J 147
- CAS No.
- 1146963-51-0
- Chemical Name:
- J 147
- Synonyms
- J 147;CS-1446;J147-API;J147/J-147;J-147?, >98%;Nootropic J147;J 147(Nootropic Powder);CAS 1146963-51-0 J 147;N-(2,4-DIMETHYLPHENYL)-N'-(3-METHOXYBENZYLIDENE)ACETOHYDRAZIDE;N-(2,4-Dimethylphenyl)-2,2,2-trifluoro-N'-(3-methoxybenzylidene)acetohydrazide
- CBNumber:
- CB52652639
- Molecular Formula:
- C18H17F3N2O2
- Molecular Weight:
- 350.33
- MDL Number:
- MFCD25976644
- MOL File:
- 1146963-51-0.mol
| Boiling point | 412.8±55.0 °C(Predicted) |
|---|---|
| Density | 1.18±0.1 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO:68.0(Max Conc. mg/mL);194.1(Max Conc. mM) |
| form | Powder |
| pka | 0.80±0.50(Predicted) |
| InChI | InChI=1S/C18H17F3N2O2/c1-12-7-8-16(13(2)9-12)23(17(24)18(19,20)21)22-11-14-5-4-6-15(10-14)25-3/h4-11H,1-3H3 |
| InChIKey | HYMZAYGFKNNHDN-UHFFFAOYSA-N |
| SMILES | C(N(C1=CC=C(C)C=C1C)N=CC1=CC=CC(OC)=C1)(=O)C(F)(F)F |
| FDA UNII | Z41H3C5BT9 |
J 147 price More Price(25)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Tocris | 5081 | J147 ≥99%(HPLC) | 1146963-51-0 | 10 | $182 | 2021-12-16 | Buy |
| Tocris | 5081 | J147 ≥99%(HPLC) | 1146963-51-0 | 50 | $745 | 2021-12-16 | Buy |
| TRC | J210300 | J147 | 1146963-51-0 | 10mg | $165 | 2021-12-16 | Buy |
| ApexBio Technology | B5804 | J147 | 1146963-51-0 | 10mg | $171 | 2021-12-16 | Buy |
| ChemScene | CS-3688 | J-147 99.87% | 1146963-51-0 | 5mg | $90 | 2021-12-16 | Buy |
J 147 Chemical Properties,Uses,Production
Uses
J 147 is a novel neurotrophic drug for cognitive enhancement and Alzheimer''s disease. J 147 is an exceptionally potent, orally active and broadly neuroprotective compound has the ability to enhance memory in normal animals as well as to prevent memory deficits in Alzheimer''s disease (AD) transgenic mice. The neurotrophic and memory-enhancing activities of J147 are associated with an increase in brain derived neurotrophic factor (BDNF) levels and the expression of BDNF responsive proteins, the enhancement of LTP, the preservation of synaptic protein, the reduction of amyloid plaques.
Definition
ChEBI: J147 is an anilide.
benefits
J 147 improves heart health by lowering blood pressure, boosts metabolism, supports digestive and immune system function, improves cognitive function, has no side effects, and increases physical strength with long-term use. Once there is significant weight loss after taking it, this supplement helps people maintain their weight by reducing cravings and increasing energy levels. Since it helps suppress the hunger hormone that causes overeating, people who use J147 capsules for a long time are more likely to maintain their weight
Biological Activity
J 147 is a potent neuroprotective and neurotrophic compound. Protects against neurotoxicity in cortical neurons in vitro (EC50 = 25 - 200 nM). Reduces soluble Aβ40 and Aβ42 levels and increases BDNF levels in the hippocampus in vivo. Enhances memory in wild type rats. Prevents memory deficits and rescues cognitive deficits in young and aged transgenic Alzheimer's disease mice, respectively. Orally active.
storage
Store at +4°C
J 147 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei Langyou International Trading Co., Ltd | +8618874586545 | linda@xrdchem.cn | China | 197 | 58 |
| Hebei Bonster Technology Co.,Limited | +8613315996897 | bsterltd.wendy@gmail.com | China | 796 | 58 |
| Hebei Anlijie Biotechnology Co., Ltd | +8619031013551 | ably@aljbio.com | China | 177 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23556 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8617531190177 | peter@yan-xi.com | China | 5993 | 58 |
| Hebei Lingding Biotechnology Co., Ltd. | +86-18031140164 +86-19933155420 | erin@hbldbiotech.com | China | 878 | 58 |
| Sinoway Industrial co., ltd. | 0592-5800732; +8613806035118 | xie@china-sinoway.com | China | 992 | 58 |
| Nantong Guangyuan Chemicl Co,Ltd | +undefined17712220823 | admin@guyunchem.com | China | 616 | 58 |
| airuikechemical co., ltd. | +undefined86-15315557071 | sales02@airuikechemical.com | China | 994 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21691 | 55 |
View Lastest Price from J 147 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-22 | J 147
1146963-51-0
|
US $10.00-3.50 / G/Bag | 100G/Bag | 99% up, High Density | 100 KG | Sinoway Industrial co., ltd. | |
 |
2024-03-31 | J 147
1146963-51-0
|
US $35.00-25.00 / kg | 1kg | 99% | 2000000 | Shanghai Chinqesen Biotechnology Co., Ltd. | |
 |
2024-03-21 | j-147
1146963-51-0
|
US $0.00-0.00 / Kg | 1Kg | 99.99% | 200tons | airuikechemical co., ltd. |