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3-Cyano-4-phenyl-6-(3-bromo-6-hydroxy)phenyl-2(1H)-pyridone

3-Cyano-4-phenyl-6-(3-bromo-6-hydroxy)phenyl-2(1H)-pyridone structure

CAS No.: 491871-58-0

Chemical Name:: 3-Cyano-4-phenyl-6-(3-bromo-6-hydroxy)phenyl-2(1H)-pyridone

Synonyms: CS-1482;TCS PIM-1;SC 204330;TCS PIM-1 1;TCS PIM-1 1, >=98%;TCS PIM-1 1(sc-204330);SC 204330; TCS PIM 1-1;3-Cyano-4-phenyl-6-(3-bromo-6-hydroxy)phenyl-2(1H)-pyridone;6-(5-Bromo-2-hydroxyphenyl)-1,2-dihydro-2-oxo-4-phenyl-3-pyridinecarbonitrile;3-Pyridinecarbonitrile, 6-(5-bromo-2-hydroxyphenyl)-1,2-dihydro-2-oxo-4-phenyl-

CBNumber:: CB52518751

Molecular Formula:: C18H11BrN2O2

Molecular Weight:: 367.2

MDL Number:: MFCD00276275

MOL File:: 491871-58-0.mol

MSDS File:: SDS

Last updated:2023-06-30 15:45:59

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3-Cyano-4-phenyl-6-(3-bromo-6-hydroxy)phenyl-2(1H)-pyridone Properties

Boiling point	592.6±50.0 °C(Predicted)
Density	1.63±0.1 g/cm3(Predicted)
storage temp.	Store at +4°C
solubility	insoluble in H2O; insoluble in EtOH; ≥12.8 mg/mL in DMSO
form	solid
pka	6.93±0.10(Predicted)

3-Cyano-4-phenyl-6-(3-bromo-6-hydroxy)phenyl-2(1H)-pyridone price More Price(27)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	16286	TCS PIM-1 1 ≥98%	491871-58-0	5mg	$97	2024-03-01	Buy
Cayman Chemical	16286	TCS PIM-1 1 ≥98%	491871-58-0	10mg	$155	2024-03-01	Buy
Cayman Chemical	16286	TCS PIM-1 1 ≥98%	491871-58-0	50mg	$360	2024-03-01	Buy
Cayman Chemical	16286	TCS PIM-1 1 ≥98%	491871-58-0	100mg	$672	2024-03-01	Buy
Tocris	2979	TCSPIM-11 ≥98%(HPLC)	491871-58-0	50	$716	2021-12-16	Buy

Product number	Packaging	Price	Buy
16286	5mg	$97	Buy
16286	10mg	$155	Buy
16286	50mg	$360	Buy
16286	100mg	$672	Buy
2979	50	$716	Buy

3-Cyano-4-phenyl-6-(3-bromo-6-hydroxy)phenyl-2(1H)-pyridone Chemical Properties,Uses,Production

Uses

TCS PIM-1 1 is a Pim-1 kinase inhibitor.

Definition

ChEBI: 3-cyano-4-phenyl-6-(3-bromo-6-hydroxyphenyl)-2-pyridone is a member of the class of pyridones that is 2-pyridone carrying cyano, phenyl and 3-bromo-6-hydroxyphenyl substituents at positions 3, 4 and 6 respectively It is a pyridone, a bromophenol and a nitrile.

Biological Activity

tcs pim-1 1 is a selective inhibitor of pim-1 with ic50 value of 50 nm [1].pim-1 is a proto-oncogene serine/threonine-protein kinase and plays an important role in cell cycle progression, apoptosis, transcriptional activation and more general signal transduction pathways. it has been shown that pim-1 over-expression is correlated with a variety of human cancers [2].tcs pim-1 1 is a potent pim-1 inhibitor and has a better selectivity to pim-1 than to pim-2. it was revealed that tcs pim-1 1 was the most potent inhibitor of pim-1 by outlining the crystal structure and it was also shown that tcs pim-1 1 had better inhibitory activity to pim-1 compared with pim-2 [1].

storage

Store at +4°C

References

[1]. cheney, i.w., et al., identification and structure-activity relationships of substituted pyridones as inhibitors of pim-1 kinase. bioorg med chem lett, 2007. 17(6): p. 1679-83.
[2]. cen, b., et al., the pim-1 protein kinase is an important regulator of met receptor tyrosine kinase levels and signaling. mol cell biol, 2014. 34(13): p. 2517-32.

3-Cyano-4-phenyl-6-(3-bromo-6-hydroxy)phenyl-2(1H)-pyridone Preparation Products And Raw materials

Raw materials

Preparation Products

3-Cyano-4-phenyl-6-(3-bromo-6-hydroxy)phenyl-2(1H)-pyridone Suppliers

Global( 68)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
career henan chemical co	+86-0371-86658258 15093356674;	factory@coreychem.com	China	29826	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	+86-021-61551413 +8618813727289	contact@trustwe.com	China	5738	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10523	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	trendseenbio@gmail.com	China	11681	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8474	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	57511	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131981	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	58
TargetMol Chemicals Inc.	58
Zhejiang J&C Biological Technology Co.,Limited	58
InvivoChem	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	58
Wuhan Topule Biopharmaceutical Co., Ltd	58
Aladdin Scientific	58
Amadis Chemical Company Limited	58

View Lastest Price from 3-Cyano-4-phenyl-6-(3-bromo-6-hydroxy)phenyl-2(1H)-pyridone manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2019-12-24	3-Cyano-4-phenyl-6-(3-bromo-6-hydroxy)phenyl-2(1H)-pyridone 491871-58-0	US $1.00 / g	1g	99%	20kg	Career Henan Chemical Co

3-Cyano-4-phenyl-6-(3-bromo-6-hydroxy)phenyl-2(1H)-pyridone
491871-58-0
US $1.00 / g
99%
Career Henan Chemical Co

3-Cyano-4-phenyl-6-(3-bromo-6-hydroxy)phenyl-2(1H)-pyridone Spectrum

3-Cyano-4-phenyl-6-(3-bromo-6-hydroxy)phenyl-2(1H)-pyridone(491871-58-0)¹HNMR

3-Cyano-4-phenyl-6-(3-bromo-6-hydroxy)phenyl-2(1H)-pyridone TCS PIM-1 1 SC 204330 6-(5-Bromo-2-hydroxyphenyl)-1,2-dihydro-2-oxo-4-phenyl-3-pyridinecarbonitrile TCS PIM-1 TCS PIM-1 1, >=98% SC 204330; TCS PIM 1-1 CS-1482 TCS PIM-1 1(sc-204330) 3-Pyridinecarbonitrile, 6-(5-bromo-2-hydroxyphenyl)-1,2-dihydro-2-oxo-4-phenyl- TCS PIM-1 1,scaffold,Pim,TCS PIM 1 1,Pim-1,pyridone,Inhibitor,Pim kinases,ATP-competitive,SC204330,SC-204330,inhibit,TCS PIM1 1 491871-58-0 Inhibitors