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5-Methyl-3,4-diphenylisoxazole

5-Methyl-3,4-diphenylisoxazole structure

CAS No.: 37928-17-9

Chemical Name:: 5-Methyl-3,4-diphenylisoxazole

Synonyms: 5-Methyl-3;CAS:37928-17-9;Parecoxib Sodium-4;5-Methyl-3,4-diphenyl;Parecoxib Related Compound;5-Methyl-3,4-diphenylisoxazole;3,4-Diphenyl-5-methylisoxazole;Parecoxib SodiuM iMpurity PR-SM;Parecoxib SodiuM interMediate A;Isoxazole, 5-Methyl-3,4-diphenyl-

CBNumber:: CB52604537

Molecular Formula:: C16H13NO

Molecular Weight:: 235.28

MDL Number:: MFCD18449672

MOL File:: 37928-17-9.mol

Last updated:2023-10-09 22:51:44

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5-Methyl-3,4-diphenylisoxazole Properties

Melting point	96.0 to 100.0 °C
Boiling point	340.1±21.0 °C(Predicted)
Density	1.108±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
solubility	Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
form	Solid
pka	-2.53±0.50(Predicted)
color	White to Off-White
InChIKey	ZXIRUKJWLADSJS-UHFFFAOYSA-N

SAFETY

Risk and Safety Statements

HS Code

2934.99.4400

NFPA 704

	1
2		0

5-Methyl-3,4-diphenylisoxazole price More Price(16)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	M2830	5-Methyl-3,4-diphenylisoxazole >98.0%(GC)	37928-17-9	1g	$36	2024-03-01	Buy
TCI Chemical	M2830	5-Methyl-3,4-diphenylisoxazole >98.0%(GC)	37928-17-9	5g	$91	2024-03-01	Buy
TRC	M312540	5-Methyl-3,4-diphenylisoxazole	37928-17-9	500mg	$75	2021-12-16	Buy
American Custom Chemicals Corporation	CHM0390904	5-METHYL-3,4-DIPHENYLISOXAZOLE 95.00%	37928-17-9	5MG	$497.88	2021-12-16	Buy
AK Scientific	Y0376	5-Methyl-3,4-diphenylisoxazole	37928-17-9	25g	$178	2021-12-16	Buy

Product number	Packaging	Price	Buy
M2830	1g	$36	Buy
M2830	5g	$91	Buy
M312540	500mg	$75	Buy
CHM0390904	5MG	$497.88	Buy
Y0376	25g	$178	Buy

5-Methyl-3,4-diphenylisoxazole Chemical Properties,Uses,Production

Uses

5-Methyl-3,4-diphenylisoxazole is a reagent for the preparation of valdecoxib and valdecoxib analogues.

Uses

5-Methyl-3,4-diphenylisoxazole is synthesis The key intermediate of Parecoxib Sodium (Parecoxib Sodium).Parecoxib Sodium is by the Pfizer of the U.S. The cox 2 inhibitor of company's research and development, listed in European Union in 2002, trade name Dynastat, is used for The short term therapy of postoperative pain.

Synthesis

Synthesis_37928-17-9
In four mouthfuls of round-bottomed flasks of a 1L add compound 2 (40g), methanol (400mL), 7.7% Aqueous sodium carbonate (400mL), is heated to 70 DEG C, after stirring reaction 2h, and TLC plate monitoring raw material Fundamental reaction is complete, and solution is divided into solid-liquid biphase, is extracted with ethyl acetate, collected organic layer, with anhydrous Sodium sulfate is dried, and vacuum obtains white solid, HPLC purity: 94.9% after being spin-dried for.White solid uses 40ml ethyl acetate and the mixed solvent recrystallization of 120ml normal hexane (1:3) again, Obtaining target compound is white solid 34.2g, yield 92%, HPLC purity: 99.7%.m.p.97-98??￡? MS(m/z):236(M+H)+￡?1H NMR(400MHz,CDCl3) |?:2.43(s,3H,-CH3), 7.19-7.43 (m, 10H ,-CH=).

5-Methyl-3,4-diphenylisoxazole Preparation Products And Raw materials

Raw materials

Preparation Products

Parecoxib Valdecoxib Valdecoxib IMpurity B

5-Methyl-3,4-diphenylisoxazole Suppliers

Global( 300)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Yingrui Biopharma Co.,Ltd	21-33585366	export01@shyrchem.com	CHINA	1320	58
ZHEJIANG ESTCHEM CO.,LTD	15957180504	sales@zjestchem.com	China	193	58
Hebei Mojin Biotechnology Co., Ltd	+8613288715578	sales@hbmojin.com	China	12456	58
Hebei Yanxi Chemical Co., Ltd.	+8617531190177	peter@yan-xi.com	China	5993	58
Henan Bao Enluo International TradeCo.，LTD	+86-17331933971 +86-17331933971	deasea125996@gmail.com	China	2503	58
Hangzhou ICH Biofarm Co., Ltd	+undefined8613073685410	sales@ichemie.com	China	985	58
Anhui Ruihan Technology Co., Ltd	+8617756083858	daisy@anhuiruihan.com	China	994	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	15928	58
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	fandachem@gmail.com	China	9348	55

