2-Acetylfuro-1,4-naphthoquinone
- CAS No.
- 83280-65-3
- Chemical Name:
- 2-Acetylfuro-1,4-naphthoquinone
- Synonyms
- 139057;CS-945;BBI-606;Napabucasin;Napabucasin Impurity;Remimazolam besylate;Napabucasin (BBI608);2-Acetylfuro-1,4-phthoquinone;2-Acetylfuro-1,4-naphthoquinone;2-acetylnaphtho[2,3-b]furan-4,9-quinone
- CBNumber:
- CB52667637
- Molecular Formula:
- C14H8O4
- Molecular Weight:
- 240.21
- MDL Number:
- MFCD28155270
- MOL File:
- 83280-65-3.mol
- MSDS File:
- SDS
| Melting point | 225-226℃ (dichloromethane ) |
|---|---|
| Boiling point | 444.4±45.0 °C(Predicted) |
| Density | 1.385±0.06 g/cm3(Predicted) |
| storage temp. | +2C to +8C |
| solubility | Soluble in DMSO (up to 20 mg/ml) |
| form | Brown solid |
| color | Yellow |
| λmax | 272nm(EtOH)(lit.) |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| FDA UNII | Z1HHM49K7O |
| NCI Drug Dictionary | napabucasin |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| HS Code | 2932.99.7000 |
2-Acetylfuro-1,4-naphthoquinone price More Price(38)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 5.33851 | Cancer Stemness Inhibitor, BBI608 - CAS 83280-65-3 - Calbiochem | 83280-65-3 | 10mg | $129 | 2024-03-01 | Buy |
| TCI Chemical | A3110 | 2-Acetylnaphtho[2,3-b]furan-4,9-dione >98.0%(GC) | 83280-65-3 | 25mg | $165 | 2024-03-01 | Buy |
| TCI Chemical | A3110 | 2-Acetylnaphtho[2,3-b]furan-4,9-dione >98.0%(GC) | 83280-65-3 | 100mg | $457 | 2024-03-01 | Buy |
| Cayman Chemical | 22255 | Napabucasin ≥98% | 83280-65-3 | 5mg | $68 | 2024-03-01 | Buy |
| Cayman Chemical | 22255 | Napabucasin ≥98% | 83280-65-3 | 10mg | $116 | 2024-03-01 | Buy |
2-Acetylfuro-1,4-naphthoquinone Chemical Properties,Uses,Production
Description
Napabucasin is an inhibitor of cancer cell stemness. It reduces growth in a panel of cancer cells enriched for high stemness (IC50s = 0.291-1.249 μM) and decreases protein and gene expression of various self-renewal and pro-survival markers including Nanog, Smo, Axl, Atm, and Bmi-1 in a concentration-dependent manner in FaDu head and neck squamous cell carcinoma (HNSCC) cells. In vivo, napabucasin (20 mg/kg per day) inhibits tumor growth in a PaCa-2 mouse xenograft model and prevents tumor regrowth after cessation of treatment. It blocks formation of spleen and liver metastases in an HT29 intrasplenic nude mouse model system (ISMS) model. Napabucasin (40 mg/kg, i.p.) also reduces tumor volume in PC3 and 22RV1 prostate cancer mouse xenograft models.
Uses
Napabucasin is a cancer cell stemness inhibitor which attenuates the progression of prostate cancer.
storage
Store at -20°C
References
1) Li et al. (2015), Suppression of cancer relapse and metastasis by inhibiting cancer stemness; Proc. Natl. Acad. Sci. USA, 112 1839 2) Hubbard and Grothey (2017), Napabucasin: an Update on the First-in-Class Cancer Stemness Inhibitor; Drugs, 77 1091 3) Zhang et al. (2016), Suppression of prostate cancer progression by cancer cell stemness inhibitor napabucasin; Cancer Med., 5 1251 4) MacDonagh et al. (2018), BBI608 inhibits cancer stemness and reverses cisplatin resistance in NSCLC; Cancer Lett., 428 117
2-Acetylfuro-1,4-naphthoquinone Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3012 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| TianYuan Pharmaceutical CO.,LTD | +86-755-23284190 13684996853 | sales@tianpharm.com | CHINA | 304 | 58 |
| Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 967 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| Shanxi Xuanran Import and Export Trade Co., Ltd. | +8617735180244 | mike_yan@xuanranglobal.com | CHINA | 4022 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
View Lastest Price from 2-Acetylfuro-1,4-naphthoquinone manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-17 | Napabucasin
83280-65-3
|
US $1.20 / g | 1g | 99.0% min | 10 tons min | Shaanxi Dideu Medichem Co. Ltd | |
 |
2024-03-28 | Napabucasin(BBI-608)
83280-65-3
|
US $0.00 / kg | 25kg | 98%-99% | Inquiry | PNP Biotech Co. Ltd | |
 |
2023-07-31 | Napabucasin
83280-65-3
|
US $500.00 / kg | 20kg | 99% | 500tons | Hebei Linwo New Material Technology Co., LTD |
-
- Napabucasin
83280-65-3
- US $1.20 / g
- 99.0% min
- Shaanxi Dideu Medichem Co. Ltd
-
- Napabucasin(BBI-608)
83280-65-3
- US $0.00 / kg
- 98%-99%
- PNP Biotech Co. Ltd
-
- Napabucasin
83280-65-3
- US $500.00 / kg
- 99%
- Hebei Linwo New Material Technology Co., LTD