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MTOR inhibitor

MTOR inhibitor structure

CAS No.: 1207358-59-5

Chemical Name:: MTOR inhibitor

Synonyms: MTOR-IN-1;MTOR inhibitor;mTOR inhibitor-3;GDC-mTOR inhibitor;mTOR inhibitor (mTOR-IN-1);mTOR inhibitor-3, 10 mM in DMSO;Inhibitor,inhibit,mTOR,mTOR inhibitor 3,mTOR inhibitor-3,mTOR inhibitor3,Mammalian target of Rapamycin;N-Ethyl-N'-[4-[5,6,7,8-tetrahydro-4-[(3S)-3-methyl-4-morpholinyl]-7-(2-pyrimidinyl)pyrido[3,4-d]pyrimidin-2-yl]phenyl]urea;Urea, N-ethyl-N'-[4-[5,6,7,8-tetrahydro-4-[(3S)-3-methyl-4-morpholinyl]-7-(2-pyrimidinyl)pyrido[3,4-d]pyrimidin-2-yl]phenyl]-

CBNumber:: CB52666665

Molecular Formula:: C25H30N8O2

Molecular Weight:: 474.56

MDL Number:: MFCD25977126

MOL File:: 1207358-59-5.mol

MSDS File:: SDS

Last updated:2025-11-07 19:35:26

Product description	Number	Pack Size	Price
mTORinhibitor-3 98.54%	CS-1383	10mg	$280
GDC-mTORinhibitor	A3637	5mg	$381
mTOR-IN-1	orb611741	10mg	$547.4
mTORinhibitor-3 98.54%	CS-1383	5mg	$200
mTORinhibitor-3 98.54%	CS-1383	50mg	$750

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MTOR inhibitor Properties

Density	1.277±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO : 50 mg/mL (105.36 mM; Need ultrasonic)
form	Powder
pka	13.87±0.46(Predicted)
color	White to off-white
NCI Dictionary of Cancer Terms	mTOR inhibitor

MTOR inhibitor price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
ChemScene	CS-1383	mTORinhibitor-3 98.54%	1207358-59-5	10mg	$280	2021-12-16	Buy
ApexBio Technology	A3637	GDC-mTORinhibitor	1207358-59-5	5mg	$381	2021-12-16	Buy
Biorbyt Ltd	orb611741	mTOR-IN-1	1207358-59-5	10mg	$547.4	2021-12-16	Buy
ChemScene	CS-1383	mTORinhibitor-3 98.54%	1207358-59-5	5mg	$200	2021-12-16	Buy
ChemScene	CS-1383	mTORinhibitor-3 98.54%	1207358-59-5	50mg	$750	2021-12-16	Buy

Product number	Packaging	Price	Buy
CS-1383	10mg	$280	Buy
A3637	5mg	$381	Buy
orb611741	10mg	$547.4	Buy
CS-1383	5mg	$200	Buy
CS-1383	50mg	$750	Buy

MTOR inhibitor Chemical Properties,Uses,Production

Uses

mTOR inhibitor-3 is a remarkably selective mTOR inhibitor with a Ki of 1.5 nM. mTOR inhibitor-3 suppresses mTORC1 and mTORC2 in cellular and in vivo pharmacokinetic (PK)/pharmacodynamic (PD) experiments.

in vivo

mTOR inhibitor-3 (Compound 8h) has high free plasma clearance in both mice (1818 mL/min/kg) and rats (1538 mL/min/kg in rat) ^[1]. mTOR inhibitor-3 (Compounds 12i) is selected for this study due to its potency, selectivity, and favorable mouse PK profile. Plasma levels of mTOR inhibitor-3 6 h following oral administration in PC3 tumor-bearing mice along with the fold decreases of phosphorylated mTORC1 and -2 substrates relative to time-matched vehicle controls. mTOR inhibitor-3 has moderate terminal elimination half-life (t_1/2=1.7 h for mouse(1 mg/kg, iv)). mTOR inhibitor-3 achieves tumor stasis at the highest 200 mg/kg/day dose examined, which appears to also be approaching the limit of tolerability for this molecule^[2].

IC 50

mTOR: 1.5 nM (Ki); mTORC1; mTORC2

References

[1] Pei Z, et al. Discovery and Biological Profiling of Potent and Selective mTOR Inhibitor GDC-0349. ACS Med Chem Lett. 2012 Nov 29;4(1):103-7. DOI:10.1021/ml3003132
[2] Koehler MF, et al. Potent, selective, and orally bioavailable inhibitors of the mammalian target of rapamycin kinase domain exhibiting single agent antiproliferative activity. J Med Chem. 2012 Dec 27;55(24):10958-71. DOI:10.1021/jm301389h

MTOR inhibitor Preparation Products And Raw materials

Raw materials

Preparation Products

MTOR inhibitor Suppliers

Global( 40)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32435	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6312	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	+86-057181025280; +8617767106207	sales@molcore.com	China	49734	58
TargetMol Chemicals Inc.	+1-781-999-5354;	support@targetmol.com	United States	39035	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131957	58
Haoyuan Chemexpress Co., Ltd.	021-58950125	info@chemexpress.com	China	7552	61
MedChemexpress LLC	021-58955995	sales@medchemexpress.cn	United States	4861	58
Sichuan Wei Keqi Biological Technology Co., Ltd.	028-81700200 18116577057	3003855609@qq.com	China	7778	56
LETOPHARM LIMITED	+86-21-5821 5861	sales@letopharm.com	China	2384	58
SPIRO PHARMA		eric_feng1954@126.com	China	9248	55

Supplier	Advantage
TargetMol Chemicals Inc.	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	58
TargetMol Chemicals Inc.	58
Amadis Chemical Company Limited	58
Haoyuan Chemexpress Co., Ltd.	61
MedChemexpress LLC	58
Sichuan Wei Keqi Biological Technology Co., Ltd.	56
LETOPHARM LIMITED	58
SPIRO PHARMA	55

View Lastest Price from MTOR inhibitor manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2025-11-07	mTOR inhibitor-3 1207358-59-5	US $55.00-189.00 / mg		99.00%	10g	TargetMol Chemicals Inc.
	2025-10-26	mTOR inhibitor-3 1207358-59-5	US $55.00-189.00 / mg		99.00%	10g	TargetMol Chemicals Inc.

mTOR inhibitor-3
1207358-59-5
US $55.00-189.00 / mg
99.00%
TargetMol Chemicals Inc.

mTOR inhibitor-3
1207358-59-5
US $55.00-189.00 / mg
99.00%
TargetMol Chemicals Inc.

MTOR inhibitor Spectrum

MTOR inhibitor(1207358-59-5)¹HNMR

mTOR inhibitor (mTOR-IN-1) MTOR inhibitor MTOR-IN-1 N-Ethyl-N'-[4-[5,6,7,8-tetrahydro-4-[(3S)-3-methyl-4-morpholinyl]-7-(2-pyrimidinyl)pyrido[3,4-d]pyrimidin-2-yl]phenyl]urea GDC-mTOR inhibitor mTOR inhibitor-3 Urea, N-ethyl-N'-[4-[5,6,7,8-tetrahydro-4-[(3S)-3-methyl-4-morpholinyl]-7-(2-pyrimidinyl)pyrido[3,4-d]pyrimidin-2-yl]phenyl]- Inhibitor,inhibit,mTOR,mTOR inhibitor 3,mTOR inhibitor-3,mTOR inhibitor3,Mammalian target of Rapamycin mTOR inhibitor-3, 10 mM in DMSO 1207358-59-5 C25H30N8O2