Supplier	Advantage
Shanghai Yingrui Biopharma Co.,Ltd	58
ZHEJIANG ESTCHEM CO.,LTD	58
Hebei Mojin Biotechnology Co., Ltd	58
Hebei Yanxi Chemical Co., Ltd.	58
Henan Bao Enluo International TradeCo.，LTD	58
Hangzhou ICH Biofarm Co., Ltd	58
Anhui Ruihan Technology Co., Ltd	58
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
Hangzhou FandaChem Co.,Ltd.	55

View Lastest Price from 5-Methyl-3,4-diphenylisoxazole manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-04-24	5-Methyl-3,4-diphenylisoxazole 37928-17-9	US $100.00-60.00 / Grams	100Grams	99.99%	100Tons	Hebei Dangtong Import and export Co LTD
2023-11-01	5-Methyl-3,4-diphenylisoxazole 37928-17-9	US $0.00-0.00 / kg	1kg	99%	500KG	Hangzhou ICH Biofarm Co., Ltd
2023-10-09	5-Methyl-3,4-diphenylisoxazole 37928-17-9	US $0.00 / kg	1kg	0.99	20tons	Hebei Yanxi Chemical Co., Ltd.

5-Methyl-3,4-diphenylisoxazole
37928-17-9
US $100.00-60.00 / Grams
99.99%
Hebei Dangtong Import and export Co LTD

5-Methyl-3,4-diphenylisoxazole
37928-17-9
US $0.00-0.00 / kg
99%
Hangzhou ICH Biofarm Co., Ltd

5-Methyl-3,4-diphenylisoxazole
37928-17-9
US $0.00 / kg
0.99
Hebei Yanxi Chemical Co., Ltd.

37928-17-9(5-Methyl-3,4-diphenylisoxazole)Related Search:

BenzenesulfonaMide, 3-[4-[4-(aMinosulfonyl)phenyl]-5-Methyl-3-isoxazolyl]- Valdecoxib IMpurity B Parecoxib 1-Hydroxy Valdecoxib Parecoxib Impurity 18

Valdecoxib 3'-Sulfonyl Chloride IMpurity 5-Methyl-3-phenyl-4-(phenylMethyl)isoxazole 4-(4-chlorophenyl)-5-methyl-3-phenylisoxazole N-((4-(5-Methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)acetaMide 4-[(5-Methyl-3-phenyl-4-isoxazolyl)methyl]benzenesulfonamide

2-Phenylacetophenone 3-methyl -4,5-diphenyl-4,5-didydro-isoxazole Valdecoxib IMpurity-E Valdecoxib Deoxybenzoin Oxime

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1of4

Isoxazole, 5-Methyl-3,4-diphenyl- (Parecoxib sodiuM inteMediate) Isoxazole, 5-Methyl-3,4-diphenyl- 3,4-Diphenyl-5-methylisoxazole 5-Methyl-3,4-diphenylisoxazole 3-Phenyl-4-(4-aMinosulfonylbenzyl)-5-Methylisoxazole,Valdecoxib IMpurity A Parecoxib SodiuM interMediate A Parecoxib InterMediate (5-Mehyl-3,4-Diphenylisoxazole) 5-Methyl-3,4-diphenyl- (Parecoxib sodiuM inteMediate) CAS:37928-17-9 Parecoxib SodiuM iMpurity PR-SM Isoxazole, 5-Methyl-3,4-diphenyl- (Parecoxib sodiuM intermediate) Parecoxib intermediates，5-Methyl-3,4-diphenylisoxazole Isoxazole, 5-Methyl-3,4-diphenyl- (Parecoxib sodiuM inteMediate) ISO 9001：2015 REACH PARECOXIB SODIUM CAS 198470-85-8 INTERMEDIATES 5-Methyl-3,4-diphenyl-1,2-oxazole Parecoxib Sodium-4 Valdecoxib Impurity 10 (Desulfonamide) (Parecoxib Impurity 19) Parecoxib Impurity 19 (Valdecoxib Impurity 10 (Desulfonamide)) Parecoxib Related Compound Parecoxib impurity 5/5-methyl-3,4-diphenylisoxazole 5-Methyl-3 4-diphenyl-(Parecoxib sodiuM inteMediate) Valdecoxib Impurity 10 (Desulfonamide) lsoxazole,5-Methyl-3,4-diphenyl-(Parecoxib sodiuM inteMediate) 5-Methyl-3,4-diphenyl Parecoxib Impurity 19 (Desulfonamide) 37928-17-9 37928-19-7 API