ChemicalBook >> CAS DataBase List >>UNC0646

UNC0646

UNC0646 structure

CAS No.: 1320288-17-2

Chemical Name:: UNC0646

Synonyms: CS-792;UNC0646;UNC0646/UNC-0646;UNC 0646;UNC0646;UNC-0646;N-(1-cyclohexylpiperidin-4-yl)-2-(4-isopropyl-1,4-diazepan-1-yl)-6-Methoxy-7-(3-(piperidin-1-yl)propoxy)quinazolin-4-aMine;N-(1-Cyclohexyl-4-piperidinyl)-2-(4-isopropyl-1,4-diazepan-1-yl)- 6-methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinamine;(1-CYCLOHEXYL-PIPERIDIN-4-YL)-[2-(4-ISOPROPYL-[1,4]DIAZEPAN-1-YL)-6-METHOXY-7-(3-PIPERIDIN-1-YL-PROPOXY)-QUINAZOLIN-4-YL]-AMINE;H3K9me2,KMT1D,chromatin,EHMT1,Histone Methyltransferase,UNC-0646,SAR,inhibit,G9a,GLP,PKMT,UNC0646,Inhibitor,cell-penetration,p53;N-(1-Cyclohexyl-4-piperidinyl)-2-[hexahydro-4-(1-methylethyl)-1H-1,4-diazepin-1-yl]-6-methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinamine;4-Quinazolinamine, N-(1-cyclohexyl-4-piperidinyl)-2-[hexahydro-4-(1-methylethyl)-1H-1,4-diazepin-1-yl]-6-methoxy-7-[3-(1-piperidinyl)propoxy]-

CBNumber:: CB52667561

Molecular Formula:: C36H59N7O2

Molecular Weight:: 621.9

MDL Number:: MFCD22378486

MOL File:: 1320288-17-2.mol

Last updated:2023-06-30 15:45:59

Request For Quotation

UNC0646 Properties

Boiling point	754.6±70.0 °C(Predicted)
Density	1.128±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,2-8°C
solubility	DMSO: soluble2mg/mL, clear (warmed)
pka	9.34±0.70(Predicted)
form	powder
color	white to beige

SAFETY

Risk and Safety Statements

WGK Germany	3

UNC0646 price More Price(32)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	SML0633	UNC0646 ≥98% (HPLC)	1320288-17-2	5mg	$156	2024-03-01	Buy
Sigma-Aldrich	SML0633	UNC0646 ≥98% (HPLC)	1320288-17-2	25mg	$496	2024-03-01	Buy
Cayman Chemical	11085	UNC0646 ≥95%	1320288-17-2	1mg	$48	2024-03-01	Buy
Cayman Chemical	11085	UNC0646 ≥95%	1320288-17-2	5mg	$117	2024-03-01	Buy
Cayman Chemical	11085	UNC0646 ≥95%	1320288-17-2	10mg	$210	2024-03-01	Buy

Product number	Packaging	Price	Buy
SML0633	5mg	$156	Buy
SML0633	25mg	$496	Buy
11085	1mg	$48	Buy
11085	5mg	$117	Buy
11085	10mg	$210	Buy

UNC0646 Chemical Properties,Uses,Production

Description

G9a and G9a-like protein (GLP) are euchromatic histone-lysine methyltransferases (EHMT2 and EHMT1, respectively) that can heterodimerize with each other to methylate several proteins in addition to histone H3. UNC0646 is a potent and selective inhibitor of G9a and GLP activities in vitro (IC₅₀s = 6 and 15 nM, respectively) and G9a/GLP-mediated dimethylation of histone 3 on lysine 9 in MDA-MB-231 cells (IC₅₀ = 26 nM). It is highly selective for G9a/GLP over several other protein lysine and arginine methyltransferases. UNC0646 potently inhibits G9a/GLP activity in a variety of cancer cell lines as well as in the human fetal lung IMR-90 line. This compound selectively targets the corepressor function of G9a without affecting its ability to act as a coactivator with glucocorticoid receptor.

