Betamethasone 21-phosphate disodium
- CAS No.
- 151-73-5
- Chemical Name:
- Betamethasone 21-phosphate disodium
- Synonyms
- BETAMETHASONE SODIUM PHOSPHATE;BETAMETHASONE 21-DISODIUM PHOSPHATE;Durabetason;bentelan;betnesol;Celestan;Bentalan;NSC 90616;Vista-Methasone;Betamethasone 21-pho
- CBNumber:
- CB5252688
- Molecular Formula:
- C22H28FNa2O8P
- Molecular Weight:
- 516.4
- MDL Number:
- MFCD00200361
- MOL File:
- 151-73-5.mol
| Melting point | 206-211°C |
|---|---|
| alpha | +98.0～+104.0°(D/20℃)(c=1,H2O) (calculated on the dehydrous basis) |
| storage temp. | room temp |
| solubility | Freely soluble in water, slightly soluble in ethanol (96 per cent), practically insoluble in methylene chloride. |
| color | White to Off-White |
| PH | 7.5～9.0(5g/l, 25℃) |
| Merck | 14,1180 |
| Stability | Hygroscopic |
| InChIKey | PLCQGRYPOISRTQ-LWCNAHDDSA-L |
| SMILES | [C@@]12([H])C[C@H](C)[C@](O)(C(=O)COP([O-])([O-])=O)[C@@]1(C)C[C@H](O)[C@]1(F)[C@@]3(C)C=CC(=O)C=C3CC[C@@]21[H].[Na+].[Na+] |&1:0,3,5,15,18,20,22,32,r| |
| FDA UNII | 7BK02SCL3W |
| EPA Substance Registry System | .beta.-Methasone disodium phosphate (151-73-5) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H360FD-H373 | |||||||||
| Precautionary statements | P202-P260-P264-P270-P301+P312-P308+P313 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22 | |||||||||
| Safety Statements | 36 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | TU4056500 | |||||||||
| HS Code | 29372290 | |||||||||
| Toxicity | LD50 orl-rat: 1877 mg/kg DRUGAY -,1075,90 | |||||||||
| NFPA 704 |
|
Betamethasone 21-phosphate disodium price More Price(21)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | B7652 | Betamethasone 21-phosphate disodium ≥97% | 151-73-5 | 1g | $372 | 2024-03-01 | Buy |
| Sigma-Aldrich | 1068004 | Betamethasone sodium phosphate United States Pharmacopeia (USP) Reference Standard | 151-73-5 | 500mg | $436 | 2024-03-01 | Buy |
| TCI Chemical | B4110 | Betamethasone 21-Phosphate Disodium Salt >98.0%(HPLC)(T) | 151-73-5 | 1g | $223 | 2024-03-01 | Buy |
| Sigma-Aldrich | B7652 | Betamethasone 21-phosphate disodium ≥97% | 151-73-5 | 250mg | $62 | 2024-03-01 | Buy |
| Sigma-Aldrich | B1045000 | Betamethasone sodium phosphate European Pharmacopoeia (EP) Reference Standard | 151-73-5 | b1045000 | $220 | 2024-03-01 | Buy |
Betamethasone 21-phosphate disodium Chemical Properties,Uses,Production
Indications and Usage
Betamethasone Sodium Phosphate, also called Bentelan, Betnesol, betamethasone phosphate, and celestone phosphate, is an adrenal cortex hormone, an isomer of dexamethasone with the same effects as prednisolone and dexamethasone.
It is mainly used against inflammation and allergies. Its effects are the same as those of dexamethasone, and its anti-inflammatory effects are stronger than dexamethasone, prednisone, and cortisone, with fewer side effects. It is used to treat active rheumatism, rheumatoid arthritis, lupus erythematosus, severe bronchial asthma, severe dermatitis, acute leukemia, allergic dermatitis, eczema, neurodermatitis, seborrheic dermatitis, pruritis, and comprehensively treat some infections.
