ChemicalBook >> CAS DataBase List >>1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone

1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone

1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone structure

CAS No.: 1267610-26-3

Chemical Name:: 1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone

Synonyms: 1-(4-aMinophenyl)-3-Morpholino-5,6-dihydropyridin-2(1H)-one;Apixaban intA;Apixaban Impurity S;Apixaban Impurity 50;Apixaban Impurity 47;Apixaba inretMediate A;Apixaban related impurities 2;4-Pyrimidinol,2-methoxy-12-methyl-;1-(4-aminophenyl)-5,6-dihydro-3-(4-;1-(4-Aminophenyl)-5-Morpholin-4-yl-2,3-Dihydropyridin-6-One

CBNumber:: CB52660744

Molecular Formula:: C15H19N3O2

Molecular Weight:: 273.33

MDL Number:: MFCD22581648

MOL File:: 1267610-26-3.mol

MSDS File:: SDS

Last updated:2023-08-15 13:21:15

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1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone Properties

Melting point	>246°C (dec.)
Boiling point	491.5±45.0 °C(Predicted)
Density	1.277±0.06 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
solubility	Chloroform (Slightly), Methanol (Slightly)
form	Solid
pka	4.96±0.10(Predicted)
color	Off-White to Pale Beige
InChI	InChI=1S/C15H19N3O2/c16-12-3-5-13(6-4-12)18-7-1-2-14(15(18)19)17-8-10-20-11-9-17/h2-6H,1,7-11,16H2
InChIKey	YUGIGSPFTMLIMA-UHFFFAOYSA-N
SMILES	C1(=O)N(C2=CC=C(N)C=C2)CCC=C1N1CCOCC1

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338

1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone price More Price(12)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	A637898	1-(4-Aminophenyl)-5,6-dihydro-3-(4-morpholinyl)-2(1H)-pyridinone	1267610-26-3	1g	$425	2021-12-16	Buy
TRC	A637898	1-(4-Aminophenyl)-5,6-dihydro-3-(4-morpholinyl)-2(1H)-pyridinone	1267610-26-3	50g	$605	2021-12-16	Buy
AK Scientific	Z3503	1-(4-Aminophenyl)-5,6-dihydro-3-(4-morpholinyl)-2(1H)-pyridinone	1267610-26-3	25mg	$85	2021-12-16	Buy
Crysdot	CD11303316	1-(4-Aminophenyl)-3-morpholino-5,6-dihydropyridin-2(1H)-one 95+%	1267610-26-3	5g	$100	2021-12-16	Buy
Ambeed	A431106	1-(4-Aminophenyl)-3-morpholino-5,6-dihydropyridin-2(1H)-one 95%	1267610-26-3	25g	$105	2021-12-16	Buy

Product number	Packaging	Price	Buy
A637898	1g	$425	Buy
A637898	50g	$605	Buy
Z3503	25mg	$85	Buy
CD11303316	5g	$100	Buy
A431106	25g	$105	Buy

1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone Chemical Properties,Uses,Production

Uses

1-?(4-?Aminophenyl)?-?5,?6-?dihydro-?3-?(4-?morpholinyl)?-?2(1H)?-?pyridinone is an intermediate in the synthesis of Apixaban (A726700), A potent, direct, selective, and orally active inhibitor of coagulation factor Xa. It is a potential new oral coagulant that may be useful prevention of venous thromboembolism in total hip, knee replacement orthopedic surgery and stroke in treatment of patient with venous thromboembolic disorder or with atrial fibrillation.

Synthesis

1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone can be used as organic synthesis intermediates and pharmaceutical intermediates, mainly used in laboratory research and development processes and chemical production In the process.

Synthesis

Synthesis_1267610-26-3
Add 25L of water and 25L of methanol to the 500L reactor, add 2.5kg of compound (I) and 250g of Raney cobalt under stirring, raise the temperature to 40-50 ??C, slowly add 2.0kg of hydrazine hydrate (content 80%), keep warm 60-70 ??C, reaction for 3h, the reaction was completed, filtered with diatomaceous earth, concentrated solvent was removed, and MTBE was added to the filter cake.2.20 kg of a white solid were obtained with a yield of 98% and a purity of 99.8%.

