ChemicalBook >> CAS DataBase List >>GSK269962A
GSK269962A
- CAS No.
- 850664-21-0
- Chemical Name:
- GSK269962A
- Synonyms
- CS-1126;GSK 269962;GSK269962B;GSK-269962 95%;GSK269962A(GSK269962);GSK269962 (GSK269962A);GSK269962A/GSK 269962A;ROCK inhibitor GS269962A;ROCK inhibitor GSK269962A;GSK269962A ISO 9001：2015 REACH
- CBNumber:
- CB52546776
- Molecular Formula:
- C29H30N8O5
- Molecular Weight:
- 570.6
- MDL Number:
- MFCD09970310
- MOL File:
- 850664-21-0.mol
Last updated:2023-06-30 15:45:59
| Melting point | 125 - 127°C |
|---|---|
| Density | 1.45 |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 13.19±0.70(Predicted) |
| color | Off-White |
| FDA UNII | F89KMM7TE2 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| NFPA 704 |
|
GSK269962A price More Price(27)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 19180 | GSK269962 ≥95% | 850664-21-0 | 1mg | $37 | 2024-03-01 | Buy |
| Cayman Chemical | 19180 | GSK269962 ≥95% | 850664-21-0 | 5mg | $161 | 2024-03-01 | Buy |
| Cayman Chemical | 19180 | GSK269962 ≥95% | 850664-21-0 | 10mg | $283 | 2024-03-01 | Buy |
| Cayman Chemical | 19180 | GSK269962 ≥95% | 850664-21-0 | 25mg | $618 | 2024-03-01 | Buy |
| Tocris | 4009 | GSK269962 ≥99%(HPLC) | 850664-21-0 | 10 | $292 | 2021-12-16 | Buy |
GSK269962A Chemical Properties,Uses,Production
Description
Two Rho-associated kinases (ROCKS), ROCK1 and ROCK2, act downstream of the G protein Rho to regulate cytoskeletal stability. The ROCKs play important roles in diverse cellular functions including cell adhesion and proliferation, smooth muscle contraction, and stem cell renewal. GSK269962 is a selective ROCK inhibitor with IC50 values of 1.6 and 6 nM for ROCK1 and ROCK2, respectively. It displays greater than 30-fold selectivity for ROCK against a panel of serine/threonine kinases. GSK269962 has been shown to block the generation of inflammatory cytokines in lipopolysaccharide-stimulated monocytes and to induce vasorelaxation in preconstricted rat aorta (IC50 = 35 nM). Oral administration of 1-30 mg/kg GSK269962 can dose-dependently lower blood pressure in spontaneously hypertensive rats.
Uses
GSK 269962 is a potent and selective Rho kinase (ROCK) inhibitor.
storage
Store at +4°C
GSK269962A Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 85)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 9358 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29271 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Hebei Duling International Trade Co. LTD | +8618032673083 | sales05@hbduling.cn | China | 15745 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
View Lastest Price from GSK269962A manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-17 | GSK269962A
850664-21-0
|
US $1.10 / g | 1g | 99.0% min | 100 tons min | Shaanxi Dideu Medichem Co. Ltd | |
 |
2021-10-14 | GSK269962A
850664-21-0
|
US $1.10 / g | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited | |
![N-(3-{[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-1H-imidazo[4,5-c] pyridin-6-yl]oxy}phenyl)-4-[2-(4-morpholinyl)ethoxy]benzamide pictures](https://img.chemicalbook.com/ProductImageEN/2020-1/Small/35a3e43e-66d0-4062-a2d4-04b7bdec5403.png) |
2020-01-02 | N-(3-{[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-1H-imidazo[4,5-c] pyridin-6-yl]oxy}phenyl)-4-[2-(4-morpholinyl)ethoxy]benzamide
850664-21-0
|
US $1.00 / KG | 1KG | Min98% HPLC | g/kg/ton | Career Henan Chemical Co |
-
- GSK269962A
850664-21-0
- US $1.10 / g
- 99.0% min
- Shaanxi Dideu Medichem Co. Ltd
-
- GSK269962A
850664-21-0
- US $1.10 / g
- 99.00%
- Dideu Industries Group Limited
-
- N-(3-{[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-1H-imidazo[4,5-c] pyridin-6-yl]oxy}phenyl)-4-[2-(4-morpholinyl)ethoxy]benzamide
850664-21-0
- US $1.00 / KG
- Min98% HPLC
- Career Henan Chemical Co
GSK 269962
N-[3-[[2-(4-Aminofurazan-3-yl)-1-ethyl-1H-imidazo[4,5-c]pyridin-6-yl]oxy]phenyl]-4-[[2-(4-morpholinyl)ethyl]oxy]benzamide
GSK269962A(GSK269962)
N-(3-((2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-1H-imidazo[4,5-c]pyridin-6-yl)oxy)phenyl)-4-(2-morpholinoethoxy)benzamide
GSK269962A ISO 9001：2015 REACH
GSK269962 (GSK269962A)
ROCK inhibitor GSK269962A
GSK-269962 95%
GSK269962B
GSK 269962A;GSK-269962A;GSK269962;GSK 269962;GSK-269962
ROCK inhibitor GS269962A
N-[3-[[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-1H-imidazo[4,5-c]pyridin-6-yl]oxy]phenyl]-4-[2-(4-morpholinyl)ethoxy]benzamide
CS-1126
anti-inflammatory,ROCK,pressure,blood,antihypertensive,Rho-associated protein kinase,Inhibitor,GSK-269962,Rho-associated kinase,ROK,ROCK2,inhibit,GSK-269962A,GSK269962,vasodilatory,Rho-kinase,GSK269962A,ROCK1,cardiovascular
GSK269962A/GSK 269962A
850664-21-0