RVX-208
- CAS No.
- 1044870-39-4
- Chemical Name:
- RVX-208
- Synonyms
- CS-686;CS-1815;RVX-208;RVX-000222;Apabetalone;RVX-208 USP/EP/BP;RVX-208(RVX000222);RVX-208(RVX 000222);Apabetalone-RVX-208;Apabetalone (RVX-08, RVX-000222)
- CBNumber:
- CB52640278
- Molecular Formula:
- C20H22N2O5
- Molecular Weight:
- 370.4
- MDL Number:
- MFCD18633270
- MOL File:
- 1044870-39-4.mol
- MSDS File:
- SDS
| Boiling point | 594.2±60.0 °C(Predicted) |
|---|---|
| Density | 1.28±0.1 g/cm3(Predicted) |
| storage temp. | -20°C (des.) |
| solubility | Soluble in DMSO (up to 75 mg/ml) or in Ethanol (up to 4 mg/ml). |
| form | solid |
| pka | 14.21±0.10(Predicted) |
| color | White |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month. |
| FDA UNII | 8R4A7GDZ1D |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|---|---|
| Signal word | Warning |
| Hazard statements | H371 |
| Precautionary statements | P260-P264-P270-P309+P311-P405-P501 |
RVX-208 price More Price(28)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 16424 | RVX-208 ≥98% | 1044870-39-4 | 1mg | $44 | 2024-03-01 | Buy |
| Cayman Chemical | 16424 | RVX-208 ≥98% | 1044870-39-4 | 5mg | $109 | 2024-03-01 | Buy |
| Cayman Chemical | 16424 | RVX-208 ≥98% | 1044870-39-4 | 10mg | $193 | 2024-03-01 | Buy |
| Cayman Chemical | 16424 | RVX-208 ≥98% | 1044870-39-4 | 25mg | $404 | 2024-03-01 | Buy |
| TRC | R800000 | RVX208 | 1044870-39-4 | 25mg | $330 | 2021-12-16 | Buy |
RVX-208 Chemical Properties,Uses,Production
Description
The bromodomain and extra terminal (BET) proteins interact with acetylated lysine-containing sequences on target proteins via their bromodomains, commonly altering gene transcription. The human BET proteins contain two bromodomains, the first (BD1) being closer to the N-terminus than the second (BD2). RVX-208 is a selective antagonist of BET bromodomains, binding with 10-100-fold higher affinity for BD2 (IC50 = 0.04-0.28 μM) over BD1 (IC50 = 1.8-3.1 μM). RVX-208 causes the selective release of BET proteins from chromatin in cells. It interferes with the BET protein BRD4, resulting in an increased expression of apolipoprotein (Apo) A1 in cells, mice, monkeys, and humans. RVX-208 also reduces atherosclerosis in hyperlipidemic ApoE-deficient mice.
Uses
RVX-208 is a selective antagonist of bromodomain and extra terminal (BET)’s bromodomains.
target
BD2
References
1) Picaud?et al. (2013),?RVX-208, an inhibitor of BET transcriptional regulators with selectivity for the second bromodomain; Proc. Natl. Acad. Sci. USA,?110?19754 2) McLure?et al. (2013),?RVX-208, an inducer of ApoA-I in humans, is a BET bromodomain antagonist; PLoS One,?8e83190 3) Bailey?et al. (2010),?RVX-208: a small molecule that increases apolipoprotein A-I and high-density lipoprotein cholesterol in vitro and in vivo; J. Am. Coll. Cardiol.,?55?2580 4) Jahagirdar?et al. (2014),?A novel BET bromodomain inhibitor, RVX-208 shows reduction of atherosclerosis in hyperlipidemic ApoE deficient mice; Atherosclerosis,?236?91
RVX-208 Preparation Products And Raw materials
Raw materials
1of3
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 967 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Changzhou Xuanming Pharmaceutical Technology Co., Ltd. | +8618068519287 | sales@xuanmingchem.com | China | 822 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29220 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Nanjing Doge Biomedical Technology Co., Ltd | +86-25-58227606 +86-15305155328 | sales@dogechemical.com | China | 4128 | 58 |
