ChemicalBook >> CAS DataBase List >>Refametinib
Refametinib
- CAS No.
- 923032-37-5
- Chemical Name:
- Refametinib
- Synonyms
- RDEA119;CS-2434;Lorlatinib;BAY-869766;RefaMetinib;BAY 8697661;RDEA119 USP/EP/BP;REFAMETINIB(RDEA119);RDEA-119 (BAY-869766);Acrylamide Impurity 13
- CBNumber:
- CB52561494
- Molecular Formula:
- C19H20F3IN2O5S
- Molecular Weight:
- 572.34
- MDL Number:
- MFCD18633256
- MOL File:
- 923032-37-5.mol
- MSDS File:
- SDS
Last updated:2023-05-21 10:59:17
| Boiling point | 566.9±60.0 °C(Predicted) |
|---|---|
| Density | 1.82±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | insoluble in H2O; ≥151.8 mg/mL in DMSO; ≥90.2 mg/mL in EtOH |
| form | Powder |
| pka | 15.54±0.20(Predicted) |
| NCI Dictionary of Cancer Terms | lorlatinib |
| FDA UNII | JPX07AFM0N |
| NCI Drug Dictionary | lorlatinib |
| ATC code | L01ED05 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|---|---|
| Signal word | Danger |
| Hazard statements | H372-H361 |
| Precautionary statements | P201-P202-P281-P308+P313-P405-P501-P260-P264-P270-P314-P501 |
| HS Code | 2935909099 |
Refametinib price More Price(27)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 16997 | Refametinib ≥95% | 923032-37-5 | 1mg | $38 | 2024-03-01 | Buy |
| Cayman Chemical | 16997 | Refametinib ≥95% | 923032-37-5 | 5mg | $111 | 2024-03-01 | Buy |
| Cayman Chemical | 16997 | Refametinib ≥95% | 923032-37-5 | 10mg | $166 | 2024-03-01 | Buy |
| Cayman Chemical | 16997 | Refametinib ≥95% | 923032-37-5 | 50mg | $547 | 2024-03-01 | Buy |
| Usbiological | 464562 | Refametinib | 923032-37-5 | 1mg | $312 | 2021-12-16 | Buy |
Refametinib Chemical Properties,Uses,Production
Description
Lorlatinib (PF-06463922, Pfizer Oncology, Groton, CT, USA) is an oral TKI that targets both ALK and ROS1 with high affinity and good CNS penetration [91].
Uses
Refametinib (RDEA119, Bay 86-9766) is a potent, ATP non-competitive and highly selective inhibitor of MEK1 and MEK2. Potent MEK inhibitor.
Clinical Use
Lorlatinib is the sole third-generation ALK inhibitor at this time; it is approved for ALK-positive NSCLC patients who progressed on at least two ALK inhibitors with one being crizotinib or who progressed on alectinib or ceritinib if either is used in the frontline setting.
target
MEK1
References
[1] iverson c, larson g, lai c, et al. rdea119/bay 869766: a potent, selective, allosteric inhibitor of mek1/2 for the treatment of cancer. cancer research, 2009, 69(17): 6839-6847.
Refametinib Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 104)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| Chengdu Feibo Pharm Technology Co., Ltd | 15982321820 | abby@arkpharm.com | CHINA | 3279 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29271 | 58 |
| Baoji Guokang Bio-Technology Co., Ltd. | 0917-3909592 13892490616 | gksales1@gk-bio.com | China | 9339 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Hebei Duling International Trade Co. LTD | +8618032673083 | sales05@hbduling.cn | China | 15745 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
View Lastest Price from Refametinib manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-03-24 | RDEA119
923032-37-5
|
US $100.00 / kg | 1kg | 99% | 20 tons | Hebei Duling International Trade Co. LTD | |
 |
2021-07-13 | Refametinib
923032-37-5
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | |
 |
2021-07-10 | Refametinib
923032-37-5
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
-
- RDEA119
923032-37-5
- US $100.00 / kg
- 99%
- Hebei Duling International Trade Co. LTD
-
- Refametinib
923032-37-5
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- Refametinib
923032-37-5
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
923032-37-5(Refametinib )Related Search:
RDEA119
BAY-869766
RefaMetinib
RDEA-119 (BAY-869766)
BAY 8697661
RefaMetinib/BAY 8697661
N-[3,4-Difluoro-2-[(2-fluoro-4-iodophenyl)amino]-6-methoxyphenyl]-1-[(2S)-2,3-dihydroxypropyl]cyclopropanesulfonamide
(S)-N-(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-6-methoxyphenyl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide
REFAMETINIB(RDEA119)
Lorlatinib
BAY 869766;BAY 86-97661;RDEA119
Cyclopropanesulfonamide, N-[3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-6-methoxyphenyl]-1-[(2S)-2,3-dihydroxypropyl]-
RDEA119 USP/EP/BP
Refametinib S enantiomer
CS-2434
BAY 869766; BAY 86-9766
Refametinib (BAY86-9766)
N-[3,4-difluoro-2-(2-fluoro-4-iodoanilino)-6-methoxyphenyl]-1-[(2s)-2,3-dihydroxypropyl]cyclopropane-1-sulfonamide
Acrylamide Impurity 13
923032-37-5
C19H20F3IN2O5S
Inhibitors