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3',4',5'-trifluorobiphenyl-2-aMine

3',4',5'-trifluorobiphenyl-2-aMine structure

CAS No.: 915416-45-4

Chemical Name:: 3',4',5'-trifluorobiphenyl-2-aMine

Synonyms: Fluxapyroxad-002;3,4,5-Trifluoro-2'-aminobiphenyl;2-(3,4,5-Trifluorophenyl)aniline;3',4',5'-trifluoro-2-aminobiphenyl;3',4',5'-trifluorobiphenyl-2-aMine;3',4',5'-Trifluorobiphenyl-2-ylamine;3',4',5'-trifluoro-[1,1'-biphenyl]-2-am;3',4',5'-trifluoro-[1,1'-biphenyl]-2-am;3',4',5'-trifluoro-[1,1'-biphenyl]-2-aMine;[1,1'-Biphenyl]-2-amine, 3',4',5'-trifluoro-

CBNumber:: CB52609769

Molecular Formula:: C12H8F3N

Molecular Weight:: 223.19

MDL Number:: MFCD14603436

MOL File:: 915416-45-4.mol

Last updated:2025-09-05 20:24:49

Product description	Number	Pack Size	Price
3'',4'',5''-Trifluoro-[1,1''-biphenyl]-2-amine	T304270	500mg	$180
3',4',5'-TRIFLUORO-[1,1'-BIPHENYL]-2-AMINE 95.00%	HCH0364083	100MG	$274.05
3',4',5'-Trifluoro-[1,1'-biphenyl]-2-amine	W9483	10g	$1330
3',4',5'-Trifluoro-[1,1'-biphenyl]-2-amine	W9483	25g	$2353
3',4,5-Trifluorobiphenyl-2-amine	1214360572	1g	$1445.3
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3',4',5'-trifluorobiphenyl-2-aMine Properties

Boiling point	303.7±37.0 °C(Predicted)
Density	1.315
storage temp.	2-8°C(protect from light)
solubility	DMSO (Slightly), Methanol (Slightly)
pka	2.17±0.10(Predicted)
form	Solid
color	Off-White to Light Beige
InChI	InChI=1S/C12H8F3N/c13-9-5-7(6-10(14)12(9)15)8-3-1-2-4-11(8)16/h1-6H,16H2
InChIKey	FTIKVBVUYPQUBF-UHFFFAOYSA-N
SMILES	C1(C2=CC(F)=C(F)C(F)=C2)=CC=CC=C1N
FDA UNII	10XDA3W53S
EPA Substance Registry System	[1,1'-Biphenyl]-2-amine, 3',4',5'-trifluoro- (915416-45-4)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS09
Signal word	Danger
Hazard statements	H410
Precautionary statements	P273-P391-P501

3',4',5'-trifluorobiphenyl-2-aMine price More Price(16)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	T304270	3'',4'',5''-Trifluoro-[1,1''-biphenyl]-2-amine	915416-45-4	500mg	$180	2021-12-16	Buy
American Custom Chemicals Corporation	HCH0364083	3',4',5'-TRIFLUORO-[1,1'-BIPHENYL]-2-AMINE 95.00%	915416-45-4	100MG	$274.05	2021-12-16	Buy
AK Scientific	W9483	3',4',5'-Trifluoro-[1,1'-biphenyl]-2-amine	915416-45-4	10g	$1330	2021-12-16	Buy
AK Scientific	W9483	3',4',5'-Trifluoro-[1,1'-biphenyl]-2-amine	915416-45-4	25g	$2353	2021-12-16	Buy
Alichem	1214360572	3',4,5-Trifluorobiphenyl-2-amine	915416-45-4	1g	$1445.3	2021-12-16	Buy

Product number	Packaging	Price	Buy
T304270	500mg	$180	Buy
HCH0364083	100MG	$274.05	Buy
W9483	10g	$1330	Buy
W9483	25g	$2353	Buy
1214360572	1g	$1445.3	Buy

3',4',5'-trifluorobiphenyl-2-aMine Chemical Properties,Uses,Production

Uses

3'',4'',5''-Trifluoro-[1,1''-biphenyl]-2-amine is a building block used in various chemical synthesis.

Flammability and Explosibility

Non flammable

Synthesis

Benzenamine, 2-chloro-N-(phenylmethylene)-

884-29-7

156006-28-9

915416-45-4

In a 1 liter reactor, zinc chloride (20 g, 0.147 mol) was mixed with THF (29 g) and heated to a suitable temperature. Subsequently, a THF solution (1.15 mmol/g solution) of 3,4,5-trifluorophenylmagnesium bromide (0.133 mol) was added. After stirring for 10 min, (1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)(3-chloropyridyl)-palladium(II) dichloride (462 mg) was added at 25 °C. After 5 min, N-methylpyrrolidone (30 g) was added. after 10 min, phenylmethylideneamino-2-chlorobenzene, 99% pure, was added to the reaction mixture (29 g, 0.133 moles). Subsequently, the mixture was heated to 50 °C and stirred at this temperature for 6 hours. The post-treatment step consisted of adding 3.4 g of activated carbon, stirring the suspension for 1 hour and then filtering through diatomaceous earth. The filter cake was washed with THF (200 g) and the filtrate was subsequently concentrated. Concentration was carried out using a rotary evaporator at 50 °C and a vacuum below 5 mbar. Water (200 g) and concentrated sulfuric acid (28 g) were added to the residue. The mixture was stirred at 80 °C for 3 h while the generated benzaldehyde was removed by azeotropic distillation. Afterwards, the pH was adjusted to 2.8 with sodium hydroxide solution and toluene (200 g) was added. After separation of the organic phase, the aqueous phase was re-extracted with toluene (200 g) and the combined organic phases were washed with water (100 g) and concentrated. Concentration at 80 °C and 5 mbar using a rotary evaporator yielded a dark colored oil (26.7 g), which crystallized after standing. Quantitative HPLC analysis showed 86.4% by weight of 3,4,5-trifluoro-2'-aminobiphenyl in the oily substance, corresponding to 78% yield.