1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone synthesis

Synthesis of 1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone from 3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one

1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone Preparation Products And Raw materials

Raw materials

Preparation Products

1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone Suppliers

Global( 249)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Jinan Million Pharmaceutical Co., Ltd	+86-531-68659554 +8613031714605	info@millionpharm.com	China	153	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1811	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21695	55
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	fandachem@gmail.com	China	9352	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
Speranza Chemical Co., Ltd.	+86-86-075521030354 +8618688942810	sophieliu@speranzachem.com	China	723	55
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Jinan Chenghui-Shuangda Chemical Co.,Ltd	+86-531-58897082	ericqiao@jnchsd.com	CHINA	158	58
Jinan Jianfeng Chemical Co., Ltd	0531-88110457; +8615562555968	info@pharmachemm.com	China	246	58

Supplier	Advantage
Jinan Million Pharmaceutical Co., Ltd	58
Capot Chemical Co.,Ltd.	60
Beijing Cooperate Pharmaceutical Co.,Ltd	55
Henan Tianfu Chemical Co.,Ltd.	55
Hangzhou FandaChem Co.,Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
Speranza Chemical Co., Ltd.	55
career henan chemical co	58
Jinan Chenghui-Shuangda Chemical Co.,Ltd	58
Jinan Jianfeng Chemical Co., Ltd	58

View Lastest Price from 1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-04-18	1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone 1267610-26-3	US $2.00 / kg	1kg	99%	1200KG/M	Jinan Million Pharmaceutical Co., Ltd
2024-04-17	1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone 1267610-26-3	US $25.00 / KG	1KG	98%	20 tons	Speranza Chemical Co., Ltd.
2023-07-19	1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone 1267610-26-3	US $30.00 / KG	1KG	99%	20 Tons	Wuhan wingroup Pharmaceutical Co., Ltd

1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone
1267610-26-3
US $2.00 / kg
99%
Jinan Million Pharmaceutical Co., Ltd

1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone
1267610-26-3
US $25.00 / KG
98%
Speranza Chemical Co., Ltd.

1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone
1267610-26-3
US $30.00 / KG
99%
Wuhan wingroup Pharmaceutical Co., Ltd

1267610-26-3(1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone)Related Search:

Apixaban Impurity BMS-591329 Apixaban Apixaban Impurity 16 Apixaban IMpurity 2 Apixaban IMpurity 3

1-(4-chlorophenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxaMide ethyl 1-(4-methoxyphenyl)-6-(4-nitrophenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate Apixaban Impurity 11 Apixaban IMpurity(BMS-591329-01) Ethyl (2Z)-chloro[(4-methoxyphenyl)hydrazono]ethanoate

1-(4-IODO-PHENYL)-PIPERIDIN-2-ONE ethyl 6-(4-aMinophenyl)-1-(4-Methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate 3-Chloro-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one Acetic acid, 2-chloro-2-[2-(4-methoxyphenyl)hydrazinylidene], ethyl ester 3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one

3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one 1-(4-Methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester 1-(4-Nitrophenyl)-2-piperidinone

1of4

1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone 2(1H)-Pyridinone, 1-(4-aMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)- Apixaba inretMediate A Apixaban Impurity S Apixaban Impurity 47 Apixaban intA Apixaban related impurities 2 Apixaban Impurity 50 ethyl 7-chloro-8-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylate，1-(4-AMinophenyl)-5,6-dihydro-3-(4- Morpholinyl)-2(1h)-pyridinone -(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone 1-(4-Aminophenyl)-5,6-dihydro-3-(4-morpholinyl)-2(1H)-pyridi... 2(1H)-Pyridinone,1-Chemicalbook(4-aMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)- 1-(4-aMinophenyl)-3-Morpholino-5,6-dihydropyridin-2(1H)-one 1-(4-aminophenyl)-5,6-dihydro-3-(4- 4-Pyrimidinol,2-methoxy-12-methyl- 1-(4-Aminophenyl)-5-Morpholin-4-yl-2,3-Dihydropyridin-6-One 5.6-Dihydro-3-(4-morpholinyl)-1-(4-aminophenyl)-2(1H)-pyridinone 1-(4-Aminophenyl)-3-(4-morpholinyl)-5,6-dihydro-2(1H)-pyridinone 1-(4-Amino Phenyl)-5,6-Dihydro-3-Morpholino-Pyridin-2(1H)-one 1-(4-aminophenyl)-5, 6-dihydro-3 -(4-morpholine)-2(1H) -pyridone 1-(4-Aminophenyl)-5,6-dihydro-3-(4-morpholinyl)-2(1H)-pyridone 1267610-26-3 267610-26-3