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Atopaxar

CAS No.
751475-53-3
Chemical Name:
Atopaxar
Synonyms
E555;CS-666;E 5555;Atopaxa;Atopaxar;ER 172594-00;Atopaxar (E 5555);(943239-67-6) atopaxar;Benzoicacid,4-hydroxy-3,6-dimethoxy-;1-(3-(tert-Butyl)-4-methoxy-5-morpholinophenyl)-2-(5,6-diethoxy-7-fluoro-1-iminoisoindolin-2-yl)ethanone
CBNumber:
CB52521159
Molecular Formula:
C29H38FN3O5
Molecular Weight:
527.63
MDL Number:
MFCD20040417
MOL File:
751475-53-3.mol
MSDS File:
SDS
Last updated:2023-09-04 15:51:00

Atopaxar Properties

Boiling point 671.0±65.0 °C(Predicted)
Density 1.22
storage temp. Store at -20°C
solubility DMSO : 250 mg/mL (473.82 mM; Need ultrasonic)
pka 7.43±0.20(Predicted)
FDA UNII HTI275SD2D

Atopaxar price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML3064 Atopaxar hydrobromide ≥98% (HPLC) 751475-53-3 5MG $179 2024-03-01 Buy
Sigma-Aldrich SML3064 Atopaxar hydrobromide ≥98% (HPLC) 751475-53-3 25MG $576 2024-03-01 Buy
DC Chemicals DC9198 Atopaxar(E5555) >98% 751475-53-3 100mg $750 2021-12-16 Buy
Product number Packaging Price Buy
SML3064 5MG $179 Buy
SML3064 25MG $576 Buy
DC9198 100mg $750 Buy

Atopaxar Chemical Properties,Uses,Production

Definition

ChEBI: Atopaxar is an aromatic ketone.

Biological Activity

Atopaxar (E5555) is a potent, orally active, selective, reversible thrombin receptor protease-activated receptor-1 (PAR-1) antagonist. It can be used in the study of atherothrombotic diseases and interferes with platelet signaling..

in vitro

Atopaxar inhibits haTRAP (high-affinity thrombin receptor activating peptide) binding to PAR-1 on human platelet membranes in a concentration-dependent manner, with an IC 50 of 0.019 μM. < br/> Atopaxar inhibits human platelet aggregation induced by thrombin or TRAP in a concentration-dependent manner.
Atopaxar does not inhibit PRP (platelet-rich plasma) aggregation induced by ADP, U46619, collagen, and PAR-4ap, up to a concentration of 20 μM.

in vivo

Atopaxar (30-100 mg/kg; po) causes a dose-dependent prolongation of the time to occlusion of the femoral artery in photochemically-induced thrombosis (PIT) guinea pigs model.
Atopaxar does not prolong bleeding time in guinea pigs at the highest tested dosage of 1000 mg/kg.

< td class="col1 fwb"> Result:
Animal Model: Guinea pigs, PIT model
Dosage: Oral administration
Administration: 10 mg/kg, 30 mg/kg, 100 mg/kg
Prolonged the time to occlusion by 1.8-fold and 2.4-fold at 30 mg/kg and 100 mg/kg, respectively, compared with controls.

target

PAR-1

Atopaxar Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 45)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795 ivan@atkchemical.com China 32480 60
Hubei xin bonus chemical co. LTD
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CONIER CHEM AND PHARMA LIMITED
+8618523575427 sales@conier.com China 47465 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
InvivoChem
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Wuhan Topule Biopharmaceutical Co., Ltd
+8618327326525 masar@topule.com China 8475 58
Jilin Chinese Academy of Sciences-yanshen Technology
+undefined18143011203 info@chemextension.com China 42057 58
Aladdin Scientific
+1-833-552-7181 sales@aladdinsci.com United States 35748 58
Amadis Chemical Company Limited
571-89925085 sales@amadischem.com China 132020 58
Shanghai Luofa Biochemical Technology Co., Ltd. 021-51111890 15317326293 sales@molnova.com China 4196 58

Atopaxar Spectrum

ER 172594-00 2-(5,6-Diethoxy-7-fluoro-1,3-dihydro-1-imino-2H-isoindol-2-yl)-1-[3-(1,1-dimethylethyl)-4-methoxy-5-(4-morpholinyl)phenyl]ethanone Atopaxar E 5555 1-(3-tert-butyl-4-Methoxy-5-Morpholino-phenyl)-2-(5,6-diethoxy-7-fluoro-1-iMino-1,3-dihydro-isoindol-2-yl)-ethanone E555 1-(3-(tert-Butyl)-4-methoxy-5-morpholinophenyl)-2-(5,6-diethoxy-7-fluoro-1-iminoisoindolin-2-yl)ethanone (943239-67-6) atopaxar Atopaxar (E 5555) CS-666 Atopaxa Ethanone, 2-(5,6-diethoxy-7-fluoro-1,3-dihydro-1-imino-2H-isoindol-2-yl)-1-[3-(1,1-dimethylethyl)-4-methoxy-5-(4-morpholinyl)phenyl]- Benzoicacid,4-hydroxy-3,6-dimethoxy- E5555,platelets,Atopaxar,receptor-1,signaling,PAR-1,inhibit,E-5555,Inhibitor,receptor,Protease Activated Receptor (PAR),protease-activated,atherothrombotic,E 5555,thrombin,Thrombin receptors 751475-53-3 C29H38FN3O5 Inhibitors