References

[1] Patent: US2011/301356, 2011, A1. Location in patent: Page/Page column 10

3',4',5'-trifluorobiphenyl-2-aMine synthesis

Synthesis of 3',4',5'-trifluorobiphenyl-2-aMine from 2-Chloroaniline and 3,4,5-Trifluorophenylboronic acid

3',4',5'-trifluorobiphenyl-2-aMine Preparation Products And Raw materials

Raw materials

4-(3,4,5-TRIFLUOROPHENYL)ANILINE Benzenamine, 2-chloro-N-(phenylmethylene)- 3 4 5-TRIFLUOROPHENYLMAGNESIUM BROMIDE 3',4',5'-trifluoro-2-nitrobiphenyl 5-Bromo-1,2,3-trifluorobenzene

3,4,5-Trifluorophenylboronic acid Tetrahydrofuran Aniline 2-Chloroaniline 2-Bromoaniline

1of2

Preparation Products

3',4',5'-trifluorobiphenyl-2-aMine Suppliers

Global( 136)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Labnetwork lnc.	+86-27-50766799 +8618062016861	contact@labnetwork.com	China	19987	58
Zhengzhou Anhuida Chemical Co., Ltd	+8615903659408	admin@ahdchem.com	China	286	58
PNP Biotech Co. Ltd	+8618516098983	sales@pnpbiotech.com	China	1001	58
Shanghai Cube Chemical Co., Ltd.	+86-02156500520 +86-18116101847	kevin.li@cubechem.com	China	43	58
Shaanxi Dideu Medichem Co. Ltd	+86-29-81139210 +86-18192627656	1059@dideu.com	China	3588	58
Firsky International Trade (Wuhan) Co., Ltd	+8615387054039	admin@firsky-cn.com	China	427	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21612	55
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28172	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29798	58
Zhengzhou Alfa Chemical Co.,Ltd	+8618530059196	sale04@alfachem.cn	China	11767	58

Supplier	Advantage
Labnetwork lnc.	58
Zhengzhou Anhuida Chemical Co., Ltd	58
PNP Biotech Co. Ltd	58
Shanghai Cube Chemical Co., Ltd.	58
Shaanxi Dideu Medichem Co. Ltd	58
Firsky International Trade (Wuhan) Co., Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55
Hubei Jusheng Technology Co.,Ltd.	58
career henan chemical co	58
Zhengzhou Alfa Chemical Co.,Ltd	58

View Lastest Price from 3',4',5'-trifluorobiphenyl-2-aMine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-12-12	3',4',5'-trifluorobiphenyl-2-aMine 915416-45-4	US $1.00-4.00 / KG	1KG	99%	200000KG	Shaanxi Dideu Medichem Co. Ltd
2025-12-01	3',4',5'-trifluorobiphenyl-2-amine 915416-45-4	US $0.00 / kg	1kg	98%	1000kg	Shaanxi Dideu New Materials Co. Ltd
2024-03-28	3',4',5'-Trifluoro-[1,1'-biphenyl]-2-amine 915416-45-4	US $0.00 / kg	25kg	98%	Inquiry	PNP Biotech Co. Ltd

3',4',5'-trifluorobiphenyl-2-aMine
915416-45-4
US $1.00-4.00 / KG
99%
Shaanxi Dideu Medichem Co. Ltd

3',4',5'-trifluorobiphenyl-2-amine
915416-45-4
US $0.00 / kg
98%
Shaanxi Dideu New Materials Co. Ltd

3',4',5'-Trifluoro-[1,1'-biphenyl]-2-amine
915416-45-4
US $0.00 / kg
98%
PNP Biotech Co. Ltd

915416-45-4(3',4',5'-trifluorobiphenyl-2-aMine)Related Search:

3,3'-Dihydroxybenzidine

3',4',5'-trifluorobiphenyl-2-aMine 3',4',5'-trifluoro-[1,1'-biphenyl]-2-aMine 2-(3,4,5-Trifluorophenyl)aniline 3,4,5-Trifluoro-2'-aminobiphenyl 3',4',5'-Trifluorobiphenyl-2-ylamine [1,1'-Biphenyl]-2-amine, 3',4',5'-trifluoro- Fluxapyroxad-002 3',4',5'-trifluoro-2-aminobiphenyl 3',4',5'-trifluoro-[1,1'-biphenyl]-2-am 3',4',5'-trifluoro-[1,1'-biphenyl]-2-am 915416-45-4 1