Infigratinib
- CAS No.
- 872511-34-7
- Chemical Name:
- Infigratinib
- Synonyms
- BGJ-398;Infligratinib;BGJ;CS-218;BGJ 398;NVP-BGJ398;Infigratinib;Transcrocetinate;NVP-BGJ398, >=98%;BGJ398 (NVP-BGJ398)
- CBNumber:
- CB52589643
- Molecular Formula:
- C26H31Cl2N7O3
- Molecular Weight:
- 560.48
- MDL Number:
- MFCD22123241
- MOL File:
- 872511-34-7.mol
- MSDS File:
- SDS
| Melting point | >211°C (dec.) |
|---|---|
| Boiling point | 747.9±60.0 °C(Predicted) |
| Density | 1.354 |
| storage temp. | -20°C |
| solubility | Soluble in DMSO (up to 5 mg/ml) |
| form | White solid. |
| pka | 11.02±0.70(Predicted) |
| color | White |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months. |
| FDA UNII | A4055ME1VK |
Infigratinib price More Price(35)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 19157 | BGJ398 ≥98% | 872511-34-7 | 1mg | $62 | 2024-03-01 | Buy |
| Cayman Chemical | 19157 | BGJ398 ≥98% | 872511-34-7 | 5mg | $120 | 2024-03-01 | Buy |
| Cayman Chemical | 19157 | BGJ398 ≥98% | 872511-34-7 | 10mg | $191 | 2024-03-01 | Buy |
| Cayman Chemical | 19157 | BGJ398 ≥98% | 872511-34-7 | 25mg | $313 | 2024-03-01 | Buy |
| TRC | B367000 | BGJ398 | 872511-34-7 | 200mg | $425 | 2021-12-16 | Buy |
Infigratinib Chemical Properties,Uses,Production
Uses
BGJ 398 is a potent and selective inhibitor of the fibroblast growth factor receptor family of receptor tyrosine kinase.
Description
NVP-BGJ398 (872511-34-7) is a potent and selective pan-FGFR inhibitor (IC50?= 0.9nM, 1.4 nM, 1.0 nM, and 60 nM for FGFR1,2,3,4 respectively).1? It has also been used in a mouse model of Achondroplasia (most common form of dwarfism) to correct pathological hallmarks of this condition.
Uses
BGJ 398 is a potent and selective inhibitor of the fibroblast growth factor receptor family of receptor tyrosine kinase.
Definition
ChEBI: BGJ-398 is a member of the class of phenylureas that is urea in which a hydrogen attached to one of the nitrogens is replaced by a 2,6-dichloro-3,5-dimethoxyphenyl group, while the hydrogens attached to the other nitrogen are replaced by a methyl group and a 6-{[4-(4-ethylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl group. It is a potent and selective fibroblast growth factor receptor inhibitor. It has a role as a fibroblast growth factor receptor antagonist and an antineoplastic agent. It is an aminopyrimidine, a N-arylpiperazine, a N-alkylpiperazine, a dichlorobenzene and a member of phenylureas.
target
FGFR1
References
1) Guagnano?et al.?(2011),?Discovery of 3-(2,6-Dichloro-3,5-dimethoxyphenyl)-1-(6-{[4-(4-ethyl-1-piperazinyl)phenyl]amino}-4-pyrimidinyl)-1-methylurea (NVP-BGJ398),?a Potent and Selective Inhibitor of the Fibroblast Growth Factor Receptor Family of Receptor Tyrosine Kinase?; J. Med. Chem.?54?7066 2) Komla-Ebri?et al.?(2016),?Tyrosine kinase inhibitor NVP-BGJ398 functionally improves FGFR3-related dwarfism in mouse model; J. Clin. Invest.?126?1871
Infigratinib Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| PharmOrgSyn Laboratories Co., Ltd. | +86-021-38228826 +86-13916602830 | sales@pharmorgsyn.cn | China | 140 | 58 |
| shandong perfect biotechnology co.ltd | +86-53169958659; +8618596095638 | sales@sdperfect.com | China | 294 | 58 |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9352 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 967 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
Related articles
- Infigratinib: Synthesis and Introduction
- Infigratinib was synthesized in a modular and convergent fashion via the union of three building blocks.
- Jan 29，2024
View Lastest Price from Infigratinib manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-03-12 | Infigratinib (BGJ398)
872511-34-7
|
US $0.00 / g | 1g | 98% HPLC | 1kg | shandong perfect biotechnology co.ltd | |
![3-(2,6-Dichloro-3,5-dimethoxyphenyl)-1-[6-[[4-(4-ethylpiperazin-1-yl)phenyl]amino]pyrimidin-4-yl]-1-methylurea pictures](https://img.chemicalbook.com/ProductImageEN/2020-1/Small/19ad71e7-73a0-43a9-a5bc-6db9903bff82.jpg) |
2020-01-09 | 3-(2,6-Dichloro-3,5-dimethoxyphenyl)-1-[6-[[4-(4-ethylpiperazin-1-yl)phenyl]amino]pyrimidin-4-yl]-1-methylurea
872511-34-7
|
US $2.00 / KG | 1g | 98%min | ask | Career Henan Chemical Co |
-
- Infigratinib (BGJ398)
872511-34-7
- US $0.00 / g
- 98% HPLC
- shandong perfect biotechnology co.ltd
-
- 3-(2,6-Dichloro-3,5-dimethoxyphenyl)-1-[6-[[4-(4-ethylpiperazin-1-yl)phenyl]amino]pyrimidin-4-yl]-1-methylurea
872511-34-7
- US $2.00 / KG
- 98%min
- Career Henan Chemical Co
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