Atopaxar
- CAS No.
- 751475-53-3
- Chemical Name:
- Atopaxar
- Synonyms
- E555;CS-666;E 5555;Atopaxa;Atopaxar;ER 172594-00;Atopaxar (E 5555);(943239-67-6) atopaxar;Benzoicacid,4-hydroxy-3,6-dimethoxy-;1-(3-(tert-Butyl)-4-methoxy-5-morpholinophenyl)-2-(5,6-diethoxy-7-fluoro-1-iminoisoindolin-2-yl)ethanone
- CBNumber:
- CB52521159
- Molecular Formula:
- C29H38FN3O5
- Molecular Weight:
- 527.63
- MDL Number:
- MFCD20040417
- MOL File:
- 751475-53-3.mol
- MSDS File:
- SDS
Boiling point | 671.0±65.0 °C(Predicted) |
---|---|
Density | 1.22 |
storage temp. | Store at -20°C |
solubility | DMSO : 250 mg/mL (473.82 mM; Need ultrasonic) |
pka | 7.43±0.20(Predicted) |
FDA UNII | HTI275SD2D |
Atopaxar price
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | SML3064 | Atopaxar hydrobromide ≥98% (HPLC) | 751475-53-3 | 5MG | $179 | 2024-03-01 | Buy |
Sigma-Aldrich | SML3064 | Atopaxar hydrobromide ≥98% (HPLC) | 751475-53-3 | 25MG | $576 | 2024-03-01 | Buy |
DC Chemicals | DC9198 | Atopaxar(E5555) >98% | 751475-53-3 | 100mg | $750 | 2021-12-16 | Buy |
Atopaxar Chemical Properties,Uses,Production
Definition
ChEBI: Atopaxar is an aromatic ketone.
Biological Activity
Atopaxar (E5555) is a potent, orally active, selective, reversible thrombin receptor protease-activated receptor-1 (PAR-1) antagonist. It can be used in the study of atherothrombotic diseases and interferes with platelet signaling..
in vitro
Atopaxar inhibits haTRAP (high-affinity thrombin receptor activating peptide) binding to PAR-1 on human platelet membranes in a concentration-dependent manner, with an IC 50 of 0.019 μM. < br/> Atopaxar inhibits human platelet aggregation induced by thrombin or TRAP in a concentration-dependent manner.
Atopaxar does not inhibit PRP (platelet-rich plasma) aggregation induced by ADP, U46619, collagen, and PAR-4ap, up to a concentration of 20 μM.
in vivo
Atopaxar (30-100 mg/kg; po) causes a dose-dependent prolongation of the time to occlusion of the femoral artery in photochemically-induced thrombosis (PIT) guinea pigs model.
Atopaxar does not prolong bleeding time in guinea pigs at the highest tested dosage of 1000 mg/kg.
Animal Model: | Guinea pigs, PIT model |
Dosage: | Oral administration |
Administration: | 10 mg/kg, 30 mg/kg, 100 mg/kg |
Prolonged the time to occlusion by 1.8-fold and 2.4-fold at 30 mg/kg and 100 mg/kg, respectively, compared with controls. |
target
PAR-1
Atopaxar Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8475 | 58 |
Jilin Chinese Academy of Sciences-yanshen Technology | +undefined18143011203 | info@chemextension.com | China | 42057 | 58 |
Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 35748 | 58 |
Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 132020 | 58 |
Shanghai Luofa Biochemical Technology Co., Ltd. | 021-51111890 15317326293 | sales@molnova.com | China | 4196 | 58 |