Formula:
C4H4N2O2S
Molecular Weight:
144.15
MDL Number:
MFCD00006674
MOL File:
504-17-6.mol
MSDS File:
SDS
Last updated:2024-03-13 14:26:59

2-Thiobarbituric acid Properties

Melting point 245 °C (dec.)(lit.)
Density 1.451 (estimate)
refractive index 1.7690 (estimate)
storage temp. Inert atmosphere,2-8°C
solubility 50g/l slightly soluble
form Liquid
pka 3.96±0.20(Predicted)
color Clear colorless
PH 1.7-1.9 (10g/l, H2O, 20℃)
Water Solubility <6 g/L (20 ºC)
BRN 120663
Stability Stable. Incompatible with strong oxidizing agents.
InChIKey RVBUGGBMJDPOST-UHFFFAOYSA-N
CAS DataBase Reference 504-17-6(CAS DataBase Reference)
FDA UNII M1YZW5SS7C
NIST Chemistry Reference 4,6(1H,5h)-pyrimidinedione, dihydro-2-thioxo-(504-17-6)
EPA Substance Registry System 4,6(1H,5H)-Pyrimidinedione, dihydro-2-thioxo- (504-17-6)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P280a-P304+P340-P305+P351+P338-P405-P501a
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  22-24/25-37/39-26
RIDADR  UN 3335
WGK Germany  2
RTECS  CQ7700000
13-23
TSCA  Yes
HS Code  29335995
NFPA 704
1
2 0

2-Thiobarbituric acid price More Price(29)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich T5500 2-Thiobarbituric acid ≥98% 504-17-6 25g $51.4 2024-03-01 Buy
Sigma-Aldrich T5500 2-Thiobarbituric acid ≥98% 504-17-6 100g $146 2024-03-01 Buy
Cayman Chemical 27367 2-Thiobarbituric Acid 504-17-6 50g $68 2024-03-01 Buy
Cayman Chemical 27367 2-Thiobarbituric Acid 504-17-6 250g $283 2024-03-01 Buy
Sigma-Aldrich T5500 2-Thiobarbituric acid ≥98% 504-17-6 250g $336 2024-03-01 Buy
Product number Packaging Price Buy
T5500 25g $51.4 Buy
T5500 100g $146 Buy
27367 50g $68 Buy
27367 250g $283 Buy
T5500 250g $336 Buy

2-Thiobarbituric acid Chemical Properties,Uses,Production

Chemical Properties

Off-White to Yellow Powder. soluble in hot water, alcohol, ether, alkali and sodium carbonate solution, slightly soluble in water.

Uses

4,6-Dihydroxy-2-mercaptopyrimidine can be used to quantitate lipopolysaccharides, carrageenan, and sialic acids, and to detect lipid hydroperoxides and lipid oxidation.

Uses

2-Thiobarbituric acid has been used to measure malondialdehyde (MDA) in lipid peroxidation assay.

Definition

ChEBI: 2-thiobarbituric acid is a barbiturate, the structure of which is that of barbituric acid in which the oxygen at C-2 is replaced by sulfur. It has a role as a reagent and an allergen.

Preparation

2-thiobarbituric acid was synthesized by the reaction of diethyl malonate with thiourea. Dissolve thiourea in methanol, add sodium methoxide and diethyl malonate, heat under reflux for 4-5h, then distill under reduced pressure to recover methanol to the end, and add hydrochloric acid to acidify to pH 1-2 after cooling. After standing overnight, thiobarbituric acid crystals were precipitated, filtered, and recrystallized with water to obtain the pure product.

General Description

2-Thiobarbituric acid is a molecule made up of heteroatoms: nitrogen, sulphur and oxygen.

Biochem/physiol Actions

2-Thiobarbituric acid (TBA) is useful to quantitate lipopolysaccharides, carrageenan, and sialic acids. It is also used to detect lipid hydroperoxides and lipid oxidation. It has applications in the field of medicine and biochemistry. TBA may possess the ability to prevent metal corrosion.

Purification Methods

Crystallise it from water. [Beilstein 24 H 476, 24 I 414, 24 II 275, 24 III/IV 1884.]

17356-08-0
105-53-3
504-17-6
Synthesis of 2-Thiobarbituric acid from Carbamimidothioic acid and Diethyl malonate

2-Thiobarbituric acid Preparation Products And Raw materials

Global( 483)Suppliers
Supplier Tel Email Country ProdList Advantage
Tangshan Moneide Trading Co., Ltd.
+86-315-8309571 +8615633399667 sales@moneidechem.com China 568 58
Hebei Mojin Biotechnology Co., Ltd
+86-13288715578 +86-13231137666 sales@hbmojin.com China 12409 58
Hebei Yanxi Chemical Co., Ltd.
+8617531190177 peter@yan-xi.com China 5960 58
Anhui Ruihan Technology Co., Ltd
+8617756083858 daisy@anhuiruihan.com China 994 58
Henan Fengda Chemical Co., Ltd
+8613613820652 info@fdachem.com China 4685 58
Capot Chemical Co.,Ltd.
571-85586718 +8613336195806 sales@capotchem.com China 29797 60
Beijing Cooperate Pharmaceutical Co.,Ltd
010-60279497 sales01@cooperate-pharm.com CHINA 1811 55
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21703 55
career henan chemical co
+86-0371-86658258 sales@coreychem.com China 29919 58
Hubei Jusheng Technology Co.,Ltd.
18871490254 linda@hubeijusheng.com CHINA 28180 58

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View Lastest Price from 2-Thiobarbituric acid manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Thiobarbituric acid pictures 2024-02-18 Thiobarbituric acid
504-17-6
US $350.00 / g 1g 97 500 Kg R&D Scientific Inc.
4,6-Dihydroxy-2-mercaptopyrimidine pictures 2024-01-14 4,6-Dihydroxy-2-mercaptopyrimidine
504-17-6
US $10.00-0.80 / KG 1KG 99% g-kg-tons, free sample is available Henan Fengda Chemical Co., Ltd
2-thiobarbituric acid pictures 2023-12-13 2-thiobarbituric acid
504-17-6
US $0.00-0.00 / kg 1kg 99% 50000kg Hebei Yibangte Import and Export Co. , Ltd.
austranal bathyran Dihydro-2-thioxo-4,6-(1H,5H)-pyrimidinedione dihydro-2-thioxo-4,6(1h,5h)-pyrimidinedione Mealonylthiourea Thiobarbituicacid Thiobarbituric 2-THIOBARBITURICACID,REAGENT 2-MERCAPTO-4,6-DIHYDROXYPYRIMIDINE (2-THIOBARBITURIC ACID) ThiobarbituricAcidGr 1-ThioglycerolGr90% 2-ThiobarbituricAcid98% 4,6(1H,5H)-Pyrimidinedione, dihydro-2-thioxo- (9CI) 4,6(1H,5H)-PYRIMIDINEDIONE, DIHYDRO-2-THIOXO- 4,6-DIHYDROXY-2-THIOPYRIMIDINE 4,6-DIHYDROXYPYRIMIDINE-2-THIOL 2-thiobarbituric acid minimum 98% Thiobarbituric Acid, 2- 4,6-Dihydroxy-2-mercaptopyrimidine, 4,6-Dihydroxypyrimidine-2-thiol, TBA 2-Thio-4,6-dioxypyrimidine 2-Thioxo-6-hydroxy-1,2,3,4-tetrahydropyrimidine-4-one 6-Hydroxy-2-thioxo-1,2-dihydropyrimidin-4(3H)-one 2,3-Dihydro-2-thioxo-4,6(1H,5H)-pyrimidinedione 4,6-Dihydroxy-2-mercaptopyrimidine,98% 3,4-Dihydroxy-2-mercaptopyrimidine 2-Thioxo-dihydro-pyrimidine-4,6-dione usafek-660 4,6-Dihydroxypyrimidine-2-thiol ( 2-Thiobarbitursure) 2-THIOBARBITURIC ACIDANALYTICAL GRADE MALONYLTHIOUREA LABOTEST-BB LT00440785 AURORA KA-3842 2-MERCAPTO-4,6-DIHYDROXY-PYRIMIDINE 2-THIOBARBITURIC ACID 2-Mercapto-4 2-Thiobarbituric Acid [for BiocheMical Research] 4,6-Dihydroxy-2-MercaptopyriMidine, 98% 100GR 4,6-Dihydroxy-2-MercaptopyriMidine, 98% 5GR 4.6-Dihydroxy-2-mercaptopyrimidine 1g [504-17-6] 2-Thiobarbituric acid p.a. 4,6-Dihydroxy-2-merc 4,6-DihydroxypyriMidine-2-thiol (2-Thiobarbitursre) 2-THIOBARBITURIC ACID REAGENT FOR SORBIC HexahydropyriMidine-4,6-dione-2-thione Thiobarbituric aci thiobarbituric acid (TBA) 2 - Mercapto - 4, 6-2 hydroxy pyriMidine 2-Thiobarbituric acid Vetec(TM) reagent grade, >=98% 2-Thiobarbituric acid(TBA) 2-Mercaptopyrimidine-4,6-dione TIMTEC-BB SBB004132 2-mercaptobarbituricacid 2-thio-barbituricaci 5h)-pyrimidinedione,dihydro-2-thioxo-6(1h 6(1H,5H)-Pyrimidinedione,dihydro-2-thioxo-4 2-Thiobarbituric Acid > 2-Thiobarbituric acid ISO 9001:2015 REACH 2-Thiobarbituric acid 4,6-Dihydroxy-2-mercaptopyrimidine