Mechanisms of Action
Betamethasone sodium phosphate has pharmacological effects in treating inflammation, rheumatism, allergies, and immunosuppressive conditions. Its anti-inflammatory effects are stronger than those of dexamethasone, triamcinolone, and hydrocortisone. It can reduce and prevent tissue response to inflammation, partly eliminating non-infectious inflammation caused by fever, redness, and swelling, thereby reducing the presence of swelling. The anti-inflammatory effects of 0.3 mg of betamethasone sodium phosphate are comparable to those of 0.75 mg of dexamethasone, 5 mg of prednisone, or 25 mg of cortisone. Its sodium retention effects are more than a hundred times those of cortisone. In case of primary adrenal hypofunction, together with corticosteroids, it can be used to replace treatment or prevention, or inhibit of cellular immune response, delay allergic reaction, and reduce the extension of the primary immune response, suitable for low renin and low aldosterone syndrome and orthodontic hypotension caused by autonomic neuropathy.
Contraindications
Not for use by those with a history of serious mental illness, active duodenum, gastric ulcers, recent gastrointestinal anastomosis, serious osteoporosis, pronounced diabetes, or serious high blood pressure, viruses which cannot be treated by antibiotics, bacterial of fungal infection, thrombophlebitis, or infectious skin diseases such as impetigo, tinea corporis, or tinea cruris.
Category
Toxic
Toxicity level
Medium
Acute toxicity
Oral administration - mice LD50: >4500 mg/kg
Flammability
Flammable; produces toxic fluoride fumes
Storage and transport
Store in a cool, ventilated, and dry place
Extinguishing agents
Dry powder, foam, sand, carbon dioxide, mist
Chemical Properties
White or almost white powder, very hygroscopic.
Uses
Betamethasone 21-Phosphate Disodium Salt (Dexamethasone Sodium Phosphate EP Impurity B) is a Betamethasone derivative. It is a glucocorticoid steroid with anti-inflammatory and immunosuppressive properties which can be used in treatment of asthma and itching.
Uses
An anti-inflammatory agent
Uses
Nasal, Ophthalmic, Oral, Parenteral
Uses
antiinflammatory, glucocorticoid
Definition
ChEBI: An organic sodium salt that is the disodium salt of betamethasone phosphate.
brand name
Celestone (Schering).
Biochem/physiol Actions
Betamethasone is used to treat neonatal respiratory distress syndrome, and psoriasis.
Safety Profile
Moderately toxic by ingestion andother routes. An experimental teratogen. Otherexperimental reproductive effects. When heated todecomposition it emits toxic fumes of F??, POx and Na2O.
Betamethasone 21-phosphate disodium Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nanjing Shizhou Biotechnology Co., Ltd | +86-15850508050 +86-15850508050 | sean.lv@synzest.com | China | 323 | 58 |
| Shaanxi TNJONE Pharmaceutical Co., Ltd | +8618740459177 | sarah@tnjone.com | China | 893 | 58 |
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12456 | 58 |
| Henan Bao Enluo International TradeCo.，LTD | +86-17331933971 +86-17331933971 | deasea125996@gmail.com | China | 2503 | 58 |
| Wuhan Haorong Biotechnology Co.,ltd | +8618565342920 | sales@chembj.net | China | 269 | 58 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 15928 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21691 | 55 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3012 | 60 |
| Hubei XinRunde Chemical Co., Ltd. | +8615102730682 | bruce@xrdchem.cn | CHINA | 566 | 55 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
View Lastest Price from Betamethasone 21-phosphate disodium manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-24 | Betamethasone 21-phosphate disodium/Durabetason
151-73-5
|
US $0.00-0.00 / KG | 1KG | 99% | 500 | Wuhan Haorong Biotechnology Co.,Ltd | |
 |
2024-04-22 | Betamethasone Sodium Phosphate
151-73-5
|
US $0.00 / kg | 1kg | 99% | 20tons | Shaanxi TNJONE Pharmaceutical Co., Ltd | |
 |
2024-03-16 | Betamethasone 21-phosphate disodium
151-73-5
|
US $0.00 / KG | 100g | 98%+ | 100kg | WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD |
-
- Betamethasone 21-phosphate disodium/Durabetason
151-73-5
- US $0.00-0.00 / KG
- 99%
- Wuhan Haorong Biotechnology Co.,Ltd
-
- Betamethasone Sodium Phosphate
151-73-5
- US $0.00 / kg
- 99%
- Shaanxi TNJONE Pharmaceutical Co., Ltd
-
- Betamethasone 21-phosphate disodium
151-73-5
- US $0.00 / KG
- 98%+
- WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
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