Vipadenant
- CAS No.
- 442908-10-3
- Chemical Name:
- Vipadenant
- Synonyms
- V 2006;CS-2294;BIIB 014;CEB 4520;VER 11135;Vipadenant;VER-ADO 49;VER-A 00-11;VER-A 00049;BIIB-014, CEB-4520
- CBNumber:
- CB52627600
- Molecular Formula:
- C16H15N7O
- Molecular Weight:
- 321.34
- MDL Number:
- MFCD12024697
- MOL File:
- 442908-10-3.mol
- MSDS File:
- SDS
| Melting point | 245.3-246.1 °C |
|---|---|
| Boiling point | 668.5±65.0 °C(Predicted) |
| Density | 1.56±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO:37.0(Max Conc. mg/mL);115.14(Max Conc. mM) |
| form | A crystalline solid |
| pka | 4.27±0.30(Predicted) |
| FDA UNII | LDR3USH1NJ |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H400-H410 | |||||||||
| Precautionary statements | P264-P270-P273-P301+P312-P330-P391-P501 | |||||||||
| NFPA 704 |
|
Vipadenant price More Price(17)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 20239 | Vipadenant ≥98% | 442908-10-3 | 500μg | $68 | 2024-03-01 | Buy |
| Cayman Chemical | 20239 | Vipadenant ≥98% | 442908-10-3 | 1mg | $121 | 2024-03-01 | Buy |
| Cayman Chemical | 20239 | Vipadenant ≥98% | 442908-10-3 | 5mg | $469 | 2024-03-01 | Buy |
| TRC | V670808 | Vipadenant | 442908-10-3 | 50mg | $1440 | 2021-12-16 | Buy |
| TRC | V670808 | Vipadenant | 442908-10-3 | 5mg | $255 | 2021-12-16 | Buy |
Vipadenant Chemical Properties,Uses,Production
Description
Vipadenant (also known as BIIB014) is a potent, selective oral adenosine A2A receptor antagonist under development for the treatment of Parkinson’s disease. It has successfully completed phase I clinical studies. It might also be a potential adjunctive therapy reagent for cancer treatment. It was found that it has certain potentials to disrupt an immunosuppressive mechanism of tumour protection, generating improved efficacy for immunotherapies of certain cancers when used in combination with other drugs.
References
http://www.medkoo.com/products/8047
Shook, B. C., and P. F. Jackson. "Adenosine A(2A) Receptor Antagonists and Parkinson's Disease. " Acs Chemical Neuroscience2.10(2011):555-67.
Brooks, D. J., et al. "An open-label, positron emission tomography study to assess adenosine A2A brain receptor occupancy of vipadenant (BIIB014) at steady-state levels in healthy male volunteers." Clinical Neuropharmacology 33.2(2010):55.
http://www.vernalis.com/nce-pipeline/oncology/v2006
Uses
Vipadenant is a potent, selective and orally available adenosine A2A receptor antagonist under development for for Parkinson''s disease. Vipadenant demonstrates strong oral activity in commonly used models of Parkinson''s disease. Vipadenant has shown excellent preclinical pharmacokinetics and has successfully completed phase I clinical studies.
Vipadenant Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24738 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
View Lastest Price from Vipadenant manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-02 | Vipadenant
442908-10-3
|
US $1.00 / KG | 1KG | Min98% HPLC | g/kg/ton | Career Henan Chemical Co |
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- Vipadenant
442908-10-3
- US $1.00 / KG
- Min98% HPLC
- Career Henan Chemical Co