Uses

UNC0646 is a novel Protein lysine methyltransferase G9a inhibitor.

Definition

ChEBI: N-(1-cyclohexyl-4-piperidinyl)-6-methoxy-7-[3-(1-piperidinyl)propoxy]-2-(4-propan-2-yl-1,4-diazepan-1-yl)-4-quinazolinamine is a member of quinazolines.

storage

+4°C

References

[1] liu f, barsyte-lovejoy d, allali-hassani a, he y, herold jm, chen x, yates cm, frye sv, brown pj, huang j, vedadi m, arrowsmith ch, jin j. optimization of cellular activity of g9a inhibitors 7-aminoalkoxy-quinazolines. j med chem. 2011;54(17):6139-50.
[2] liu f, barsyte-lovejoy d, li f, xiong y, korboukh v, huang xp, allali-hassani a, janzen wp, roth bl, frye sv, arrowsmith ch, brown pj, vedadi m, jin j. discovery of an in vivo chemical probe of the lysine methyltransferases g9a and glp. j med chem. 2013;56(21):8931-42.

UNC0646 Preparation Products And Raw materials

Raw materials

Preparation Products

UNC0646 Suppliers

Global( 64)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
Career Henan Chemica Co	+86-0371-86658258 15093356674;	laboratory@coreychem.com	China	30255	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	trendseenbio@gmail.com	China	11681	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43348	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	52927	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131981	58
Shanghai Boyle Chemical Co., Ltd.		sales@boylechem.com	China	2923	55
Chembest Research Laboratories Limited	021-20908456	sales@BioChemBest.com	China	6011	61
Haoyuan Chemexpress Co., Ltd.	021-58950125	info@chemexpress.com	China	7553	61

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
Career Henan Chemica Co	58
InvivoChem	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	58
LEAPCHEM CO., LTD.	58
Aladdin Scientific	58
Amadis Chemical Company Limited	58
Shanghai Boyle Chemical Co., Ltd.	55
Chembest Research Laboratories Limited	61
Haoyuan Chemexpress Co., Ltd.	61

UNC0646 Spectrum

UNC0646(1320288-17-2)MS

1320288-17-2(UNC0646)Related Search:

UNC0321 (trifluoroacetate salt) UNC2541 UNC 1079 UNC 0224 1-Methyl-4-piperidone

N-Methylpiperidine 3-Hydroxy-1-methylpiperidine UNC3866 UNC0379 UNC 669

UNC2250 UNC-1215 UNC-926 Hydochloride UNC569 NUC-7738

UNC2025 UNC0638 UNC-0642

1of4

UNC0646 N-(1-cyclohexylpiperidin-4-yl)-2-(4-isopropyl-1,4-diazepan-1-yl)-6-Methoxy-7-(3-(piperidin-1-yl)propoxy)quinazolin-4-aMine UNC0646/UNC-0646 N-(1-Cyclohexyl-4-piperidinyl)-2-[hexahydro-4-(1-methylethyl)-1H-1,4-diazepin-1-yl]-6-methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinamine N-(1-Cyclohexyl-4-piperidinyl)-2-(4-isopropyl-1,4-diazepan-1-yl)- 6-methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinamine (1-CYCLOHEXYL-PIPERIDIN-4-YL)-[2-(4-ISOPROPYL-[1,4]DIAZEPAN-1-YL)-6-METHOXY-7-(3-PIPERIDIN-1-YL-PROPOXY)-QUINAZOLIN-4-YL]-AMINE UNC 0646;UNC0646;UNC-0646 CS-792 4-Quinazolinamine, N-(1-cyclohexyl-4-piperidinyl)-2-[hexahydro-4-(1-methylethyl)-1H-1,4-diazepin-1-yl]-6-methoxy-7-[3-(1-piperidinyl)propoxy]- H3K9me2,KMT1D,chromatin,EHMT1,Histone Methyltransferase,UNC-0646,SAR,inhibit,G9a,GLP,PKMT,UNC0646,Inhibitor,cell-penetration,p53 1320288-17-2 C36H59N7O2