3-(azepan-1-ylsulfonyl)-N-(3-broMophenyl)benzaMide
- CAS No.
- 420831-40-9
- Chemical Name:
- 3-(azepan-1-ylsulfonyl)-N-(3-broMophenyl)benzaMide
- Synonyms
- AK-7;CS-922;AK 7, >=98%;AK-7;AK7;AK 7;SIRT2 Inhibitor II;SIRT2 Inhibitor,AK-7;SIRT2 Inhibitor II, AK-7;SIRT2 INHIBITOR II;AK7;AK 7;3-(azepan-1-ylsulfonyl)-N-(3-broMophenyl)benzaMide;N-(3-Bromophenyl)-3-[(hexahydro-1H-azepin-1-yl)sulfonyl]-benzamide
- CBNumber:
- CB52639218
- Molecular Formula:
- C19H21BrN2O3S
- Molecular Weight:
- 437.35
- MDL Number:
- MFCD03140195
- MOL File:
- 420831-40-9.mol
- MSDS File:
- SDS
| Density | 1.469±0.06 g/cm3(Predicted) |
|---|---|
| storage temp. | Sealed in dry,2-8°C |
| solubility | DMSO: ≥15mg/mL |
| form | powder |
| pka | 12.28±0.70(Predicted) |
| color | white to tan |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. |
| FDA UNII | 308B6B695N |
3-(azepan-1-ylsulfonyl)-N-(3-broMophenyl)benzaMide price More Price(31)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0152 | AK-7 ≥98% (HPLC) | 420831-40-9 | 5mg | $116 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML0152 | AK-7 ≥98% (HPLC) | 420831-40-9 | 25mg | $451 | 2024-03-01 | Buy |
| Cayman Chemical | 14004 | AK-7 ≥95% | 420831-40-9 | 5mg | $73 | 2024-03-01 | Buy |
| Cayman Chemical | 14004 | AK-7 ≥95% | 420831-40-9 | 10mg | $138 | 2024-03-01 | Buy |
| Cayman Chemical | 14004 | AK-7 ≥95% | 420831-40-9 | 25mg | $324 | 2024-03-01 | Buy |
3-(azepan-1-ylsulfonyl)-N-(3-broMophenyl)benzaMide Chemical Properties,Uses,Production
Description
The sirtuin SIRT2 is a deacetylase which targets α-
Uses
AK-7 is a deacetylase which targets α-tubulin, histone 4, forkhead transcription factors, and several other substrates it is also a selective SIRT2 inhibitor.
storage
+4°C
References
1) Tylor et al. (2011), A brain-permeable small molecule that reduces neuronal cholesterol by inhibiting activity of sirtuin 2 deacetylase; ACS Chem. Biol., 6 540 2) Chopra et al. (2012), The sirtuin 2 inhibitor AK-7 is neuroprotective in Huntington’s disease mouse models; Cell Rep., 2 1492
3-(azepan-1-ylsulfonyl)-N-(3-broMophenyl)benzaMide Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| TopScience Biochemical | 00852-68527855 | info@itopbiochem.com | China Hong Kong | 902 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Coresyn Pharmatech Co., Ltd. | +86-571-86626709 +86-18157142896 | cbc@coresyn.com | China | 9991 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |