GSK 189254A
- CAS No.
- 720690-73-3
- Chemical Name:
- GSK 189254A
- Synonyms
- CS-2905;GSK 189254A;histamine H3 receptor antagonist GS189254A;Histamine Receptor,GSK-189254,GSK 189254,GSK-189254A,inhibit,GSK189254A,Inhibitor;6-(3-cyclobutyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yloxy)-N-MethylnicotinaMide;N-(4-METHOXYBENZYL)-1-[(4-METHYLPHENYL)SULFONYL]-1H-PYRROLO[2,3-B
]PYRIDIN-4-AMINE;6-[(3-cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)oxy]-N-methylpyridine-3-carboxamide;3-Pyridinecarboxamide, 6-[(3-cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)oxy]-N-methyl-
- CBNumber:
- CB52627923
- Molecular Formula:
- C21H25N3O2
- Molecular Weight:
- 351.44
- MDL Number:
- MOL File:
- 720690-73-3.mol
- MSDS File:
- SDS
| Boiling point | 545.0±50.0 °C(Predicted) |
|---|---|
| Density | 1.195±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO:25.0(Max Conc. mg/mL);71.13(Max Conc. mM) |
| form | A solid |
| pka | 14.26±0.46(Predicted) |
| FDA UNII | 5T4TX6CO53 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P321-P362+P364-P332+P313-P337+P313-P403+P233-P405-P501 | |||||||||
| NFPA 704 |
|
GSK 189254A price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-6206 | GSK189254A 98.45% | 720690-73-3 | 1mg | $60 | 2021-12-16 | Buy |
| ChemScene | CS-6206 | GSK189254A 98.45% | 720690-73-3 | 5mg | $100 | 2021-12-16 | Buy |
| ChemScene | CS-6206 | GSK189254A 98.45% | 720690-73-3 | 10mg | $150 | 2021-12-16 | Buy |
| ChemScene | CS-6206 | GSK189254A 98.45% | 720690-73-3 | 50mg | $450 | 2021-12-16 | Buy |
| ChemScene | CS-6206 | GSK189254A 98.45% | 720690-73-3 | 100mg | $650 | 2021-12-16 | Buy |
GSK 189254A Chemical Properties,Uses,Production
Description
GSK189254A is a histamine H3 receptor antagonist for the treatment of narcolepsy.It may also be useful for the treatment of dementia and neuropathic pain. Its pharmacological effect may be related to its effect on increasing the release neurotransmitter in the brain. Microdialysis studies demonstrated that GSK189254 increased the release of acetylcholine, noradrenaline, and dopamine in the anterior cingulate cortex and acetylcholine in the dorsal hippocampus. GSK189254 significantly improved performance of rats in diverse cognition paradigms, including passive avoidance, water maze, object recognition, and attentional set shift. These data suggest that GSK189254 may have therapeutic potential for the symptomatic treatment of dementia in Alzheimer's disease and other cognitive disorders.
References
Medhurst, Andrew D., and A. I. J. Beresford. "GSK189254, a novel H3 receptor antagonist that binds to histamine H3 receptors in Alzheimer's disease brain and improves cognitive performance in preclinical models." Alzheimers & Dementia 321.3(2007):1032.
Plisson, Christophe, et al. "PET imaging of the CNS histamine H3 receptor using [11C] GSK189254A." Neuroimage 31.1(2006):T47-T47.
http://medkoo.com/products/10117
GSK 189254A Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24738 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Chengdu Henghui Pharm Tec Co. Ltd. | 13540674322 15828370308 | CHINA | 121 | 55 | |
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2923 | 55 | |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4863 | 58 |
| Shanghai XR Chemical Technology Co., Ltd. | 021-31007982 18019432809 | info@xrpharma.com | China | 766 | 55 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4121 | 55 |