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ChemicalBook >> CAS DataBase List >>(2R,3S)-2-[(1S)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophenyl)Morpholine hydrochloride

(2R,3S)-2-[(1S)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophenyl)Morpholine hydrochloride

(2R,3S)-2-[(1S)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophenyl)Morpholine hydrochloride Structure
(2R,3S)-2-[(1S)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophenyl)Morpholine hydrochloride structure
CAS No.
1185503-48-3
Chemical Name:
(2R,3S)-2-[(1S)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophenyl)Morpholine hydrochloride
Synonyms
Aprepitant intermediate 1;Fosaprepitant Impurity 31;Aprepitant Impurity 12 HCl;Aprepitant intermediate 1 HCl;Arepitam intermediate 1 hydrochloride;Des-1,2,4-triazol-3-one-5-methyl (2S,3R,1'R)-Aprepitant;(2R,3S)-2-[(1S)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophe;Morpholine, 2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-, (2S,3R)-;(2R,3S)-2-[(1S)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophenyl)Morpholine hydrochloride
CBNumber:
CB52669000
Molecular Formula:
C20H18F7NO2
Molecular Weight:
437.35
MDL Number:
MOL File:
1185503-48-3.mol
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(2R,3S)-2-[(1S)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophenyl)Morpholine hydrochloride Properties

Boiling point 387.9±42.0 °C(Predicted)
Density 1.37±0.1 g/cm3(Predicted)
pka 6.93±0.60(Predicted)

(2R,3S)-2-[(1S)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophenyl)Morpholine hydrochloride price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC D297835 Des-1,2,4-triazol-3-one-5-methyl(2S,3R,1''R)-Aprepitant 1185503-48-3 1mg $90 2021-12-16 Buy
TRC D297835 Des-1,2,4-triazol-3-one-5-methyl(2S,3R,1''R)-Aprepitant 1185503-48-3 5mg $235 2021-12-16 Buy
Product number Packaging Price Buy
D297835 1mg $90 Buy
D297835 5mg $235 Buy

(2R,3S)-2-[(1S)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophenyl)Morpholine hydrochloride Chemical Properties,Uses,Production

Uses

Des-1,2,4-triazol-3-one-5-methyl (2S,3R,1''R)-Aprepitant is an impurity of Aprepitant (A729800); a novel selective neurokinin-1 (NK-1) receptor antagonist. In vitro studies using human liver microsomes indicate that Aprepitant is metabolised primarily by CYP3A4 with minor metabolism by CYP1A2 and CYP2C19, and no metabolism by CYP2D6, CYP2C9, or CYP2E1. Antiemetic.

(2R,3S)-2-[(1S)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophenyl)Morpholine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

(2R,3S)-2-[(1S)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophenyl)Morpholine hydrochloride Suppliers

Global( 36)Suppliers
Supplier Tel Email Country ProdList Advantage
ANHUI WITOP BIOTECH CO., LTD 		+8615255079626 eric@witopchemical.com China 23556 58
Wuhan Topule Biopharmaceutical Co., Ltd 		+8618327326525 masar@topule.com China 8474 58
S.Z. PhyStandard Bio-Tech. Co., Ltd. 0755-4000505016 13380397412 3001272453@qq.com China 4979 50
Shanghai Ranxon Chemical Co., Ltd. 13148101715 2073632910@qq.com China 38 55
Nanjing XiZe Biotechnology CO., Ltd. 025-58362220 15250997978 1511893459@qq.com China 7715 55
ShangHai Biochempartner Co.,Ltd 17754423994 17754423994 2853530910@QQ.com China 8011 62
Shenzhen SUNGENING Bio-Medical Co., Ltd. 0755-28967200 13631290199 wxf@sungening.com China 9506 60
Shanghai Fuyi Biological Technology Co., Ltd. 18096642264 sales@foreversyn.com China 492 58
BOC Sciences -- info@bocsci.com USA 0 65
Guangzhou Dreampharm Biotechnology Co., Ltd. 17825480238 3008233717@qq.com China 9844 12
Supplier Advantage
ANHUI WITOP BIOTECH CO., LTD 		58
Wuhan Topule Biopharmaceutical Co., Ltd 		58
S.Z. PhyStandard Bio-Tech. Co., Ltd. 50
Shanghai Ranxon Chemical Co., Ltd. 55
Nanjing XiZe Biotechnology CO., Ltd. 55
ShangHai Biochempartner Co.,Ltd 62
Shenzhen SUNGENING Bio-Medical Co., Ltd. 60
Shanghai Fuyi Biological Technology Co., Ltd. 58
BOC Sciences 65
Guangzhou Dreampharm Biotechnology Co., Ltd. 12

1185503-48-3((2R,3S)-2-[(1S)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophenyl)Morpholine hydrochloride)Related Search:

Aprepitant Impurity 17 (2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(phenyl)Morpholine hydrochloride (2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(phenyl)Morpholine Aprepitant Aprepitant
Fosaprepitant Impurity 6 [2R-[2aR*),3a]-2-[1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine (R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol 4-BENZYL-2-HYDROXY-MORPHOLIN-3-ONE Aprepitant
Fosaprepitant Impurity 5 5-(hydroxymethyl)-1,2-dihydro-1,2,4-triazol-3-one (S)-2-((R)-1-(3,5-bis(trifluoroMethyl)phenyl)ethoxy)-4-benzylMorpholin-3-one 1,1,1-Trimethoxy-2-chloroethane Aprepitant
(2S,3R)-2-((S)-1-(3,5-bis(trifluoroMethyl)phenyl)ethoxy)-3-(4-fluorophenyl)Morpholine Benzyl dihydrogen phosphate (2R,3R)-2-[(1R)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophenyl)Morpholine

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(2R,3S)-2-[(1S)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophenyl)Morpholine hydrochloride Des-1,2,4-triazol-3-one-5-methyl (2S,3R,1'R)-Aprepitant Morpholine, 2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-, (2S,3R)- Aprepitant intermediate 1 HCl Aprepitant intermediate 1 Arepitam intermediate 1 hydrochloride Fosaprepitant Impurity 31 Aprepitant Impurity 12 HCl (2R,3S)-2-[(1S)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophe 1185503-48-3