4,5-Dihydro-3-phenyl-5-isoxazoleaceticacid
- CAS No.
- 6501-72-0
- Chemical Name:
- 4,5-Dihydro-3-phenyl-5-isoxazoleaceticacid
- Synonyms
- GIT 27;VGX-127;CS-1488;VGX-1027;VGX-1027, >=98%;VGX-1027(GIT 27);VGX-1027, 6501-72-0;3-Phenyl-2-isoxazoline-5-acetic acid;2-Isoxazoline-5-acetic acid, 3-phenyl-;GIT27; GIT27; GIT-27; VGX1027; VGX 1027
- CBNumber:
- CB52518933
- Molecular Formula:
- C11H11NO3
- Molecular Weight:
- 205.21
- MDL Number:
- MFCD08696167
- MOL File:
- 6501-72-0.mol
Melting point | 157-158℃ |
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storage temp. | Sealed in dry,2-8°C |
solubility | Soluble in DMSO (up to 30 mg/ml). |
form | solid |
color | White |
Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
FDA UNII | AKT814N13R |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS08,GHS07 |
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Signal word | Danger | |||||||||
Hazard statements | H334-H302 | |||||||||
Precautionary statements | P264-P270-P301+P312-P330-P501-P261-P285-P304+P341-P342+P311-P501 | |||||||||
Hazard Codes | Xn | |||||||||
Risk Statements | 22-43 | |||||||||
Safety Statements | 36/37 | |||||||||
HS Code | 2934.99.4400 | |||||||||
NFPA 704 |
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4,5-Dihydro-3-phenyl-5-isoxazoleaceticacid price More Price(32)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
TCI Chemical | V0160 | VGX-1027 | 6501-72-0 | 10MG | $123 | 2024-03-01 | Buy |
TCI Chemical | V0160 | VGX-1027 | 6501-72-0 | 50MG | $370 | 2024-03-01 | Buy |
Cayman Chemical | 16293 | GIT 27 ≥98% | 6501-72-0 | 5mg | $62 | 2024-03-01 | Buy |
Cayman Chemical | 16293 | GIT 27 ≥98% | 6501-72-0 | 10mg | $109 | 2024-03-01 | Buy |
Cayman Chemical | 16293 | GIT 27 ≥98% | 6501-72-0 | 25mg | $239 | 2024-03-01 | Buy |
4,5-Dihydro-3-phenyl-5-isoxazoleaceticacid Chemical Properties,Uses,Production
Description
VGX-1027 (6501-72-0) is an immunomodulator that inhibits secretion of IL-1β, TNF-α, and IL-10 from murine macrophages stimulated with LPS and spares T cell function.1?Ameliorates the course of acute and chronic immunoinflammatory conditions such as carrageenan-induced pleurisy, LPS-induced lethality, and type II collagen-induced arthritis in mouse models.1?Prevents spontaneous and accelerated forms of autoimmune diabetes in a NOD mouse model.2?Modulates genes involved in LPS-induced Toll-like receptor 4 activation in a mouse Lupus model.3?Displays protective effects in particulate matter-induced acute lung injury by blocking TLR4 signaling.4
Uses
2-(3-Phenyl-4,5-dihydroisoxazol-5-yl)acetic Acid reduces the secretion of IL-1β, TNF-α and IL-10 from purified murine macrophages but not of T cells; and reduces the activation of NF-κB and p38 MAP kinase pathways along with up-regulation of ERK pathways. 2-(3-Phenyl-4,5-dihydroisoxazol-5-yl)acetic Acid inhibits proliferation of enterobacterial antigen-reactive CD4+CD25- T cells in vitro .
storage
Store at +4°C
References
1) Stojanovic?et al.?(2007),?In vitro, ex vivo and in vivo immunopharmacological activities of the isooxazoline compound VGX-1027: modulation of cytokine synthesis and prevention of both organ-specific and systemic autoimmune diseases in murine models; Clin. Immunol.,?123?311 2) Stosic-Grujisic?et al.?(2007),?A potent immunomodulatory compound, (S,R)-3-Phenyl-4,5-dihydro-5-isoxazole acetic acid, prevents spontaneous and accelerated forms of autoimmune diabetes in NOD mice and inhibits the immunoinflammatory diabetes induced by multiple low doses of streptozotocin in CBA/H mice; J. Pharmacol. Exp. Ther.,?320?1038 3) Fagone?et al.?(2014),?VGX-1027 modulates genes involved in lipopolysaccharide-induced Toll-like receptor 4 activation and in a murine model of systemic lupus erythematosus; Immunology,?142?594 4) Xu?et al.?(2019),?Protective effects of VGX-1027 in PM2.5-induced airway inflammation and bronchial hyperresponsiveness; Eur. J, Pharmacol.,?842?373
4,5-Dihydro-3-phenyl-5-isoxazoleaceticacid Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30256 | 58 |
Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
Nanjing Doge Biomedical Technology Co., Ltd | +86-25-58227606 +86-15305155328 | sales@dogechemical.com | China | 4128 | 58 |
Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |