KHELLIN
- CAS No.
- 82-02-0
- Chemical Name:
- KHELLIN
- Synonyms
- VISNAGIN;eskel;norkel;KHELIN;keloid;ammivin;KHELLIN;chellin;kelamin;kelicor
- CBNumber:
- CB5269554
- Molecular Formula:
- C14H12O5
- Molecular Weight:
- 260.24
- MDL Number:
- MFCD00005007
- MOL File:
- 82-02-0.mol
Melting point | 150154°C |
---|---|
Boiling point | 180200°C0.05mm Hg |
Density | 1.1954 (rough estimate) |
refractive index | 1.4560 (estimate) |
storage temp. | Sealed in dry,Room Temperature |
solubility | Chloroform (Slightly), Methanol (Slightly) |
form | crystalline |
color | light yellow |
Water Solubility | 247.2g/L(25 ºC) |
Merck | 14,5309 |
BRN | 263185 |
LogP | 1.770 (est) |
NCI Dictionary of Cancer Terms | keloid |
FDA UNII | 5G117T0TJZ |
EPA Substance Registry System | Khellin (82-02-0) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS06 |
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Signal word | Danger | |||||||||
Hazard statements | H301+H311+H331-H315-H319-H335 | |||||||||
Precautionary statements | P280-P301+P310+P330-P302+P352+P312-P304+P340+P311-P305+P351+P338 | |||||||||
Hazard Codes | T | |||||||||
Risk Statements | 25-38-36/37/38-23/24/25 | |||||||||
Safety Statements | 36/37/39-45-26 | |||||||||
RIDADR | UN 2811 6.1/PG 3 | |||||||||
WGK Germany | 3 | |||||||||
RTECS | LV1050000 | |||||||||
HS Code | 2932.99.7000 | |||||||||
HazardClass | 6.1(b) | |||||||||
PackingGroup | III | |||||||||
Toxicity | LD50 in mice, rats (mg/kg): 30.6, 34.4 i.v.; 50.8, 68.8 orally (Busch) | |||||||||
NFPA 704 |
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KHELLIN price More Price(22)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | PHL89481 | Khellin phyproof? Reference Substance | 82-02-0 | 100MG | $358 | 2024-03-01 | Buy |
Sigma-Aldrich | 60730 | Khellin for microscopy | 82-02-0 | 10g | $234 | 2024-03-01 | Buy |
Sigma-Aldrich | 00899 | Khellin analytical standard | 82-02-0 | 100MG | $244 | 2024-03-01 | Buy |
TCI Chemical | K0039 | Khellin >95.0%(GC) | 82-02-0 | 5g | $155 | 2024-03-01 | Buy |
TCI Chemical | K0039 | Khellin >95.0%(GC) | 82-02-0 | 25g | $497 | 2024-03-01 | Buy |
KHELLIN Chemical Properties,Uses,Production
Uses
vasodilator (coronary), photosensitizer
Uses
Khellin has been used as a reference standard for supercritical fluid extraction of khellin from Ammi visnaga L. fruits to understand the various medicinal effects of γ-Pyrones by reversed phase HPLC method.
Definition
ChEBI: Khellin is a furanochrome in which the basic tricyclic skeleton is substituted at positions 4 and 9 with methoxy groups and at position 7 with a methyl group. A major constituent of the plant Ammi visnaga it is a herbal folk medicine used for various illnesses, its main effect being as a vasodilator. It has a role as a vasodilator agent, a bronchodilator agent, an anti-asthmatic agent and a cardiovascular drug. It is an organic heterotricyclic compound, an oxacycle and a furanochromone. It is functionally related to a 5H-furo[3,2-g]chromen-5-one.
brand name
Ammivin (Marion Merrell Dow); Khelloyd (Hoechst-Roussel).
Synthesis Reference(s)
Journal of Medicinal Chemistry, 26, p. 1672, 1983 DOI: 10.1021/jm00366a002
General Description
Khellin, is reported to be an efficient drug for treating vitiligo when combined with ultraviolet A irradiation.
Purification Methods
Crystallise khellin from H2O, MeOH, pet ether or Et2O. The hydrochloride has m 98o(dec) (from EtOH/HCl). [Beilstein 19 II 236, 19 III/IV 2816, 19/6 V 320.]
KHELLIN Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21667 | 55 |
Xi'an Kono chem co., Ltd., | 029-86107037 13289246953 | info@konochemical.com | China | 2995 | 58 |
Antai Fine Chemical Technology Co.,Limited | 18503026267 | info@antaichem.com | CHINA | 9641 | 58 |
Wuhan ChemNorm Biotech Co.,Ltd. | +86-27-8439 4403 18971486879 | sales@chemnorm.com | CHINA | 2935 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
Hubei Ipure Biology Co., Ltd | +8613367258412 | ada@ipurechemical.com | China | 10326 | 58 |
Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 8132 | 58 |
ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | product@acmec-e.com | China | 33350 | 58 |
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