ChemicalBook >> CAS DataBase List >>4,5-Dihydro-3-phenyl-5-isoxazoleaceticacid

4,5-Dihydro-3-phenyl-5-isoxazoleaceticacid

CAS No.
6501-72-0
Chemical Name:
4,5-Dihydro-3-phenyl-5-isoxazoleaceticacid
Synonyms
GIT 27;VGX-127;CS-1488;VGX-1027;VGX-1027, >=98%;VGX-1027(GIT 27);VGX-1027, 6501-72-0;3-Phenyl-2-isoxazoline-5-acetic acid;2-Isoxazoline-5-acetic acid, 3-phenyl-;GIT27; GIT27; GIT-27; VGX1027; VGX 1027
CBNumber:
CB52518933
Molecular Formula:
C11H11NO3
Molecular Weight:
205.21
MDL Number:
MFCD08696167
MOL File:
6501-72-0.mol
Last updated:2023-06-30 15:45:59

4,5-Dihydro-3-phenyl-5-isoxazoleaceticacid Properties

Melting point 157-158℃
storage temp. Sealed in dry,2-8°C
solubility Soluble in DMSO (up to 30 mg/ml).
form solid
color White
Stability Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
FDA UNII AKT814N13R

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS08,GHS07
Signal word  Danger
Hazard statements  H334-H302
Precautionary statements  P264-P270-P301+P312-P330-P501-P261-P285-P304+P341-P342+P311-P501
Hazard Codes  Xn
Risk Statements  22-43
Safety Statements  36/37
HS Code  2934.99.4400
NFPA 704
0
2 0

4,5-Dihydro-3-phenyl-5-isoxazoleaceticacid price More Price(32)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical V0160 VGX-1027 6501-72-0 10MG $123 2024-03-01 Buy
TCI Chemical V0160 VGX-1027 6501-72-0 50MG $370 2024-03-01 Buy
Cayman Chemical 16293 GIT 27 ≥98% 6501-72-0 5mg $62 2024-03-01 Buy
Cayman Chemical 16293 GIT 27 ≥98% 6501-72-0 10mg $109 2024-03-01 Buy
Cayman Chemical 16293 GIT 27 ≥98% 6501-72-0 25mg $239 2024-03-01 Buy
Product number Packaging Price Buy
V0160 10MG $123 Buy
V0160 50MG $370 Buy
16293 5mg $62 Buy
16293 10mg $109 Buy
16293 25mg $239 Buy

4,5-Dihydro-3-phenyl-5-isoxazoleaceticacid Chemical Properties,Uses,Production

Description

VGX-1027 (6501-72-0) is an immunomodulator that inhibits secretion of IL-1β, TNF-α, and IL-10 from murine macrophages stimulated with LPS and spares T cell function.1?Ameliorates the course of acute and chronic immunoinflammatory conditions such as carrageenan-induced pleurisy, LPS-induced lethality, and type II collagen-induced arthritis in mouse models.1?Prevents spontaneous and accelerated forms of autoimmune diabetes in a NOD mouse model.2?Modulates genes involved in LPS-induced Toll-like receptor 4 activation in a mouse Lupus model.3?Displays protective effects in particulate matter-induced acute lung injury by blocking TLR4 signaling.4

Uses

2-(3-Phenyl-4,5-dihydroisoxazol-5-yl)acetic Acid reduces the secretion of IL-1β, TNF-α and IL-10 from purified murine macrophages but not of T cells; and reduces the activation of NF-κB and p38 MAP kinase pathways along with up-regulation of ERK pathways. 2-(3-Phenyl-4,5-dihydroisoxazol-5-yl)acetic Acid inhibits proliferation of enterobacterial antigen-reactive CD4+CD25- T cells in vitro .

storage

Store at +4°C

References

1) Stojanovic?et al.?(2007),?In vitro, ex vivo and in vivo immunopharmacological activities of the isooxazoline compound VGX-1027: modulation of cytokine synthesis and prevention of both organ-specific and systemic autoimmune diseases in murine models; Clin. Immunol.,?123?311 2) Stosic-Grujisic?et al.?(2007),?A potent immunomodulatory compound, (S,R)-3-Phenyl-4,5-dihydro-5-isoxazole acetic acid, prevents spontaneous and accelerated forms of autoimmune diabetes in NOD mice and inhibits the immunoinflammatory diabetes induced by multiple low doses of streptozotocin in CBA/H mice; J. Pharmacol. Exp. Ther.,?320?1038 3) Fagone?et al.?(2014),?VGX-1027 modulates genes involved in lipopolysaccharide-induced Toll-like receptor 4 activation and in a murine model of systemic lupus erythematosus; Immunology,?142?594 4) Xu?et al.?(2019),?Protective effects of VGX-1027 in PM2.5-induced airway inflammation and bronchial hyperresponsiveness; Eur. J, Pharmacol.,?842?373

4,5-Dihydro-3-phenyl-5-isoxazoleaceticacid Preparation Products And Raw materials

Raw materials

Preparation Products

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4,5-Dihydro-3-phenyl-5-isoxazoleaceticacid GIT 27 VGX-1027 2-(3-PHENYL-4,5-DIHYDROISOXAZOL-5-YL)ACETIC ACID 3-Phenyl-2-isoxazoline-5-acetic acid VGX 1027 3-Phenyl-2-isoxazoline-5-acetic acid (S,R)-3-Phenyl-4,5-dihydro-5-isoxasole acetic acid 2-Isoxazoline-5-acetic acid, 3-phenyl- 5-Isoxazoleacetic acid, 4,5-dihydro-3-phenyl- VGX-1027, >=98% VGX-127 VGX-1027, 6501-72-0 (3-Phenyl-4,5-dihydro-1,2-oxazol-5-yl)acetic acid 2-(3-phenyl-4,5-dihydro-1,2-oxazol-5-yl)acetic acid GIT27; GIT27; GIT-27; VGX1027; VGX 1027 VGX-1027(GIT 27) CS-1488 VGX-1027,Tumor Necrosis Factor Receptor,inhibit,Interleukin Related,GIT27,GIT-27,Inhibitor,TNF Receptor,TNFR 6501-72-0 Inhibitors